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Type 1 diabetes-related autoantibodies are rare in Alaska native populations.

Mohatt, J ; Gilliam, LK ; Bekris, L ; Ebbesson, S and Lernmark, Åke LU orcid (2002) In International Journal of Circumpolar Health 61(1). p.21-31
Abstract
OBJECTIVES: When clinical data were initially gathered from the Alaskan Eskimos in the 1950's, diabetes mellitus was noted to be quite rare. The prevalence of diabetes has increased significantly since that time, with rates of 10% reported recently in some Alaska native populations. Our goal was to understand the pathogenesis of diabetes among these groups, with the hypothesis that Alaskan Eskimos were predominantly affected by type 2 diabetes, not by latent autoimmune diabetes in adults (LADA). STUDY DESIGN: Population based case control study METHODS: We tested sera from subjects in two Eskimo villages for the presence of type 1 diabetes-related autoantibodies against glutamic acid decarboxylase (GAD65Ab) and tyrosine phosphatase-like... (More)
OBJECTIVES: When clinical data were initially gathered from the Alaskan Eskimos in the 1950's, diabetes mellitus was noted to be quite rare. The prevalence of diabetes has increased significantly since that time, with rates of 10% reported recently in some Alaska native populations. Our goal was to understand the pathogenesis of diabetes among these groups, with the hypothesis that Alaskan Eskimos were predominantly affected by type 2 diabetes, not by latent autoimmune diabetes in adults (LADA). STUDY DESIGN: Population based case control study METHODS: We tested sera from subjects in two Eskimo villages for the presence of type 1 diabetes-related autoantibodies against glutamic acid decarboxylase (GAD65Ab) and tyrosine phosphatase-like islet antigen-2 (IA-2Ab). RESULTS: Among subjects from one Inupiat village (#1) and one SiberianYup'ik village (#2), there were 21 subjects with diabetes mellitus (DM), 17 with impaired glucose tolerance (IGT), and 226 healthy controls with normal gluco (Less)
Please use this url to cite or link to this publication:
author
; ; ; and
publishing date
type
Contribution to journal
publication status
published
subject
in
International Journal of Circumpolar Health
volume
61
issue
1
pages
21 - 31
publisher
International Journal of Circumpolar Health
external identifiers
  • scopus:0036481342
ISSN
2242-3982
DOI
10.3402/ijch.v61i0.17402
language
English
LU publication?
no
id
9ce06c8b-94a5-4e24-8fcd-e9c2c4135f95 (old id 1124816)
alternative location
https://www.tandfonline.com/doi/abs/10.3402/ijch.v61i0.17402
date added to LUP
2016-04-01 12:23:11
date last changed
2022-02-26 06:22:23
@article{9ce06c8b-94a5-4e24-8fcd-e9c2c4135f95,
  abstract     = {{OBJECTIVES: When clinical data were initially gathered from the Alaskan Eskimos in the 1950's, diabetes mellitus was noted to be quite rare. The prevalence of diabetes has increased significantly since that time, with rates of 10% reported recently in some Alaska native populations. Our goal was to understand the pathogenesis of diabetes among these groups, with the hypothesis that Alaskan Eskimos were predominantly affected by type 2 diabetes, not by latent autoimmune diabetes in adults (LADA). STUDY DESIGN: Population based case control study METHODS: We tested sera from subjects in two Eskimo villages for the presence of type 1 diabetes-related autoantibodies against glutamic acid decarboxylase (GAD65Ab) and tyrosine phosphatase-like islet antigen-2 (IA-2Ab). RESULTS: Among subjects from one Inupiat village (#1) and one SiberianYup'ik village (#2), there were 21 subjects with diabetes mellitus (DM), 17 with impaired glucose tolerance (IGT), and 226 healthy controls with normal gluco}},
  author       = {{Mohatt, J and Gilliam, LK and Bekris, L and Ebbesson, S and Lernmark, Åke}},
  issn         = {{2242-3982}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{21--31}},
  publisher    = {{International Journal of Circumpolar Health}},
  series       = {{International Journal of Circumpolar Health}},
  title        = {{Type 1 diabetes-related autoantibodies are rare in Alaska native populations.}},
  url          = {{http://dx.doi.org/10.3402/ijch.v61i0.17402}},
  doi          = {{10.3402/ijch.v61i0.17402}},
  volume       = {{61}},
  year         = {{2002}},
}