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Gene-lifestyle interplay in type 2 diabetes

Franks, Paul W. LU and Merino, Jordi LU (2018) In Current Opinion in Genetics and Development 50. p.35-40
Abstract

Type 2 diabetes (T2D) is widespread, affecting the health of hundreds of millions worldwide. The disease results from the complex interplay of lifestyle factors acting on a backdrop of inherited DNA risk variants. Detecting and understanding biomarkers, whether genotypes or other downstream biological features that dictate a person's phenotypic response to different lifestyle exposures, may have tremendous utility in the prevention of T2D. Here, we explore (i) evidence of how human genetic adaptation to diverse local environments might interact with lifestyle factors in T2D, (ii) the key challenges facing the research area of gene × lifestyle interactions in T2D, and (iii) the solutions that might be pursued in future studies. Overall,... (More)

Type 2 diabetes (T2D) is widespread, affecting the health of hundreds of millions worldwide. The disease results from the complex interplay of lifestyle factors acting on a backdrop of inherited DNA risk variants. Detecting and understanding biomarkers, whether genotypes or other downstream biological features that dictate a person's phenotypic response to different lifestyle exposures, may have tremendous utility in the prevention of T2D. Here, we explore (i) evidence of how human genetic adaptation to diverse local environments might interact with lifestyle factors in T2D, (ii) the key challenges facing the research area of gene × lifestyle interactions in T2D, and (iii) the solutions that might be pursued in future studies. Overall, many preliminary examples of such interactions exist, but none is sufficient to have a major impact on clinical decision making. Future studies, integrating genetics and other biological markers into regulatory networks, are likely to be necessary to facilitate the integration of genomics into lifestyle medicine in T2D.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Current Opinion in Genetics and Development
volume
50
pages
6 pages
publisher
Elsevier
external identifiers
  • scopus:85042100153
ISSN
0959-437X
DOI
10.1016/j.gde.2018.02.001
language
English
LU publication?
yes
id
9bfe4630-126c-4065-bec7-44a4cab9cb07
date added to LUP
2018-03-05 07:58:38
date last changed
2018-05-29 12:11:24
@article{9bfe4630-126c-4065-bec7-44a4cab9cb07,
  abstract     = {<p>Type 2 diabetes (T2D) is widespread, affecting the health of hundreds of millions worldwide. The disease results from the complex interplay of lifestyle factors acting on a backdrop of inherited DNA risk variants. Detecting and understanding biomarkers, whether genotypes or other downstream biological features that dictate a person's phenotypic response to different lifestyle exposures, may have tremendous utility in the prevention of T2D. Here, we explore (i) evidence of how human genetic adaptation to diverse local environments might interact with lifestyle factors in T2D, (ii) the key challenges facing the research area of gene × lifestyle interactions in T2D, and (iii) the solutions that might be pursued in future studies. Overall, many preliminary examples of such interactions exist, but none is sufficient to have a major impact on clinical decision making. Future studies, integrating genetics and other biological markers into regulatory networks, are likely to be necessary to facilitate the integration of genomics into lifestyle medicine in T2D.</p>},
  author       = {Franks, Paul W. and Merino, Jordi},
  issn         = {0959-437X},
  language     = {eng},
  month        = {06},
  pages        = {35--40},
  publisher    = {Elsevier},
  series       = {Current Opinion in Genetics and Development},
  title        = {Gene-lifestyle interplay in type 2 diabetes},
  url          = {http://dx.doi.org/10.1016/j.gde.2018.02.001},
  volume       = {50},
  year         = {2018},
}