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Pathophysiology of meningioma growth in pregnancy

Hortobágyi, Tibor; Bencze, János; Murnyák, Balázs; Kouhsari, Mahan C.; Bognár, László and Marko-Varga, György LU (2017) In Open Medicine (Poland) 12(1). p.195-200
Abstract

Meningioma is among the most frequent brain tumours predominantly affecting elderly women. Epidemiological studies have shown that at the age of fertility the incidence is relatively low. The biological behaviour of meningioma in pregnancy is different from other meningiomas. The possible explanation is rooted in the complex physiological changes and hormonal differences during pregnancy. The increased meningioma growth observed in pregnancy is presumably the result of endocrine mechanisms. These include increase in progesterone, human placental lactogen (hPL) and prolactin (PRL) serum levels. In contrast, levels of pituitary hormones such as follicle stimulating hormone (FSH), luteinizing hormone (LH) and human chorionic gonadotropin... (More)

Meningioma is among the most frequent brain tumours predominantly affecting elderly women. Epidemiological studies have shown that at the age of fertility the incidence is relatively low. The biological behaviour of meningioma in pregnancy is different from other meningiomas. The possible explanation is rooted in the complex physiological changes and hormonal differences during pregnancy. The increased meningioma growth observed in pregnancy is presumably the result of endocrine mechanisms. These include increase in progesterone, human placental lactogen (hPL) and prolactin (PRL) serum levels. In contrast, levels of pituitary hormones such as follicle stimulating hormone (FSH), luteinizing hormone (LH) and human chorionic gonadotropin (hCG) produced by the placenta are decreasing in the mother prior to childbirth. Besides, vascular factors also play a crucial role. Peritumoral brain edema (PTBE), with well-known causative association with vascular endothelial growth factor (VEGF), can often be seen both with imaging and in the surgical specimens. Our aim is to assess published research on this topic including diagnostic and therapeutic guidelines, and to provide a clinically useful overview on the pathophysiology and biological behaviour of this rare complication of pregnancy.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Endocrinology, Hemodynamics, Meningioma, Pathophysiology, Pregnancy
in
Open Medicine (Poland)
volume
12
issue
1
pages
6 pages
publisher
Walter De Gruyter
external identifiers
  • scopus:85024870376
  • wos:000407813800001
DOI
10.1515/med-2017-0029
language
English
LU publication?
yes
id
9b67e592-ac2c-4fb5-ae69-5492cd89ce00
date added to LUP
2017-08-31 13:56:45
date last changed
2018-01-07 12:16:53
@article{9b67e592-ac2c-4fb5-ae69-5492cd89ce00,
  abstract     = {<p>Meningioma is among the most frequent brain tumours predominantly affecting elderly women. Epidemiological studies have shown that at the age of fertility the incidence is relatively low. The biological behaviour of meningioma in pregnancy is different from other meningiomas. The possible explanation is rooted in the complex physiological changes and hormonal differences during pregnancy. The increased meningioma growth observed in pregnancy is presumably the result of endocrine mechanisms. These include increase in progesterone, human placental lactogen (hPL) and prolactin (PRL) serum levels. In contrast, levels of pituitary hormones such as follicle stimulating hormone (FSH), luteinizing hormone (LH) and human chorionic gonadotropin (hCG) produced by the placenta are decreasing in the mother prior to childbirth. Besides, vascular factors also play a crucial role. Peritumoral brain edema (PTBE), with well-known causative association with vascular endothelial growth factor (VEGF), can often be seen both with imaging and in the surgical specimens. Our aim is to assess published research on this topic including diagnostic and therapeutic guidelines, and to provide a clinically useful overview on the pathophysiology and biological behaviour of this rare complication of pregnancy.</p>},
  author       = {Hortobágyi, Tibor and Bencze, János and Murnyák, Balázs and Kouhsari, Mahan C. and Bognár, László and Marko-Varga, György},
  keyword      = {Endocrinology,Hemodynamics,Meningioma,Pathophysiology,Pregnancy},
  language     = {eng},
  month        = {01},
  number       = {1},
  pages        = {195--200},
  publisher    = {Walter De Gruyter},
  series       = {Open Medicine (Poland)},
  title        = {Pathophysiology of meningioma growth in pregnancy},
  url          = {http://dx.doi.org/10.1515/med-2017-0029},
  volume       = {12},
  year         = {2017},
}