Biodegradation and biocompatability of a calcium sulphate-hydroxyapatite bone substitute.
(2004) In Journal of Bone and Joint Surgery: British Volume 86(1). p.120-125- Abstract
- An injectable material consisting of calcium sulphate mixed with hydroxyapatite was investigated as a possible alternative to autograft in the restoration of bone defects. The material was studied both in vitro in simulated body fluid (SBF) and in vivo when implanted in rat muscles and into the proximal tibiae of rabbits. Variation in the strength and weight of the material during ageing in SBF was measured. Tissue response, material resorption and bone ingrowth were studied in the animal models. A good tissue response was observed in both the rat muscles and rabbit tibiae without inflammatory reactions or the presence of fibrous tissue. Ageing in SBF showed that during the first week carbonated hydroxyapatite precipitated on the surfaces... (More)
- An injectable material consisting of calcium sulphate mixed with hydroxyapatite was investigated as a possible alternative to autograft in the restoration of bone defects. The material was studied both in vitro in simulated body fluid (SBF) and in vivo when implanted in rat muscles and into the proximal tibiae of rabbits. Variation in the strength and weight of the material during ageing in SBF was measured. Tissue response, material resorption and bone ingrowth were studied in the animal models. A good tissue response was observed in both the rat muscles and rabbit tibiae without inflammatory reactions or the presence of fibrous tissue. Ageing in SBF showed that during the first week carbonated hydroxyapatite precipitated on the surfaces of the material and this may enhance bone ingrowth. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/120687
- author
- Nilsson, M ; Wang, Jian-Sheng LU ; Wielanek, L ; Tanner, K E and Lidgren, Lars LU
- organization
- publishing date
- 2004
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Bone Substitutes, Biodegradation, Animals, Electron, Muscle, Rats, Rabbits, Skeletal: metabolism, Sprague-Dawley, Scanning, Tibia: metabolism, Calcium Sulfate: metabolism, Durapatite: metabolism, Microscopy
- in
- Journal of Bone and Joint Surgery: British Volume
- volume
- 86
- issue
- 1
- pages
- 120 - 125
- publisher
- British Editorial Society of Bone & Joint Surgery
- external identifiers
-
- wos:000188428700025
- pmid:14765879
- scopus:1642504390
- ISSN
- 2044-5377
- DOI
- 10.1302/0301-620X.86B1.14040
- language
- English
- LU publication?
- yes
- id
- 9c33554f-126e-4cb8-a31d-84460442e22b (old id 120687)
- alternative location
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=14765879&dopt=Abstract
- date added to LUP
- 2016-04-01 11:51:07
- date last changed
- 2022-04-28 20:55:47
@article{9c33554f-126e-4cb8-a31d-84460442e22b, abstract = {{An injectable material consisting of calcium sulphate mixed with hydroxyapatite was investigated as a possible alternative to autograft in the restoration of bone defects. The material was studied both in vitro in simulated body fluid (SBF) and in vivo when implanted in rat muscles and into the proximal tibiae of rabbits. Variation in the strength and weight of the material during ageing in SBF was measured. Tissue response, material resorption and bone ingrowth were studied in the animal models. A good tissue response was observed in both the rat muscles and rabbit tibiae without inflammatory reactions or the presence of fibrous tissue. Ageing in SBF showed that during the first week carbonated hydroxyapatite precipitated on the surfaces of the material and this may enhance bone ingrowth.}}, author = {{Nilsson, M and Wang, Jian-Sheng and Wielanek, L and Tanner, K E and Lidgren, Lars}}, issn = {{2044-5377}}, keywords = {{Bone Substitutes; Biodegradation; Animals; Electron; Muscle; Rats; Rabbits; Skeletal: metabolism; Sprague-Dawley; Scanning; Tibia: metabolism; Calcium Sulfate: metabolism; Durapatite: metabolism; Microscopy}}, language = {{eng}}, number = {{1}}, pages = {{120--125}}, publisher = {{British Editorial Society of Bone & Joint Surgery}}, series = {{Journal of Bone and Joint Surgery: British Volume}}, title = {{Biodegradation and biocompatability of a calcium sulphate-hydroxyapatite bone substitute.}}, url = {{http://dx.doi.org/10.1302/0301-620X.86B1.14040}}, doi = {{10.1302/0301-620X.86B1.14040}}, volume = {{86}}, year = {{2004}}, }