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Evaluation of cancer cell membrane-disruption property of poly(vinyl alcohol)–ursodeoxycholic acid using 3D cancer–stromal models with macrophages

Moroishi, Kazuki LU ; Hermodsson, Tova LU ; Greiff, Lennart LU ; Lindstedt, Malin LU orcid and Matsusaki, Michiya (2026) In Chemistry Letters 55(3).
Abstract

We developed a collagen microfiber-based 3D cancer tissue model that included monocytes. Using a sedimentation culture method, normal human dermal fibroblasts, endothelial cells, cancer cells, and THP-1 cells—that is, the human monocytes cell line—were cocultured under a high collagen density. THP-1 cells were differentiated into macrophages and showed M2-like polarization in the 3D tumor microenvironment. This model was further applicable to drug evaluation by demonstrating the pH-responsive cytotoxicity of poly(vinyl alcohol)–ursodeoxycholic acid15.

Please use this url to cite or link to this publication:
author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
3D cancer–stromal tissue, collagen microfiber (CMF), monocyte differentiation
in
Chemistry Letters
volume
55
issue
3
article number
upag029
publisher
Oxford University Press
external identifiers
  • scopus:105032402708
ISSN
0366-7022
DOI
10.1093/chemle/upag029
language
English
LU publication?
yes
additional info
Publisher Copyright: © The Author(s) 2026. Published by Oxford University Press on behalf of the Chemical Society of Japan. All rights reserved.
id
9c1c01a4-2fdc-4d3f-85dc-4411bf43b564
date added to LUP
2026-05-07 14:08:13
date last changed
2026-08-12 12:07:53
@article{9c1c01a4-2fdc-4d3f-85dc-4411bf43b564,
  abstract     = {{<p>We developed a collagen microfiber-based 3D cancer tissue model that included monocytes. Using a sedimentation culture method, normal human dermal fibroblasts, endothelial cells, cancer cells, and THP-1 cells—that is, the human monocytes cell line—were cocultured under a high collagen density. THP-1 cells were differentiated into macrophages and showed M2-like polarization in the 3D tumor microenvironment. This model was further applicable to drug evaluation by demonstrating the pH-responsive cytotoxicity of poly(vinyl alcohol)–ursodeoxycholic acid15.</p>}},
  author       = {{Moroishi, Kazuki and Hermodsson, Tova and Greiff, Lennart and Lindstedt, Malin and Matsusaki, Michiya}},
  issn         = {{0366-7022}},
  keywords     = {{3D cancer–stromal tissue; collagen microfiber (CMF); monocyte differentiation}},
  language     = {{eng}},
  month        = {{03}},
  number       = {{3}},
  publisher    = {{Oxford University Press}},
  series       = {{Chemistry Letters}},
  title        = {{Evaluation of cancer cell membrane-disruption property of poly(vinyl alcohol)–ursodeoxycholic acid using 3D cancer–stromal models with macrophages}},
  url          = {{http://dx.doi.org/10.1093/chemle/upag029}},
  doi          = {{10.1093/chemle/upag029}},
  volume       = {{55}},
  year         = {{2026}},
}