A new biodegradable patch for closure of atrial septal defect. An experimental study
(1992) In Scandinavian Journal of Thoracic and Cardiovascular Surgery 26(1). p.9-14- Abstract
Biodegradable patches made from polyhydroxybutyrate (PHB) were used to close experimentally induced atrial septal defect in six calves. The implants were evaluated after 3-12 months macroscopically and by light and scanning electron microscopy with regard to regeneration of tissue and degradation of the polymer. At implant degradation, complete endothelial layers facing the right and left atrium were observed, with a subendothelial layer of collagen and some smooth-muscle cells. The patch was degraded by polynucleated macrophages, and 12 months postoperatively no polymer material was identifiable at ordinary light microscopy, but in polarized light small particles of polymer with persisting foreign body reaction were still seen.... (More)
Biodegradable patches made from polyhydroxybutyrate (PHB) were used to close experimentally induced atrial septal defect in six calves. The implants were evaluated after 3-12 months macroscopically and by light and scanning electron microscopy with regard to regeneration of tissue and degradation of the polymer. At implant degradation, complete endothelial layers facing the right and left atrium were observed, with a subendothelial layer of collagen and some smooth-muscle cells. The patch was degraded by polynucleated macrophages, and 12 months postoperatively no polymer material was identifiable at ordinary light microscopy, but in polarized light small particles of polymer with persisting foreign body reaction were still seen. Scanning electron microscopy revealed a complete layer of surface cells with morphologic signs of endothelium. There was no shunt or sign of infection. Biodegradable PHB patches implanted in atrial septal defects in this experimental model thus prompted formation of regenerated tissue that macroscopically and microscopically resembled native atrial septal wall. The total degradation time exceeded 12 months.
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- author
- Malm, T LU ; Bowald, S ; Karacagil, S ; Bylock, A and Busch, C
- publishing date
- 1992
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Animals, Biodegradation, Environmental, Cattle, Heart Septal Defects, Atrial/pathology, Heart Septum/anatomy & histology, Hydroxybutyrates, Male, Materials Testing, Microscopy, Electron, Scanning, Prostheses and Implants, Regeneration
- in
- Scandinavian Journal of Thoracic and Cardiovascular Surgery
- volume
- 26
- issue
- 1
- pages
- 6 pages
- publisher
- Taylor & Francis
- external identifiers
-
- pmid:1529304
- scopus:0026579026
- ISSN
- 0036-5580
- DOI
- 10.3109/14017439209099047
- language
- English
- LU publication?
- no
- id
- 9c84477a-db37-4711-a271-1db9e8882afc
- date added to LUP
- 2018-12-05 15:32:22
- date last changed
- 2024-05-14 20:20:57
@article{9c84477a-db37-4711-a271-1db9e8882afc,
abstract = {{<p>Biodegradable patches made from polyhydroxybutyrate (PHB) were used to close experimentally induced atrial septal defect in six calves. The implants were evaluated after 3-12 months macroscopically and by light and scanning electron microscopy with regard to regeneration of tissue and degradation of the polymer. At implant degradation, complete endothelial layers facing the right and left atrium were observed, with a subendothelial layer of collagen and some smooth-muscle cells. The patch was degraded by polynucleated macrophages, and 12 months postoperatively no polymer material was identifiable at ordinary light microscopy, but in polarized light small particles of polymer with persisting foreign body reaction were still seen. Scanning electron microscopy revealed a complete layer of surface cells with morphologic signs of endothelium. There was no shunt or sign of infection. Biodegradable PHB patches implanted in atrial septal defects in this experimental model thus prompted formation of regenerated tissue that macroscopically and microscopically resembled native atrial septal wall. The total degradation time exceeded 12 months.</p>}},
author = {{Malm, T and Bowald, S and Karacagil, S and Bylock, A and Busch, C}},
issn = {{0036-5580}},
keywords = {{Animals; Biodegradation, Environmental; Cattle; Heart Septal Defects, Atrial/pathology; Heart Septum/anatomy & histology; Hydroxybutyrates; Male; Materials Testing; Microscopy, Electron, Scanning; Prostheses and Implants; Regeneration}},
language = {{eng}},
number = {{1}},
pages = {{9--14}},
publisher = {{Taylor & Francis}},
series = {{Scandinavian Journal of Thoracic and Cardiovascular Surgery}},
title = {{A new biodegradable patch for closure of atrial septal defect. An experimental study}},
url = {{http://dx.doi.org/10.3109/14017439209099047}},
doi = {{10.3109/14017439209099047}},
volume = {{26}},
year = {{1992}},
}