Imaging-based assessment of fatty acid composition in human bone marrow adipose tissue at 7 T : Method comparison and in vivo feasibility
Emin, Sevgi LU ; Oei, Edwin H.G. ; Englund, Martin LU
and Peterson, Pernilla
LU
(2023)
In Magnetic Resonance in Medicine
90(1).
p.240-249
- Abstract
Purpose: To demonstrate the feasibility and accuracy of chemical shift–encoded imaging of the fatty acid composition (FAC) of human bone marrow adipose tissue at 7 T, and to determine suitable image-acquisition parameters using simulations. Methods: The noise performance of FAC estimation was investigated using simulations with a range of inter-echo time, and accuracy was assessed using a phantom experiment. Furthermore, one knee of 8 knee-healthy subjects (ages 35–54 years) was imaged, and the fractions of saturated fatty acids (SFA) and polyunsaturated fatty acids (PUFA) were mapped. Values were compared between reconstruction methods, and between anatomical regions. Results: Based on simulations, ΔTE = 0.6 ms was chosen. The phantom... (More)
Purpose: To demonstrate the feasibility and accuracy of chemical shift–encoded imaging of the fatty acid composition (FAC) of human bone marrow adipose tissue at 7 T, and to determine suitable image-acquisition parameters using simulations. Methods: The noise performance of FAC estimation was investigated using simulations with a range of inter-echo time, and accuracy was assessed using a phantom experiment. Furthermore, one knee of 8 knee-healthy subjects (ages 35–54 years) was imaged, and the fractions of saturated fatty acids (SFA) and polyunsaturated fatty acids (PUFA) were mapped. Values were compared between reconstruction methods, and between anatomical regions. Results: Based on simulations, ΔTE = 0.6 ms was chosen. The phantom experiment demonstrated high accuracy of especially SFA using a constrained reconstruction model (slope = 1.1, average bias = −0.2%). The lowest accuracy was seen for PUFA using a free model (slope = 2.0, average bias = 9.0%). For in vivo images, the constrained model resulted in lower intersubject variation compared with the free model (e.g., in the femoral shaft, the SFA percent-point range was within 1.0% [vs. 3.0%]). Furthermore, significant regional FAC differences were detected. For example, using the constrained approach, the femoral SFA in the medial condyle was lower compared with the shaft (median [range]: 27.9% [27.1%, 28.4%] vs. 32.5% [31.8%, 32.8%]). Conclusion: Bone marrow adipose tissue FAC quantification using chemical-shift encoding is feasible at 7 T. Both the noise performance and accuracy of the technique are superior using a constrained signal model.
(Less)
- author
- Emin, Sevgi
LU
; Oei, Edwin H.G.
; Englund, Martin
LU
and Peterson, Pernilla
LU
- organization
- publishing date
- 2023
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- 7 T, bone marrow adipose tissue, chemical shift–encoded imaging, fatty acid composition, MRI
- in
- Magnetic Resonance in Medicine
- volume
- 90
- issue
- 1
- pages
- 240 - 249
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- scopus:85149913782
- ISSN
- 0740-3194
- DOI
- 10.1002/mrm.29623
- language
- English
- LU publication?
- yes
- id
- 9d4a3fc0-058b-46ad-a155-4ae6f9f302b4
- date added to LUP
- 2023-04-06 12:38:07
- date last changed
- 2023-10-26 14:48:54
@article{9d4a3fc0-058b-46ad-a155-4ae6f9f302b4,
abstract = {{<p>Purpose: To demonstrate the feasibility and accuracy of chemical shift–encoded imaging of the fatty acid composition (FAC) of human bone marrow adipose tissue at 7 T, and to determine suitable image-acquisition parameters using simulations. Methods: The noise performance of FAC estimation was investigated using simulations with a range of inter-echo time, and accuracy was assessed using a phantom experiment. Furthermore, one knee of 8 knee-healthy subjects (ages 35–54 years) was imaged, and the fractions of saturated fatty acids (SFA) and polyunsaturated fatty acids (PUFA) were mapped. Values were compared between reconstruction methods, and between anatomical regions. Results: Based on simulations, ΔTE = 0.6 ms was chosen. The phantom experiment demonstrated high accuracy of especially SFA using a constrained reconstruction model (slope = 1.1, average bias = −0.2%). The lowest accuracy was seen for PUFA using a free model (slope = 2.0, average bias = 9.0%). For in vivo images, the constrained model resulted in lower intersubject variation compared with the free model (e.g., in the femoral shaft, the SFA percent-point range was within 1.0% [vs. 3.0%]). Furthermore, significant regional FAC differences were detected. For example, using the constrained approach, the femoral SFA in the medial condyle was lower compared with the shaft (median [range]: 27.9% [27.1%, 28.4%] vs. 32.5% [31.8%, 32.8%]). Conclusion: Bone marrow adipose tissue FAC quantification using chemical-shift encoding is feasible at 7 T. Both the noise performance and accuracy of the technique are superior using a constrained signal model.</p>}},
author = {{Emin, Sevgi and Oei, Edwin H.G. and Englund, Martin and Peterson, Pernilla}},
issn = {{0740-3194}},
keywords = {{7 T; bone marrow adipose tissue; chemical shift–encoded imaging; fatty acid composition; MRI}},
language = {{eng}},
number = {{1}},
pages = {{240--249}},
publisher = {{John Wiley & Sons Inc.}},
series = {{Magnetic Resonance in Medicine}},
title = {{Imaging-based assessment of fatty acid composition in human bone marrow adipose tissue at 7 T : Method comparison and in vivo feasibility}},
url = {{http://dx.doi.org/10.1002/mrm.29623}},
doi = {{10.1002/mrm.29623}},
volume = {{90}},
year = {{2023}},
}