Advanced

The epidemiology and clinical features of portal vein thrombosis : A multicentre study

Rajani, R.; Björnsson, E.; Bergquist, A.; Danielsson, Å; Gustavsson, A.; Grip, O. LU ; Melin, T. LU ; Sangfelt, P.; Wallerstedt, S. and Almer, S. (2010) In Alimentary Pharmacology and Therapeutics 32(9). p.1154-1162
Abstract

Background Reliable epidemiological data for portal vein thrombosis are lacking. Aims To investigate the incidence, prevalence and survival rates for patients with portal vein thrombosis. Methods Retrospective multicentre study of all patients registered with the diagnosis of portal vein thrombosis between 1995 and 2004. Results A total of 173 patients (median age 57 years, 93 men) with portal vein thrombosis were identified and followed up for a median of 2.5 years (range 0-9.7). The mean age-standardized incidence and prevalence rates were 0.7 per 100 000 per year and 3.7 per 100 000 inhabitants, respectively. Liver disease was present in 70 patients (40%), malignancy in 27%, thrombophilic factors in 22% and myeloproliferative... (More)

Background Reliable epidemiological data for portal vein thrombosis are lacking. Aims To investigate the incidence, prevalence and survival rates for patients with portal vein thrombosis. Methods Retrospective multicentre study of all patients registered with the diagnosis of portal vein thrombosis between 1995 and 2004. Results A total of 173 patients (median age 57 years, 93 men) with portal vein thrombosis were identified and followed up for a median of 2.5 years (range 0-9.7). The mean age-standardized incidence and prevalence rates were 0.7 per 100 000 per year and 3.7 per 100 000 inhabitants, respectively. Liver disease was present in 70 patients (40%), malignancy in 27%, thrombophilic factors in 22% and myeloproliferative disorders in 11%. Two or more risk factors were identified in 80 patients (46%). At diagnosis, 65% were put on anticoagulant therapy. Thrombolysis, TIPS, surgical shunting and liver transplantation were performed in 6, 3, 2 and 8 patients, respectively. The overall survival at 1 year and 5 years was 69% and 54%. In the absence of malignancy and cirrhosis, the survival was 92% and 76%, respectively. Conclusions The incidence and prevalence rates of portal vein thrombosis were 0.7 per 100 000 inhabitants per year and 3.7 per 100 000 inhabitants, respectively. Concurrent prothrombotic risk factors are common. The prognosis is variable and highly dependent on underlying disease.

(Less)
Please use this url to cite or link to this publication:
author
publishing date
type
Contribution to journal
publication status
published
subject
in
Alimentary Pharmacology and Therapeutics
volume
32
issue
9
pages
9 pages
publisher
Wiley-Blackwell
external identifiers
  • scopus:78649486390
ISSN
0269-2813
DOI
10.1111/j.1365-2036.2010.04454.x
language
English
LU publication?
no
id
9cb58a84-1947-4f5b-8bbc-01c6aca70bc4
date added to LUP
2019-08-07 13:27:53
date last changed
2019-08-09 15:00:36
@article{9cb58a84-1947-4f5b-8bbc-01c6aca70bc4,
  abstract     = {<p>Background Reliable epidemiological data for portal vein thrombosis are lacking. Aims To investigate the incidence, prevalence and survival rates for patients with portal vein thrombosis. Methods Retrospective multicentre study of all patients registered with the diagnosis of portal vein thrombosis between 1995 and 2004. Results A total of 173 patients (median age 57 years, 93 men) with portal vein thrombosis were identified and followed up for a median of 2.5 years (range 0-9.7). The mean age-standardized incidence and prevalence rates were 0.7 per 100 000 per year and 3.7 per 100 000 inhabitants, respectively. Liver disease was present in 70 patients (40%), malignancy in 27%, thrombophilic factors in 22% and myeloproliferative disorders in 11%. Two or more risk factors were identified in 80 patients (46%). At diagnosis, 65% were put on anticoagulant therapy. Thrombolysis, TIPS, surgical shunting and liver transplantation were performed in 6, 3, 2 and 8 patients, respectively. The overall survival at 1 year and 5 years was 69% and 54%. In the absence of malignancy and cirrhosis, the survival was 92% and 76%, respectively. Conclusions The incidence and prevalence rates of portal vein thrombosis were 0.7 per 100 000 inhabitants per year and 3.7 per 100 000 inhabitants, respectively. Concurrent prothrombotic risk factors are common. The prognosis is variable and highly dependent on underlying disease.</p>},
  author       = {Rajani, R. and Björnsson, E. and Bergquist, A. and Danielsson, Å and Gustavsson, A. and Grip, O. and Melin, T. and Sangfelt, P. and Wallerstedt, S. and Almer, S.},
  issn         = {0269-2813},
  language     = {eng},
  month        = {11},
  number       = {9},
  pages        = {1154--1162},
  publisher    = {Wiley-Blackwell},
  series       = {Alimentary Pharmacology and Therapeutics},
  title        = {The epidemiology and clinical features of portal vein thrombosis : A multicentre study},
  url          = {http://dx.doi.org/10.1111/j.1365-2036.2010.04454.x},
  volume       = {32},
  year         = {2010},
}