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Cerebral Glucose Transport and Homeostasis

Duarte, Joao LU orcid and Gruetter, Rolf (2012) In Advances in Neurobiology 4. p.655-673
Abstract
Cerebral glucose homeostasis is maintained by the equilibrium between glucose transport across the blood-brain-barrier (BBB), which occurs through facilitative carriers, and glucose consumption mainly initiated by hexokinase phosphorylation. Glucose concentrations can be quantified non invasively by nuclear magnetic resonance (NMR) spectroscopy and such measurements, through appropriate mathematical modelling, allow to determine the kinetics of glucose transport and metabolism. This chapter summarizes the insights gained into brain glucose transport from the measurement of the brain glucose concentration, particularly reviewing state of the art NMR methods for non invasive determination of glucose homeostasis and discussing the employment... (More)
Cerebral glucose homeostasis is maintained by the equilibrium between glucose transport across the blood-brain-barrier (BBB), which occurs through facilitative carriers, and glucose consumption mainly initiated by hexokinase phosphorylation. Glucose concentrations can be quantified non invasively by nuclear magnetic resonance (NMR) spectroscopy and such measurements, through appropriate mathematical modelling, allow to determine the kinetics of glucose transport and metabolism. This chapter summarizes the insights gained into brain glucose transport from the measurement of the brain glucose concentration, particularly reviewing state of the art NMR methods for non invasive determination of glucose homeostasis and discussing the employment of mathematical models of glucose transport. (Less)
Please use this url to cite or link to this publication:
author
and
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
host publication
Neural Metabolism In Vivo
series title
Advances in Neurobiology
editor
Choi, In-Young and Gruetter, Rolf
volume
4
pages
655 - 673
ISSN
2190-5223
2190-5215
ISBN
9781461417880
9781461417873
DOI
10.1007/978-1-4614-1788-0_20
language
English
LU publication?
no
id
9ba45880-ac1d-4d18-84c6-39eec9028c25
date added to LUP
2019-02-22 09:29:58
date last changed
2023-04-18 17:36:06
@inbook{9ba45880-ac1d-4d18-84c6-39eec9028c25,
  abstract     = {{Cerebral glucose homeostasis is maintained by the equilibrium between glucose transport across the blood-brain-barrier (BBB), which occurs through facilitative carriers, and glucose consumption mainly initiated by hexokinase phosphorylation. Glucose concentrations can be quantified non invasively by nuclear magnetic resonance (NMR) spectroscopy and such measurements, through appropriate mathematical modelling, allow to determine the kinetics of glucose transport and metabolism. This chapter summarizes the insights gained into brain glucose transport from the measurement of the brain glucose concentration, particularly reviewing state of the art NMR methods for non invasive determination of glucose homeostasis and discussing the employment of mathematical models of glucose transport.}},
  author       = {{Duarte, Joao and Gruetter, Rolf}},
  booktitle    = {{Neural Metabolism In Vivo}},
  editor       = {{Choi, In-Young and Gruetter, Rolf}},
  isbn         = {{9781461417880}},
  issn         = {{2190-5223}},
  language     = {{eng}},
  pages        = {{655--673}},
  series       = {{Advances in Neurobiology}},
  title        = {{Cerebral Glucose Transport and Homeostasis}},
  url          = {{http://dx.doi.org/10.1007/978-1-4614-1788-0_20}},
  doi          = {{10.1007/978-1-4614-1788-0_20}},
  volume       = {{4}},
  year         = {{2012}},
}