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Prevalence of heart failure and other risk factors among first-degree relatives of women with peripartum cardiomyopathy

Christiansen, Mia Nielsen; Køber, Lars; Torp-Pedersen, Christian; Smith, J. Gustav LU ; Gustafsson, Finn; Vejlstrup, Niels G.; Damm, Peter; Johansen, Marianne; Andersson, Charlotte and Ersbøll, Anne S. (2019) In Heart 105(14). p.1057-1062
Abstract

Objectives: Peripartum cardiomyopathy (PPCM) is a rare disease carrying a risk of death and chronic heart failure.It is unknown if women with PPCM have a family history of heart failure. We investigated the prevalence of heart failure and hypertension in first-degree relatives to women with PPCM. Methods: A cohort of 61 women with PPCM was identified through the nationwide Danish registers from 2005 to 2014, and each individual diagnosis of PPCM was validated through review of patient records. We excluded 13 women due to lack of data on relatives. In a case-control design, the 48 remaining women were matched (on age, year of childbirth, parity and number of siblings) to 477 birth-giving Danish women without heart failure. We obtained... (More)

Objectives: Peripartum cardiomyopathy (PPCM) is a rare disease carrying a risk of death and chronic heart failure.It is unknown if women with PPCM have a family history of heart failure. We investigated the prevalence of heart failure and hypertension in first-degree relatives to women with PPCM. Methods: A cohort of 61 women with PPCM was identified through the nationwide Danish registers from 2005 to 2014, and each individual diagnosis of PPCM was validated through review of patient records. We excluded 13 women due to lack of data on relatives. In a case-control design, the 48 remaining women were matched (on age, year of childbirth, parity and number of siblings) to 477 birth-giving Danish women without heart failure. We obtained information on first-degree relatives (parents and siblings) through the National Danish Registers. Results: The cohort of 48 women with PPCM had a mean age of 31 years (SD 6). The prevalence of heart failure in any first-degree relative was higher in women with PPCM, compared with controls (23% vs 10%, p=0.011). A first-degree relative with any cardiovascular diagnosis was not more frequent in women with PPCM versus controls (77% vs 70%, p=0.280), but for siblings only, any cardiovascular diagnosis was more frequent in siblings to women with PPCM (29% vs 16%, p=0.026). Conclusion: Having a first-degree relative with heart failure was significantly more frequent in a cohort of validated PPCM cases than in controls, supporting the notion of shared aetiology between PPCM and other forms of heart failure.

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Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
epidemiology, heart failure, pregnancy
in
Heart
volume
105
issue
14
pages
1057 - 1062
publisher
BMJ Publishing Group
external identifiers
  • scopus:85063532745
ISSN
1355-6037
DOI
10.1136/heartjnl-2018-314552
language
English
LU publication?
yes
id
9c9d846a-69df-4b7b-abbc-6aec74ae41cf
date added to LUP
2019-04-10 14:15:22
date last changed
2019-08-23 10:58:51
@article{9c9d846a-69df-4b7b-abbc-6aec74ae41cf,
  abstract     = {<p>Objectives: Peripartum cardiomyopathy (PPCM) is a rare disease carrying a risk of death and chronic heart failure.It is unknown if women with PPCM have a family history of heart failure. We investigated the prevalence of heart failure and hypertension in first-degree relatives to women with PPCM. Methods: A cohort of 61 women with PPCM was identified through the nationwide Danish registers from 2005 to 2014, and each individual diagnosis of PPCM was validated through review of patient records. We excluded 13 women due to lack of data on relatives. In a case-control design, the 48 remaining women were matched (on age, year of childbirth, parity and number of siblings) to 477 birth-giving Danish women without heart failure. We obtained information on first-degree relatives (parents and siblings) through the National Danish Registers. Results: The cohort of 48 women with PPCM had a mean age of 31 years (SD 6). The prevalence of heart failure in any first-degree relative was higher in women with PPCM, compared with controls (23% vs 10%, p=0.011). A first-degree relative with any cardiovascular diagnosis was not more frequent in women with PPCM versus controls (77% vs 70%, p=0.280), but for siblings only, any cardiovascular diagnosis was more frequent in siblings to women with PPCM (29% vs 16%, p=0.026). Conclusion: Having a first-degree relative with heart failure was significantly more frequent in a cohort of validated PPCM cases than in controls, supporting the notion of shared aetiology between PPCM and other forms of heart failure.</p>},
  author       = {Christiansen, Mia Nielsen and Køber, Lars and Torp-Pedersen, Christian and Smith, J. Gustav and Gustafsson, Finn and Vejlstrup, Niels G. and Damm, Peter and Johansen, Marianne and Andersson, Charlotte and Ersbøll, Anne S.},
  issn         = {1355-6037},
  keyword      = {epidemiology,heart failure,pregnancy},
  language     = {eng},
  number       = {14},
  pages        = {1057--1062},
  publisher    = {BMJ Publishing Group},
  series       = {Heart},
  title        = {Prevalence of heart failure and other risk factors among first-degree relatives of women with peripartum cardiomyopathy},
  url          = {http://dx.doi.org/10.1136/heartjnl-2018-314552},
  volume       = {105},
  year         = {2019},
}