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Pulmonary Emphysema Diagnosis with a Preclinical Small-Animal X-ray Dark-Field Scatter-Contrast Scanner

Yaroshenko, Andre ; Meinel, Felix G. ; Bech, Martin LU ; Tapfer, Arne ; Velroyen, Astrid ; Schleede, Simone ; Auweter, Sigrid ; Bohla, Alexander ; Yildirim, Ali Oe. and Nikolaou, Konstantin , et al. (2013) In Radiology 269(2). p.426-432
Abstract
Purpose: To test the hypothesis that the joint distribution of x-ray transmission and dark-field signals obtained with a compact cone-beam preclinical scanner with a polychromatic source can be used to diagnose pulmonary emphysema in ex vivo murine lungs. Materials and Methods: The animal care committee approved this study. Three excised murine lungs with pulmonary emphysema and three excised murine control lungs were imaged ex vivo by using a grating-based micro-computed tomographic (CT) scanner. To evaluate the diagnostic value, the natural logarithm of relative transmission and the natural logarithm of dark-field scatter signal were plotted on a per-pixel basis on a scatterplot. Probability density function was fit to the joint... (More)
Purpose: To test the hypothesis that the joint distribution of x-ray transmission and dark-field signals obtained with a compact cone-beam preclinical scanner with a polychromatic source can be used to diagnose pulmonary emphysema in ex vivo murine lungs. Materials and Methods: The animal care committee approved this study. Three excised murine lungs with pulmonary emphysema and three excised murine control lungs were imaged ex vivo by using a grating-based micro-computed tomographic (CT) scanner. To evaluate the diagnostic value, the natural logarithm of relative transmission and the natural logarithm of dark-field scatter signal were plotted on a per-pixel basis on a scatterplot. Probability density function was fit to the joint distribution by using principle component analysis. An emphysema map was calculated based on the fitted probability density function. Results: The two-dimensional scatterplot showed a characteristic difference between control and emphysematous lungs. Control lungs had lower average median logarithmic transmission (-0.29 vs -0.18, P = .1) and lower average dark-field signal (-0.54 vs -0.37, P = .1) than emphysematous lungs. The angle to the vertical axis of the fitted regions also varied significantly (7.8 degrees for control lungs vs 15.9 degrees for emphysematous lungs). The calculated emphysema distribution map showed good agreement with histologic findings. Conclusion: X-ray dark-field scatter images of murine lungs obtained with a preclinical scanner can be used in the diagnosis of pulmonary emphysema. (C) RSNA, 2013 (Less)
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Radiology
volume
269
issue
2
pages
426 - 432
publisher
Radiological Society of North America
external identifiers
  • wos:000326092100015
  • scopus:84886655806
  • pmid:23696682
ISSN
1527-1315
DOI
10.1148/radiol.13122413
language
English
LU publication?
yes
id
9be83b05-dc0a-4c09-b430-fe6435b4b8a0 (old id 4212648)
date added to LUP
2016-04-01 13:46:53
date last changed
2020-09-30 03:07:09
@article{9be83b05-dc0a-4c09-b430-fe6435b4b8a0,
  abstract     = {Purpose: To test the hypothesis that the joint distribution of x-ray transmission and dark-field signals obtained with a compact cone-beam preclinical scanner with a polychromatic source can be used to diagnose pulmonary emphysema in ex vivo murine lungs. Materials and Methods: The animal care committee approved this study. Three excised murine lungs with pulmonary emphysema and three excised murine control lungs were imaged ex vivo by using a grating-based micro-computed tomographic (CT) scanner. To evaluate the diagnostic value, the natural logarithm of relative transmission and the natural logarithm of dark-field scatter signal were plotted on a per-pixel basis on a scatterplot. Probability density function was fit to the joint distribution by using principle component analysis. An emphysema map was calculated based on the fitted probability density function. Results: The two-dimensional scatterplot showed a characteristic difference between control and emphysematous lungs. Control lungs had lower average median logarithmic transmission (-0.29 vs -0.18, P = .1) and lower average dark-field signal (-0.54 vs -0.37, P = .1) than emphysematous lungs. The angle to the vertical axis of the fitted regions also varied significantly (7.8 degrees for control lungs vs 15.9 degrees for emphysematous lungs). The calculated emphysema distribution map showed good agreement with histologic findings. Conclusion: X-ray dark-field scatter images of murine lungs obtained with a preclinical scanner can be used in the diagnosis of pulmonary emphysema. (C) RSNA, 2013},
  author       = {Yaroshenko, Andre and Meinel, Felix G. and Bech, Martin and Tapfer, Arne and Velroyen, Astrid and Schleede, Simone and Auweter, Sigrid and Bohla, Alexander and Yildirim, Ali Oe. and Nikolaou, Konstantin and Bamberg, Fabian and Eickelberg, Oliver and Reiser, Maximilian F. and Pfeiffer, Franz},
  issn         = {1527-1315},
  language     = {eng},
  number       = {2},
  pages        = {426--432},
  publisher    = {Radiological Society of North America},
  series       = {Radiology},
  title        = {Pulmonary Emphysema Diagnosis with a Preclinical Small-Animal X-ray Dark-Field Scatter-Contrast Scanner},
  url          = {http://dx.doi.org/10.1148/radiol.13122413},
  doi          = {10.1148/radiol.13122413},
  volume       = {269},
  year         = {2013},
}