Circulating antipericyte autoantibodies: A Novel Modifier of Risk of Progression of Diabetic Retinopathy?
(2007) In Retina 27(2). p.211-215- Abstract
- Background: Antipericyte autoantibodies (APAAs) are present in high frequency among diabetic subjects with and without nonproliferative retinopathy. This study aimed to determine whether progression of retinopathy in type 2 diabetes was associated with the same medical risk factors in APAA-positive subjects as in APAA-negative subjects. Methods: Type 2 diabetic patients with nonproliferative diabetic retinopathy at baseline were followed prospectively for 2 years monitoring progression of retinopathy. Thirty-eight (21.7%) of 175 patients had progression in Early Treatment Diabetic Retinopathy Study grade by >= 2 steps in at least 1 eye. Serum APAAs were detected by immunofluorescence on tissue-cultured bovine retinal pericytes. Results:... (More)
- Background: Antipericyte autoantibodies (APAAs) are present in high frequency among diabetic subjects with and without nonproliferative retinopathy. This study aimed to determine whether progression of retinopathy in type 2 diabetes was associated with the same medical risk factors in APAA-positive subjects as in APAA-negative subjects. Methods: Type 2 diabetic patients with nonproliferative diabetic retinopathy at baseline were followed prospectively for 2 years monitoring progression of retinopathy. Thirty-eight (21.7%) of 175 patients had progression in Early Treatment Diabetic Retinopathy Study grade by >= 2 steps in at least 1 eye. Serum APAAs were detected by immunofluorescence on tissue-cultured bovine retinal pericytes. Results: Progression of retinopathy was associated with HbA(1c) level (P = 0.002), diabetes duration (P = 0.03), and albumin/creatinine ratio (P = 0.02) in APAA-negative subjects but not in APAA-positive subjects. The association between progression and APAAs was strongest in the upper quartile for HbA(1c) level (>8.0%), where 71.4% of patients negative for APAAs had progression of retinopathy while only 24.1 % of patients positive for APAAs had progression (P = 0.007). Conclusion: The results suggest that APAA presence is a modifier of risk of progression of retinopathy due to hyperglycemia and that it could be useful as a biochemical marker of risk of progression of diabetic retinopathy in type 2 diabetic patients with poor metabolic control. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/165808
- author
- Nayak, Ramesh ; Lynch, Kristian LU ; Gustavsson, Carin LU ; Kwok, Michael ; Farthing-Nayak, Pamela ; Agardh, Carl-David LU and Agardh, Elisabet LU
- organization
- publishing date
- 2007
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- circulating antipericyte autoantibodies, retinopathy, progression, type 2 diabetes
- in
- Retina
- volume
- 27
- issue
- 2
- pages
- 211 - 215
- publisher
- Lippincott Williams & Wilkins
- external identifiers
-
- wos:000246986100012
- scopus:33846958395
- ISSN
- 0275-004X
- language
- English
- LU publication?
- yes
- id
- 9d2b7a14-5cd0-4c58-8db6-e87407306ba2 (old id 165808)
- alternative location
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17290204&dopt=Abstract
- date added to LUP
- 2016-04-01 16:20:55
- date last changed
- 2022-01-28 19:06:44
@article{9d2b7a14-5cd0-4c58-8db6-e87407306ba2,
abstract = {{Background: Antipericyte autoantibodies (APAAs) are present in high frequency among diabetic subjects with and without nonproliferative retinopathy. This study aimed to determine whether progression of retinopathy in type 2 diabetes was associated with the same medical risk factors in APAA-positive subjects as in APAA-negative subjects. Methods: Type 2 diabetic patients with nonproliferative diabetic retinopathy at baseline were followed prospectively for 2 years monitoring progression of retinopathy. Thirty-eight (21.7%) of 175 patients had progression in Early Treatment Diabetic Retinopathy Study grade by >= 2 steps in at least 1 eye. Serum APAAs were detected by immunofluorescence on tissue-cultured bovine retinal pericytes. Results: Progression of retinopathy was associated with HbA(1c) level (P = 0.002), diabetes duration (P = 0.03), and albumin/creatinine ratio (P = 0.02) in APAA-negative subjects but not in APAA-positive subjects. The association between progression and APAAs was strongest in the upper quartile for HbA(1c) level (>8.0%), where 71.4% of patients negative for APAAs had progression of retinopathy while only 24.1 % of patients positive for APAAs had progression (P = 0.007). Conclusion: The results suggest that APAA presence is a modifier of risk of progression of retinopathy due to hyperglycemia and that it could be useful as a biochemical marker of risk of progression of diabetic retinopathy in type 2 diabetic patients with poor metabolic control.}},
author = {{Nayak, Ramesh and Lynch, Kristian and Gustavsson, Carin and Kwok, Michael and Farthing-Nayak, Pamela and Agardh, Carl-David and Agardh, Elisabet}},
issn = {{0275-004X}},
keywords = {{circulating antipericyte autoantibodies; retinopathy; progression; type 2 diabetes}},
language = {{eng}},
number = {{2}},
pages = {{211--215}},
publisher = {{Lippincott Williams & Wilkins}},
series = {{Retina}},
title = {{Circulating antipericyte autoantibodies: A Novel Modifier of Risk of Progression of Diabetic Retinopathy?}},
url = {{http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17290204&dopt=Abstract}},
volume = {{27}},
year = {{2007}},
}