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A single locus regulates a female-limited color pattern polymorphism in a reptile

Feiner, Nathalie LU ; Brun-Usan, Miguel LU ; Andrade, Pedro ; Pranter, Robin LU orcid ; Park, Sungdae ; Menke, Douglas B. ; Geneva, Anthony J. and Uller, Tobias LU (2022) In Science Advances 8(10).
Abstract

Animal coloration is often expressed in periodic patterns that can arise from differential cell migration, yet how these processes are regulated remains elusive. We show that a female-limited polymorphism in dorsal patterning (diamond/chevron) in the brown anole is controlled by a single Mendelian locus. This locus contains the gene CCDC170 that is adjacent to, and coexpressed with, the Estrogen receptor-1 gene, explaining why the polymorphism is female limited. CCDC170 is an organizer of the Golgi-microtubule network underlying a cell's ability to migrate, and the two segregating alleles encode structurally different proteins. Our agent-based modeling of skin development demonstrates that, in principle, a change in cell migratory... (More)

Animal coloration is often expressed in periodic patterns that can arise from differential cell migration, yet how these processes are regulated remains elusive. We show that a female-limited polymorphism in dorsal patterning (diamond/chevron) in the brown anole is controlled by a single Mendelian locus. This locus contains the gene CCDC170 that is adjacent to, and coexpressed with, the Estrogen receptor-1 gene, explaining why the polymorphism is female limited. CCDC170 is an organizer of the Golgi-microtubule network underlying a cell's ability to migrate, and the two segregating alleles encode structurally different proteins. Our agent-based modeling of skin development demonstrates that, in principle, a change in cell migratory behaviors is sufficient to switch between the two morphs. These results suggest that CCDC170 might have been co-opted as a switch between color patterning morphs, likely by modulating cell migratory behaviors.

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author
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Science Advances
volume
8
issue
10
article number
eabm2387
publisher
American Association for the Advancement of Science (AAAS)
external identifiers
  • pmid:35263124
  • scopus:85126076124
ISSN
2375-2548
DOI
10.1126/sciadv.abm2387
language
English
LU publication?
yes
id
9b410e95-ee84-4e65-ae8d-c4521e50ac42
date added to LUP
2022-04-20 12:31:55
date last changed
2025-01-14 06:22:15
@article{9b410e95-ee84-4e65-ae8d-c4521e50ac42,
  abstract     = {{<p>Animal coloration is often expressed in periodic patterns that can arise from differential cell migration, yet how these processes are regulated remains elusive. We show that a female-limited polymorphism in dorsal patterning (diamond/chevron) in the brown anole is controlled by a single Mendelian locus. This locus contains the gene CCDC170 that is adjacent to, and coexpressed with, the Estrogen receptor-1 gene, explaining why the polymorphism is female limited. CCDC170 is an organizer of the Golgi-microtubule network underlying a cell's ability to migrate, and the two segregating alleles encode structurally different proteins. Our agent-based modeling of skin development demonstrates that, in principle, a change in cell migratory behaviors is sufficient to switch between the two morphs. These results suggest that CCDC170 might have been co-opted as a switch between color patterning morphs, likely by modulating cell migratory behaviors.</p>}},
  author       = {{Feiner, Nathalie and Brun-Usan, Miguel and Andrade, Pedro and Pranter, Robin and Park, Sungdae and Menke, Douglas B. and Geneva, Anthony J. and Uller, Tobias}},
  issn         = {{2375-2548}},
  language     = {{eng}},
  number       = {{10}},
  publisher    = {{American Association for the Advancement of Science (AAAS)}},
  series       = {{Science Advances}},
  title        = {{A single locus regulates a female-limited color pattern polymorphism in a reptile}},
  url          = {{http://dx.doi.org/10.1126/sciadv.abm2387}},
  doi          = {{10.1126/sciadv.abm2387}},
  volume       = {{8}},
  year         = {{2022}},
}