Successful aging : Insights from proteome analyses of healthy centenarians
(2020) In Aging 12(4). p.3502-3515- Abstract
Healthy aging depends on a complex gene-environment network that is ultimately reflected in the expression of different proteins. We aimed to perform a comparative analysis of the plasma proteome of healthy centenarians (n=9, 5 women, age range 100-103 years) with a notably preserved ambulatory capacity (as a paradigm of 'successful' aging), and control individuals who died from a major age-related disease before the expected life expectancy (n=9, 5 women, age range: 67-81 years), and while having impaired ambulatory capacity (as a paradigm of 'unsuccessful' aging). We found that the expression of 49 proteins and 86 pathways differed between the two groups. Overall, healthy centenarians presented with distinct expression of... (More)
Healthy aging depends on a complex gene-environment network that is ultimately reflected in the expression of different proteins. We aimed to perform a comparative analysis of the plasma proteome of healthy centenarians (n=9, 5 women, age range 100-103 years) with a notably preserved ambulatory capacity (as a paradigm of 'successful' aging), and control individuals who died from a major age-related disease before the expected life expectancy (n=9, 5 women, age range: 67-81 years), and while having impaired ambulatory capacity (as a paradigm of 'unsuccessful' aging). We found that the expression of 49 proteins and 86 pathways differed between the two groups. Overall, healthy centenarians presented with distinct expression of proteins/pathways that reflect a healthy immune function, including a lower pro-inflammatory status (less 'inflammaging' and autoimmunity) and a preserved humoral immune response (increased B cell-mediated immune response). Compared with controls, healthy centenarians also presented with a higher expression of proteins involved in angiogenesis and related to enhanced intercellular junctions, as well as a lower expression of proteins involved in cardiovascular abnormalities. The identification of these proteins/pathways might provide new insights into the biological mechanisms underlying the paradigm of healthy aging.
(Less)
- author
- organization
- publishing date
- 2020-02-29
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Elderly, Healthy aging, Immune system, Proteomics, Senescence
- in
- Aging
- volume
- 12
- issue
- 4
- pages
- 3502 - 3515
- publisher
- Impact Journals
- external identifiers
-
- scopus:85081945245
- pmid:32100723
- ISSN
- 1945-4589
- DOI
- 10.18632/aging.102826
- language
- English
- LU publication?
- yes
- id
- 9dafb9db-5c56-4069-9431-7f516d3f4bfb
- date added to LUP
- 2020-11-03 16:59:45
- date last changed
- 2024-04-03 15:30:42
@article{9dafb9db-5c56-4069-9431-7f516d3f4bfb,
abstract = {{<p>Healthy aging depends on a complex gene-environment network that is ultimately reflected in the expression of different proteins. We aimed to perform a comparative analysis of the plasma proteome of healthy centenarians (n=9, 5 women, age range 100-103 years) with a notably preserved ambulatory capacity (as a paradigm of 'successful' aging), and control individuals who died from a major age-related disease before the expected life expectancy (n=9, 5 women, age range: 67-81 years), and while having impaired ambulatory capacity (as a paradigm of 'unsuccessful' aging). We found that the expression of 49 proteins and 86 pathways differed between the two groups. Overall, healthy centenarians presented with distinct expression of proteins/pathways that reflect a healthy immune function, including a lower pro-inflammatory status (less 'inflammaging' and autoimmunity) and a preserved humoral immune response (increased B cell-mediated immune response). Compared with controls, healthy centenarians also presented with a higher expression of proteins involved in angiogenesis and related to enhanced intercellular junctions, as well as a lower expression of proteins involved in cardiovascular abnormalities. The identification of these proteins/pathways might provide new insights into the biological mechanisms underlying the paradigm of healthy aging.</p>}},
author = {{Santos-Lozano, Alejandro and Valenzuela, Pedro L. and Llavero, Francisco and Lista, Simone and Carrera-Bastos, Pedro and Hampel, Harald and Pareja-Galeano, Helios and Gálvez, Beatriz G. and López, Juan Antonio and Vázquez, Jesús and Emanuele, Enzo and Zugaza, José L. and Lucia, Alejandro}},
issn = {{1945-4589}},
keywords = {{Elderly; Healthy aging; Immune system; Proteomics; Senescence}},
language = {{eng}},
month = {{02}},
number = {{4}},
pages = {{3502--3515}},
publisher = {{Impact Journals}},
series = {{Aging}},
title = {{Successful aging : Insights from proteome analyses of healthy centenarians}},
url = {{http://dx.doi.org/10.18632/aging.102826}},
doi = {{10.18632/aging.102826}},
volume = {{12}},
year = {{2020}},
}