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A framework for neural organoids, assembloids and transplantation studies

Pașca, Sergiu P. ; Arlotta, Paola ; Bateup, Helen S. ; Camp, J. Gray ; Cappello, Silvia ; Gage, Fred H. ; Knoblich, Jürgen A. ; Kriegstein, Arnold R. ; Lancaster, Madeline A. and Ming, Guo Li , et al. (2025) In Nature 639(8054). p.315-320
Abstract

As the field of neural organoids and assembloids expands, there is an emergent need for guidance and advice on designing, conducting and reporting experiments to increase the reproducibility and utility of these models. In this Perspective, we present a framework for the experimental process that encompasses ensuring the quality and integrity of human pluripotent stem cells, characterizing and manipulating neural cells in vitro, transplantation techniques and considerations for modelling human development, evolution and disease. As with all scientific endeavours, we advocate for rigorous experimental designs tailored to explicit scientific questions as well as transparent methodologies and data sharing to provide useful knowledge for... (More)

As the field of neural organoids and assembloids expands, there is an emergent need for guidance and advice on designing, conducting and reporting experiments to increase the reproducibility and utility of these models. In this Perspective, we present a framework for the experimental process that encompasses ensuring the quality and integrity of human pluripotent stem cells, characterizing and manipulating neural cells in vitro, transplantation techniques and considerations for modelling human development, evolution and disease. As with all scientific endeavours, we advocate for rigorous experimental designs tailored to explicit scientific questions as well as transparent methodologies and data sharing to provide useful knowledge for current research practices and for developing regulatory standards.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Nature
volume
639
issue
8054
pages
6 pages
publisher
Nature Publishing Group
external identifiers
  • scopus:86000295466
  • pmid:39653126
ISSN
0028-0836
DOI
10.1038/s41586-024-08487-6
language
English
LU publication?
yes
additional info
Publisher Copyright: © Springer Nature Limited 2024.
id
9d3bfad7-d1d7-4edb-b458-ca2bb052050f
date added to LUP
2025-06-25 10:37:12
date last changed
2025-07-09 13:04:28
@article{9d3bfad7-d1d7-4edb-b458-ca2bb052050f,
  abstract     = {{<p>As the field of neural organoids and assembloids expands, there is an emergent need for guidance and advice on designing, conducting and reporting experiments to increase the reproducibility and utility of these models. In this Perspective, we present a framework for the experimental process that encompasses ensuring the quality and integrity of human pluripotent stem cells, characterizing and manipulating neural cells in vitro, transplantation techniques and considerations for modelling human development, evolution and disease. As with all scientific endeavours, we advocate for rigorous experimental designs tailored to explicit scientific questions as well as transparent methodologies and data sharing to provide useful knowledge for current research practices and for developing regulatory standards.</p>}},
  author       = {{Pașca, Sergiu P. and Arlotta, Paola and Bateup, Helen S. and Camp, J. Gray and Cappello, Silvia and Gage, Fred H. and Knoblich, Jürgen A. and Kriegstein, Arnold R. and Lancaster, Madeline A. and Ming, Guo Li and Novarino, Gaia and Okano, Hideyuki and Parmar, Malin and Park, In Hyun and Reiner, Orly and Song, Hongjun and Studer, Lorenz and Takahashi, Jun and Temple, Sally and Testa, Giuseppe and Treutlein, Barbara and Vaccarino, Flora M. and Vanderhaeghen, Pierre and Young-Pearse, Tracy}},
  issn         = {{0028-0836}},
  language     = {{eng}},
  month        = {{03}},
  number       = {{8054}},
  pages        = {{315--320}},
  publisher    = {{Nature Publishing Group}},
  series       = {{Nature}},
  title        = {{A framework for neural organoids, assembloids and transplantation studies}},
  url          = {{http://dx.doi.org/10.1038/s41586-024-08487-6}},
  doi          = {{10.1038/s41586-024-08487-6}},
  volume       = {{639}},
  year         = {{2025}},
}