Molecular regulation of differentiation in early B-lymphocyte development
(2018) In International Journal of Molecular Sciences 19(7).- Abstract
B-lymphocyte differentiation is one of the best understood developmental pathways in the hematopoietic system. Our understanding of the developmental trajectories linking the multipotent hematopoietic stem cell to the mature functional B-lymphocyte is extensive as a result of efforts to identify and prospectively isolate progenitors at defined maturation stages. The identification of defined progenitor compartments has been instrumental for the resolution of the molecular features that defines given developmental stages as well as for our understanding of the mechanisms that drive the progressive maturation process. Over the last years it has become increasingly clear that the regulatory networks that control normal B-cell... (More)
B-lymphocyte differentiation is one of the best understood developmental pathways in the hematopoietic system. Our understanding of the developmental trajectories linking the multipotent hematopoietic stem cell to the mature functional B-lymphocyte is extensive as a result of efforts to identify and prospectively isolate progenitors at defined maturation stages. The identification of defined progenitor compartments has been instrumental for the resolution of the molecular features that defines given developmental stages as well as for our understanding of the mechanisms that drive the progressive maturation process. Over the last years it has become increasingly clear that the regulatory networks that control normal B-cell differentiation are targeted by mutations in human B-lineage malignancies. This generates a most interesting link between development and disease that can be explored to improve diagnosis and treatment protocols in lymphoid malignancies. The aim of this review is to provide an overview of our current understanding of molecular regulation in normal and malignant B-cell development.
(Less)
- author
- Sigvardsson, Mikael LU
- organization
- publishing date
- 2018-07-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- B-lymphocyte, Development, Lymphoid leukemia, Transcription factors
- in
- International Journal of Molecular Sciences
- volume
- 19
- issue
- 7
- article number
- 1928
- publisher
- MDPI AG
- external identifiers
-
- pmid:29966360
- scopus:85049427332
- ISSN
- 1661-6596
- DOI
- 10.3390/ijms19071928
- language
- English
- LU publication?
- yes
- id
- 9d884114-f94a-470a-9e7b-0708e7d15624
- date added to LUP
- 2018-07-23 13:40:23
- date last changed
- 2024-05-27 14:28:10
@article{9d884114-f94a-470a-9e7b-0708e7d15624,
abstract = {{<p>B-lymphocyte differentiation is one of the best understood developmental pathways in the hematopoietic system. Our understanding of the developmental trajectories linking the multipotent hematopoietic stem cell to the mature functional B-lymphocyte is extensive as a result of efforts to identify and prospectively isolate progenitors at defined maturation stages. The identification of defined progenitor compartments has been instrumental for the resolution of the molecular features that defines given developmental stages as well as for our understanding of the mechanisms that drive the progressive maturation process. Over the last years it has become increasingly clear that the regulatory networks that control normal B-cell differentiation are targeted by mutations in human B-lineage malignancies. This generates a most interesting link between development and disease that can be explored to improve diagnosis and treatment protocols in lymphoid malignancies. The aim of this review is to provide an overview of our current understanding of molecular regulation in normal and malignant B-cell development.</p>}},
author = {{Sigvardsson, Mikael}},
issn = {{1661-6596}},
keywords = {{B-lymphocyte; Development; Lymphoid leukemia; Transcription factors}},
language = {{eng}},
month = {{07}},
number = {{7}},
publisher = {{MDPI AG}},
series = {{International Journal of Molecular Sciences}},
title = {{Molecular regulation of differentiation in early B-lymphocyte development}},
url = {{http://dx.doi.org/10.3390/ijms19071928}},
doi = {{10.3390/ijms19071928}},
volume = {{19}},
year = {{2018}},
}