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Metastatic Voyage of Ovarian Cancer Cells in Ascites with the Assistance of Various Cellular Components

Uno, Kaname LU orcid ; Iyoshi, Shohei ; Yoshihara, Masato ; Kitami, Kazuhisa ; Mogi, Kazumasa ; Fujimoto, Hiroki ; Sugiyama, Mai ; Koya, Yoshihiro ; Yamakita, Yoshihiko and Nawa, Akihiro , et al. (2022) In International Journal of Molecular Sciences 23(8). p.1-17
Abstract

Epithelial ovarian cancer (EOC) is the most lethal gynecologic malignancy and has a unique metastatic route using ascites, known as the transcoelomic root. However, studies on ascites and contained cellular components have not yet been sufficiently clarified. In this review, we focus on the significance of accumulating ascites, contained EOC cells in the form of spheroids, and interaction with non-malignant host cells. To become resistant against anoikis, EOC cells form spheroids in ascites, where epithelial-to-mesenchymal transition stimulated by transforming growth factor-β can be a key pathway. As spheroids form, EOC cells are also gaining the ability to attach and invade the peritoneum to induce intraperitoneal metastasis, as well... (More)

Epithelial ovarian cancer (EOC) is the most lethal gynecologic malignancy and has a unique metastatic route using ascites, known as the transcoelomic root. However, studies on ascites and contained cellular components have not yet been sufficiently clarified. In this review, we focus on the significance of accumulating ascites, contained EOC cells in the form of spheroids, and interaction with non-malignant host cells. To become resistant against anoikis, EOC cells form spheroids in ascites, where epithelial-to-mesenchymal transition stimulated by transforming growth factor-β can be a key pathway. As spheroids form, EOC cells are also gaining the ability to attach and invade the peritoneum to induce intraperitoneal metastasis, as well as resistance to conventional chemotherapy. Recently, accumulating evidence suggests that EOC spheroids in ascites are composed of not only cancer cells, but also non-malignant cells existing with higher abundance than EOC cells in ascites, including macrophages, mesothelial cells, and lymphocytes. Moreover, hetero-cellular spheroids are demonstrated to form more aggregated spheroids and have higher adhesion ability for the mesothelial layer. To improve the poor prognosis, we need to elucidate the mechanisms of spheroid formation and interactions with non-malignant cells in ascites that are a unique tumor microenvironment for EOC.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Ascites/pathology, Carcinoma, Ovarian Epithelial, Cell Line, Tumor, Female, Humans, Neoplasms, Glandular and Epithelial, Ovarian Neoplasms/pathology, Spheroids, Cellular/metabolism, Tumor Microenvironment
in
International Journal of Molecular Sciences
volume
23
issue
8
article number
4383
pages
1 - 17
publisher
MDPI AG
external identifiers
  • pmid:35457198
  • scopus:85128216849
ISSN
1422-0067
DOI
10.3390/ijms23084383
language
English
LU publication?
yes
id
9b7ab9f1-0c7c-4a8a-b673-28098d930b81
date added to LUP
2022-06-13 16:29:39
date last changed
2024-06-13 17:54:52
@article{9b7ab9f1-0c7c-4a8a-b673-28098d930b81,
  abstract     = {{<p>Epithelial ovarian cancer (EOC) is the most lethal gynecologic malignancy and has a unique metastatic route using ascites, known as the transcoelomic root. However, studies on ascites and contained cellular components have not yet been sufficiently clarified. In this review, we focus on the significance of accumulating ascites, contained EOC cells in the form of spheroids, and interaction with non-malignant host cells. To become resistant against anoikis, EOC cells form spheroids in ascites, where epithelial-to-mesenchymal transition stimulated by transforming growth factor-β can be a key pathway. As spheroids form, EOC cells are also gaining the ability to attach and invade the peritoneum to induce intraperitoneal metastasis, as well as resistance to conventional chemotherapy. Recently, accumulating evidence suggests that EOC spheroids in ascites are composed of not only cancer cells, but also non-malignant cells existing with higher abundance than EOC cells in ascites, including macrophages, mesothelial cells, and lymphocytes. Moreover, hetero-cellular spheroids are demonstrated to form more aggregated spheroids and have higher adhesion ability for the mesothelial layer. To improve the poor prognosis, we need to elucidate the mechanisms of spheroid formation and interactions with non-malignant cells in ascites that are a unique tumor microenvironment for EOC.</p>}},
  author       = {{Uno, Kaname and Iyoshi, Shohei and Yoshihara, Masato and Kitami, Kazuhisa and Mogi, Kazumasa and Fujimoto, Hiroki and Sugiyama, Mai and Koya, Yoshihiro and Yamakita, Yoshihiko and Nawa, Akihiro and Kanayama, Tomohiro and Tomita, Hiroyuki and Enomoto, Atsushi and Kajiyama, Hiroaki}},
  issn         = {{1422-0067}},
  keywords     = {{Ascites/pathology; Carcinoma, Ovarian Epithelial; Cell Line, Tumor; Female; Humans; Neoplasms, Glandular and Epithelial; Ovarian Neoplasms/pathology; Spheroids, Cellular/metabolism; Tumor Microenvironment}},
  language     = {{eng}},
  number       = {{8}},
  pages        = {{1--17}},
  publisher    = {{MDPI AG}},
  series       = {{International Journal of Molecular Sciences}},
  title        = {{Metastatic Voyage of Ovarian Cancer Cells in Ascites with the Assistance of Various Cellular Components}},
  url          = {{http://dx.doi.org/10.3390/ijms23084383}},
  doi          = {{10.3390/ijms23084383}},
  volume       = {{23}},
  year         = {{2022}},
}