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Cerebellar physiology : links between microcircuitry properties and sensorimotor functions

Jörntell, Henrik LU (2017) In Journal of Physiology 595(1). p.11-27
Abstract

Existing knowledge of the cerebellar microcircuitry structure and physiology allows a rather detailed description of what it in itself can and cannot do. Combined with a known mapping of different cerebellar regions to afferent systems and motor output target structures, there are several constraints that can be used to describe how specific components of the cerebellar microcircuitry may work during sensorimotor control. In fact, as described in this review, the major factor that hampers further progress in understanding cerebellar function is the limited insights into the circuitry-level function of the targeted motor output systems and the nature of the information in the mossy fiber afferents. The cerebellar circuitry in itself is... (More)

Existing knowledge of the cerebellar microcircuitry structure and physiology allows a rather detailed description of what it in itself can and cannot do. Combined with a known mapping of different cerebellar regions to afferent systems and motor output target structures, there are several constraints that can be used to describe how specific components of the cerebellar microcircuitry may work during sensorimotor control. In fact, as described in this review, the major factor that hampers further progress in understanding cerebellar function is the limited insights into the circuitry-level function of the targeted motor output systems and the nature of the information in the mossy fiber afferents. The cerebellar circuitry in itself is here summarized as a gigantic associative memory element, primarily consisting of the parallel fiber synapses, whereas most other circuitry components, including the climbing fiber system, primarily has the role of maintaining activity balance in the intracerebellar and extracerebellar circuitry. The review explores the consistency of this novel interpretational framework with multiple diverse observations at the synaptic and microcircuitry level within the cerebellum. (Figure presented.).

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Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
cerebellum, climbing fiber, mossy fiber, motor control, neural information, neural representation, plasticity, purkinje cells
in
Journal of Physiology
volume
595
issue
1
pages
17 pages
publisher
The Physiological Society
external identifiers
  • scopus:84984706089
  • wos:000392021800005
ISSN
0022-3751
DOI
10.1113/JP272769
language
English
LU publication?
yes
id
9bc2332f-b085-4d0c-9264-de433f8ab215
date added to LUP
2017-02-23 09:10:48
date last changed
2018-01-07 11:52:05
@article{9bc2332f-b085-4d0c-9264-de433f8ab215,
  abstract     = {<p>Existing knowledge of the cerebellar microcircuitry structure and physiology allows a rather detailed description of what it in itself can and cannot do. Combined with a known mapping of different cerebellar regions to afferent systems and motor output target structures, there are several constraints that can be used to describe how specific components of the cerebellar microcircuitry may work during sensorimotor control. In fact, as described in this review, the major factor that hampers further progress in understanding cerebellar function is the limited insights into the circuitry-level function of the targeted motor output systems and the nature of the information in the mossy fiber afferents. The cerebellar circuitry in itself is here summarized as a gigantic associative memory element, primarily consisting of the parallel fiber synapses, whereas most other circuitry components, including the climbing fiber system, primarily has the role of maintaining activity balance in the intracerebellar and extracerebellar circuitry. The review explores the consistency of this novel interpretational framework with multiple diverse observations at the synaptic and microcircuitry level within the cerebellum. (Figure presented.).</p>},
  author       = {Jörntell, Henrik},
  issn         = {0022-3751},
  keyword      = {cerebellum,climbing fiber,mossy fiber,motor control,neural information,neural representation,plasticity,purkinje cells},
  language     = {eng},
  month        = {01},
  number       = {1},
  pages        = {11--27},
  publisher    = {The Physiological Society},
  series       = {Journal of Physiology},
  title        = {Cerebellar physiology : links between microcircuitry properties and sensorimotor functions},
  url          = {http://dx.doi.org/10.1113/JP272769},
  volume       = {595},
  year         = {2017},
}