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Relationship between selected DNA polymorphisms and coronary artery disease complications

Wirtwein, Marcin; Melander, Olle LU ; Sjögren, Marketa LU ; Hoffmann, Michal; Narkiewicz, Krzysztof; Gruchala, Marcin and Sobiczewski, Wojciech (2017) In International Journal of Cardiology 228. p.814-820
Abstract

Background Coronary heart disease (CHD) development is complex in origin, with contributions from well-defined lifestyle and not well-determined genetic risk factors. The aim of this study is to report the relationship between certain SNPs and the risk of cardiovascular (CV) complications in patients with CAD confirmed by coronary angiography. Methods In the present study, 1345 subjects with CHD were included. The median follow-up period was 8.6 years. 19 SNPs were investigated for any association with Major Advanced CV Events (MACE), Acute Coronary Syndromes (ACS) and Revascularizations. We modeled the 19 SNPs as a multilocus genetic risk score (GRS19). Results During follow-up period, 245 participants died; 114 due to CV causes. A... (More)

Background Coronary heart disease (CHD) development is complex in origin, with contributions from well-defined lifestyle and not well-determined genetic risk factors. The aim of this study is to report the relationship between certain SNPs and the risk of cardiovascular (CV) complications in patients with CAD confirmed by coronary angiography. Methods In the present study, 1345 subjects with CHD were included. The median follow-up period was 8.6 years. 19 SNPs were investigated for any association with Major Advanced CV Events (MACE), Acute Coronary Syndromes (ACS) and Revascularizations. We modeled the 19 SNPs as a multilocus genetic risk score (GRS19). Results During follow-up period, 245 participants died; 114 due to CV causes. A fatal or non-fatal CV event occurred in 882 participants including 214 ACS, 578 revascularizations and 90 strokes. The alleles of the following SNPs: rs1746048 (CXCL12), rs9818870 (MRAS) and rs17114036 (PPAP2B) were associated with a higher risk of MACE and the alleles of SNPs rs1746048 (CXCL12) and rs1122608 (LDLR) were associated with a higher risk of revascularization. The alleles of rs12190287 (MRAS), rs121902287 (TCF21) and rs2259816 (HNF1a) were associated with a higher risk of ACS. Despite the lack of relationship between significant CAD and GRS19, in the top quartile of GRS19 there was significant relationship between GRS19 and combined endpoint, MACE, ACS, and revascularization. Conclusions Conclusions. The SNPs of CXCL12 and LDLR were associated with risk of revascularization and CXCL12, LPA, MRAS, and PPAP2B were associated with the risk of MACE. GRS19 determines CV complications in CAD patients with the highest genetic risk score values.

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organization
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type
Contribution to journal
publication status
published
subject
keywords
Coronary artery disease, DNA polymorphisms, Hypertension
in
International Journal of Cardiology
volume
228
pages
7 pages
publisher
Elsevier
external identifiers
  • scopus:84997496903
  • wos:000393408600128
ISSN
0167-5273
DOI
10.1016/j.ijcard.2016.11.060
language
English
LU publication?
yes
id
9c54ae53-8d4d-4ff9-850a-58d7f9bff0be
date added to LUP
2016-12-28 10:56:01
date last changed
2018-04-08 04:52:17
@article{9c54ae53-8d4d-4ff9-850a-58d7f9bff0be,
  abstract     = {<p>Background Coronary heart disease (CHD) development is complex in origin, with contributions from well-defined lifestyle and not well-determined genetic risk factors. The aim of this study is to report the relationship between certain SNPs and the risk of cardiovascular (CV) complications in patients with CAD confirmed by coronary angiography. Methods In the present study, 1345 subjects with CHD were included. The median follow-up period was 8.6 years. 19 SNPs were investigated for any association with Major Advanced CV Events (MACE), Acute Coronary Syndromes (ACS) and Revascularizations. We modeled the 19 SNPs as a multilocus genetic risk score (GRS19). Results During follow-up period, 245 participants died; 114 due to CV causes. A fatal or non-fatal CV event occurred in 882 participants including 214 ACS, 578 revascularizations and 90 strokes. The alleles of the following SNPs: rs1746048 (CXCL12), rs9818870 (MRAS) and rs17114036 (PPAP2B) were associated with a higher risk of MACE and the alleles of SNPs rs1746048 (CXCL12) and rs1122608 (LDLR) were associated with a higher risk of revascularization. The alleles of rs12190287 (MRAS), rs121902287 (TCF21) and rs2259816 (HNF1a) were associated with a higher risk of ACS. Despite the lack of relationship between significant CAD and GRS19, in the top quartile of GRS19 there was significant relationship between GRS19 and combined endpoint, MACE, ACS, and revascularization. Conclusions Conclusions. The SNPs of CXCL12 and LDLR were associated with risk of revascularization and CXCL12, LPA, MRAS, and PPAP2B were associated with the risk of MACE. GRS19 determines CV complications in CAD patients with the highest genetic risk score values.</p>},
  author       = {Wirtwein, Marcin and Melander, Olle and Sjögren, Marketa and Hoffmann, Michal and Narkiewicz, Krzysztof and Gruchala, Marcin and Sobiczewski, Wojciech},
  issn         = {0167-5273},
  keyword      = {Coronary artery disease,DNA polymorphisms,Hypertension},
  language     = {eng},
  month        = {02},
  pages        = {814--820},
  publisher    = {Elsevier},
  series       = {International Journal of Cardiology},
  title        = {Relationship between selected DNA polymorphisms and coronary artery disease complications},
  url          = {http://dx.doi.org/10.1016/j.ijcard.2016.11.060},
  volume       = {228},
  year         = {2017},
}