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Intracranial bleeding due to vitamin K deficiency : Advantages of using a pediatric intensive care registry

Visser, Désirée Y. ; Jansen, Nicolaas J. ; Ijland, Marloes M. ; De Koning, Tom J. LU and Van Hasselt, Peter M. (2011) In Intensive Care Medicine 37(6). p.1014-1020
Abstract

Aim: To determine the incidence of late intracranial vitamin K deficiency bleeding (VKDB) in The Netherlands using the Dutch Pediatric Intensive Care Evaluation (PICE) registry. Methods: The PICE registry was used to identify all infants who were admitted to a Dutch pediatric intensive care unit (PICU) with intracranial bleeding between 1 January 2004 and 31 December 2007. Cases of confirmed late intracranial VKDB were used to calculate the incidence for each year. To estimate the completeness of ascertainment of the PICE registry, data from 2005 were compared with general surveillance data from that year. Results: In the 4-year study period, 16/64 (25%) of the infants admitted with intracranial bleeding had late intracranial VKDB,... (More)

Aim: To determine the incidence of late intracranial vitamin K deficiency bleeding (VKDB) in The Netherlands using the Dutch Pediatric Intensive Care Evaluation (PICE) registry. Methods: The PICE registry was used to identify all infants who were admitted to a Dutch pediatric intensive care unit (PICU) with intracranial bleeding between 1 January 2004 and 31 December 2007. Cases of confirmed late intracranial VKDB were used to calculate the incidence for each year. To estimate the completeness of ascertainment of the PICE registry, data from 2005 were compared with general surveillance data from that year. Results: In the 4-year study period, 16/64 (25%) of the infants admitted with intracranial bleeding had late intracranial VKDB, resulting in an overall incidence of 2.1/100,000 live births (95% confidence interval 1.2-3.5). The single-year incidence varied markedly between 0.5 and 3.3 per 100,000 live births. All five ascertained cases in 2005 were identified using the PICE registry, while general surveillance identified only three. Conclusions: The PICE registry allows ongoing monitoring of the incidence of late intracranial VKDB and appears to be associated with a higher rate of completeness than general surveillance. We propose the use of pediatric intensive care registries to assess the efficacy of national vitamin K prophylactic regimens.

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author
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publishing date
type
Contribution to journal
publication status
published
subject
keywords
General surveillance, Intracranial bleeding, Pediatric Intensive Care Evaluation registry, Prophylaxis, Vitamin K deficiency
in
Intensive Care Medicine
volume
37
issue
6
pages
7 pages
publisher
Springer
external identifiers
  • scopus:79959709831
  • pmid:21394627
ISSN
0342-4642
DOI
10.1007/s00134-011-2175-7
language
English
LU publication?
no
id
9b932330-33b4-4601-82f1-7d03ebea592c
date added to LUP
2020-02-26 10:20:07
date last changed
2024-05-01 07:03:14
@article{9b932330-33b4-4601-82f1-7d03ebea592c,
  abstract     = {{<p>Aim: To determine the incidence of late intracranial vitamin K deficiency bleeding (VKDB) in The Netherlands using the Dutch Pediatric Intensive Care Evaluation (PICE) registry. Methods: The PICE registry was used to identify all infants who were admitted to a Dutch pediatric intensive care unit (PICU) with intracranial bleeding between 1 January 2004 and 31 December 2007. Cases of confirmed late intracranial VKDB were used to calculate the incidence for each year. To estimate the completeness of ascertainment of the PICE registry, data from 2005 were compared with general surveillance data from that year. Results: In the 4-year study period, 16/64 (25%) of the infants admitted with intracranial bleeding had late intracranial VKDB, resulting in an overall incidence of 2.1/100,000 live births (95% confidence interval 1.2-3.5). The single-year incidence varied markedly between 0.5 and 3.3 per 100,000 live births. All five ascertained cases in 2005 were identified using the PICE registry, while general surveillance identified only three. Conclusions: The PICE registry allows ongoing monitoring of the incidence of late intracranial VKDB and appears to be associated with a higher rate of completeness than general surveillance. We propose the use of pediatric intensive care registries to assess the efficacy of national vitamin K prophylactic regimens.</p>}},
  author       = {{Visser, Désirée Y. and Jansen, Nicolaas J. and Ijland, Marloes M. and De Koning, Tom J. and Van Hasselt, Peter M.}},
  issn         = {{0342-4642}},
  keywords     = {{General surveillance; Intracranial bleeding; Pediatric Intensive Care Evaluation registry; Prophylaxis; Vitamin K deficiency}},
  language     = {{eng}},
  month        = {{06}},
  number       = {{6}},
  pages        = {{1014--1020}},
  publisher    = {{Springer}},
  series       = {{Intensive Care Medicine}},
  title        = {{Intracranial bleeding due to vitamin K deficiency : Advantages of using a pediatric intensive care registry}},
  url          = {{http://dx.doi.org/10.1007/s00134-011-2175-7}},
  doi          = {{10.1007/s00134-011-2175-7}},
  volume       = {{37}},
  year         = {{2011}},
}