Indication for oophorectomy during cytoreduction for intraperitoneal metastatic spread of colorectal or appendiceal origin
(2011) In The British journal of surgery 98(2). p.287-292- Abstract
BACKGROUND: The incidence of ovarian metastases at the time of peritoneal carcinomatosis, and the influence of such metastases on survival after cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC), are unknown.
METHODS: This retrospective analysis included 194 women subjected to CRS and HIPEC since 2001. The incidence of ovarian metastases, disease-free survival and disease-specific survival were analysed.
RESULTS: The histological diagnosis was colorectal cancer carcinomatosis in 108 patients, peritoneal mucinous carcinomatosis (PMCA) in 23 and disseminated peritoneal adenomucinosis (DPAM) in 63. Ninety-nine patients underwent oophorectomy during the HIPEC procedure. Ovarian metastases were... (More)
BACKGROUND: The incidence of ovarian metastases at the time of peritoneal carcinomatosis, and the influence of such metastases on survival after cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC), are unknown.
METHODS: This retrospective analysis included 194 women subjected to CRS and HIPEC since 2001. The incidence of ovarian metastases, disease-free survival and disease-specific survival were analysed.
RESULTS: The histological diagnosis was colorectal cancer carcinomatosis in 108 patients, peritoneal mucinous carcinomatosis (PMCA) in 23 and disseminated peritoneal adenomucinosis (DPAM) in 63. Ninety-nine patients underwent oophorectomy during the HIPEC procedure. Ovarian metastases were confirmed in at least 52 per cent of the patients. There was a significant difference in disease-free survival between women with or without ovarian metastases in both PMCA and DPAM groups (P = 0·044 and P = 0·010 respectively). No significant differences in survival were found in the group with colorectal cancer carcinomatosis.
CONCLUSION: When peritoneal carcinomatosis of colorectal or appendiceal origin is confirmed, at least 52 per cent of ovaries will have synchronous metastases. Disease-free survival after a HIPEC procedure for PMCA or DPAM is significantly lower in women with ovarian metastases. Oophorectomy during CRS for peritoneal carcinomatosis should be strongly considered.
(Less)
- author
- Evers, D J and Verwaal, V J LU
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- keywords
- Adenocarcinoma, Mucinous/drug therapy, Adult, Aged, Antineoplastic Combined Chemotherapy Protocols/administration & dosage, Appendiceal Neoplasms, Chemotherapy, Cancer, Regional Perfusion/methods, Colorectal Neoplasms, Disease-Free Survival, Female, Humans, Injections, Intraperitoneal, Kaplan-Meier Estimate, Middle Aged, Neoplasm Recurrence, Local/etiology, Ovarian Neoplasms/drug therapy, Ovariectomy/methods, Peritoneal Neoplasms/secondary, Retrospective Studies, Treatment Outcome, Young Adult
- in
- The British journal of surgery
- volume
- 98
- issue
- 2
- pages
- 287 - 292
- publisher
- Oxford University Press
- external identifiers
-
- scopus:78650617530
- pmid:21046680
- ISSN
- 1365-2168
- DOI
- 10.1002/bjs.7303
- language
- English
- LU publication?
- no
- id
- 9d014511-f566-4b7b-848c-b70e100c8f34
- date added to LUP
- 2022-04-05 11:19:28
- date last changed
- 2024-02-24 22:13:35
@article{9d014511-f566-4b7b-848c-b70e100c8f34,
abstract = {{<p>BACKGROUND: The incidence of ovarian metastases at the time of peritoneal carcinomatosis, and the influence of such metastases on survival after cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC), are unknown.</p><p>METHODS: This retrospective analysis included 194 women subjected to CRS and HIPEC since 2001. The incidence of ovarian metastases, disease-free survival and disease-specific survival were analysed.</p><p>RESULTS: The histological diagnosis was colorectal cancer carcinomatosis in 108 patients, peritoneal mucinous carcinomatosis (PMCA) in 23 and disseminated peritoneal adenomucinosis (DPAM) in 63. Ninety-nine patients underwent oophorectomy during the HIPEC procedure. Ovarian metastases were confirmed in at least 52 per cent of the patients. There was a significant difference in disease-free survival between women with or without ovarian metastases in both PMCA and DPAM groups (P = 0·044 and P = 0·010 respectively). No significant differences in survival were found in the group with colorectal cancer carcinomatosis.</p><p>CONCLUSION: When peritoneal carcinomatosis of colorectal or appendiceal origin is confirmed, at least 52 per cent of ovaries will have synchronous metastases. Disease-free survival after a HIPEC procedure for PMCA or DPAM is significantly lower in women with ovarian metastases. Oophorectomy during CRS for peritoneal carcinomatosis should be strongly considered.</p>}},
author = {{Evers, D J and Verwaal, V J}},
issn = {{1365-2168}},
keywords = {{Adenocarcinoma, Mucinous/drug therapy; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols/administration & dosage; Appendiceal Neoplasms; Chemotherapy, Cancer, Regional Perfusion/methods; Colorectal Neoplasms; Disease-Free Survival; Female; Humans; Injections, Intraperitoneal; Kaplan-Meier Estimate; Middle Aged; Neoplasm Recurrence, Local/etiology; Ovarian Neoplasms/drug therapy; Ovariectomy/methods; Peritoneal Neoplasms/secondary; Retrospective Studies; Treatment Outcome; Young Adult}},
language = {{eng}},
number = {{2}},
pages = {{287--292}},
publisher = {{Oxford University Press}},
series = {{The British journal of surgery}},
title = {{Indication for oophorectomy during cytoreduction for intraperitoneal metastatic spread of colorectal or appendiceal origin}},
url = {{http://dx.doi.org/10.1002/bjs.7303}},
doi = {{10.1002/bjs.7303}},
volume = {{98}},
year = {{2011}},
}