Chronic nicotine treatment eliminates asymmetry in striatal glucose utilization following unilateral transection of the mesostriatal dopamine pathway in rats
(1989) In Neuroscience Letters 102(2-3). p.279-283- Abstract
- Partial hemitransection was performed through a knife lesion at the meso-diencephalic level in rats to sever the mesostriatal dopamine system. During the subsequent 2 weeks the animals received 0.125 mg/kg/h of nicotine continuously via an osmotic minipump implanted s.c. To achieve prompt high nicotine levels, 4 i.p. injections of 0.5 mg/kg nicotine were, in addition, given during the first 2 h following the lesion. The total treatment corresponded to a mean plasma level of 50 ng/ml nicotine, measured at the end of the experiment. Control animals received corresponding volumes of 0.9% saline. Quantitative autoradiographic analysis of the glucose utilization in the caudate nucleus using Sokoloff's [14C]2-deoxyglucose method demonstrated a... (More)
- Partial hemitransection was performed through a knife lesion at the meso-diencephalic level in rats to sever the mesostriatal dopamine system. During the subsequent 2 weeks the animals received 0.125 mg/kg/h of nicotine continuously via an osmotic minipump implanted s.c. To achieve prompt high nicotine levels, 4 i.p. injections of 0.5 mg/kg nicotine were, in addition, given during the first 2 h following the lesion. The total treatment corresponded to a mean plasma level of 50 ng/ml nicotine, measured at the end of the experiment. Control animals received corresponding volumes of 0.9% saline. Quantitative autoradiographic analysis of the glucose utilization in the caudate nucleus using Sokoloff's [14C]2-deoxyglucose method demonstrated a 16% side-to-side difference in the lesioned control animals, whereas the asymmetry was counteracted by the nicotine treatment. Although there was an overall tendency to a lower rate of glucose utilization (by 6%) in the nicotine-treated animals compared to the controls receiving saline only, the difference was not statistically significant. The eliminated asymmetry probably reflects an increased survival of the dopamine neurons and/or of striatal nerve cells on the lesioned side due to protective effects of nicotine resulting from desensitization of nicotinic-type cholinergic receptors following continuous administration of the drug. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1104660
- author
- Owman, Christer LU ; Fuxe, K ; Janson, A M and Kahrstrom, J
- organization
- publishing date
- 1989
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Dopamine, Rat, Caudate nucleus, Glucose utilization, Mesostriatal system, Partial hemitransection, Nicotine
- in
- Neuroscience Letters
- volume
- 102
- issue
- 2-3
- pages
- 279 - 283
- publisher
- Elsevier
- external identifiers
-
- pmid:2812507
- scopus:0024320344
- ISSN
- 0304-3940
- DOI
- 10.1016/0304-3940(89)90092-X
- language
- English
- LU publication?
- yes
- id
- 9ba817dc-b5f6-4760-ae0d-def51cdc0ddf (old id 1104660)
- date added to LUP
- 2016-04-01 12:07:59
- date last changed
- 2021-01-03 06:45:51
@article{9ba817dc-b5f6-4760-ae0d-def51cdc0ddf,
abstract = {{Partial hemitransection was performed through a knife lesion at the meso-diencephalic level in rats to sever the mesostriatal dopamine system. During the subsequent 2 weeks the animals received 0.125 mg/kg/h of nicotine continuously via an osmotic minipump implanted s.c. To achieve prompt high nicotine levels, 4 i.p. injections of 0.5 mg/kg nicotine were, in addition, given during the first 2 h following the lesion. The total treatment corresponded to a mean plasma level of 50 ng/ml nicotine, measured at the end of the experiment. Control animals received corresponding volumes of 0.9% saline. Quantitative autoradiographic analysis of the glucose utilization in the caudate nucleus using Sokoloff's [14C]2-deoxyglucose method demonstrated a 16% side-to-side difference in the lesioned control animals, whereas the asymmetry was counteracted by the nicotine treatment. Although there was an overall tendency to a lower rate of glucose utilization (by 6%) in the nicotine-treated animals compared to the controls receiving saline only, the difference was not statistically significant. The eliminated asymmetry probably reflects an increased survival of the dopamine neurons and/or of striatal nerve cells on the lesioned side due to protective effects of nicotine resulting from desensitization of nicotinic-type cholinergic receptors following continuous administration of the drug.}},
author = {{Owman, Christer and Fuxe, K and Janson, A M and Kahrstrom, J}},
issn = {{0304-3940}},
keywords = {{Dopamine; Rat; Caudate nucleus; Glucose utilization; Mesostriatal system; Partial hemitransection; Nicotine}},
language = {{eng}},
number = {{2-3}},
pages = {{279--283}},
publisher = {{Elsevier}},
series = {{Neuroscience Letters}},
title = {{Chronic nicotine treatment eliminates asymmetry in striatal glucose utilization following unilateral transection of the mesostriatal dopamine pathway in rats}},
url = {{http://dx.doi.org/10.1016/0304-3940(89)90092-X}},
doi = {{10.1016/0304-3940(89)90092-X}},
volume = {{102}},
year = {{1989}},
}