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The Evaluation of Optic Nerves Using 7 Tesla “Silent” Zero Echo Time Imaging in Patients with Leber’s Hereditary Optic Neuropathy with or without Idebenone Treatment

Grochowski, Cezary ; Symms, Mark ; Jonak, Kamil ; Krukow, Paweł ; Wood, Tobias C ; Ljungberg, Emil LU orcid ; Enseñat, Joaquim ; Nowomiejska, Katarzyna ; Rejdak, Robert and Maciejewski, Ryszard , et al. (2020) In Journal of Clinical Medicine 9(4).
Abstract
Magnetic Resonance Imaging (MRI) of the Optic Nerve is difficult due to the fine extended nature of the structure, strong local magnetic field distortions induced by anatomy, and large motion artefacts associated with eye movement. To address these problems we used a Zero Echo Time (ZTE) MRI sequence with an Adiabatic SPectral Inversion Recovery (ASPIR) fat suppression pulse which also imbues the images with Magnetisation Transfer contrast. We investigated an application of the sequence for imaging the optic nerve in subjects with Leber’s hereditary optic neuropathy (LHON). Of particular note is the sequence’s near-silent operation, which can enhance image quality of the optic nerve by reducing the occurrence of involuntary saccades... (More)
Magnetic Resonance Imaging (MRI) of the Optic Nerve is difficult due to the fine extended nature of the structure, strong local magnetic field distortions induced by anatomy, and large motion artefacts associated with eye movement. To address these problems we used a Zero Echo Time (ZTE) MRI sequence with an Adiabatic SPectral Inversion Recovery (ASPIR) fat suppression pulse which also imbues the images with Magnetisation Transfer contrast. We investigated an application of the sequence for imaging the optic nerve in subjects with Leber’s hereditary optic neuropathy (LHON). Of particular note is the sequence’s near-silent operation, which can enhance image quality of the optic nerve by reducing the occurrence of involuntary saccades induced during Magnetic Resonance (MR) scanning. (Less)
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publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Clinical Medicine
volume
9
issue
4
article number
1112
publisher
MDPI AG
external identifiers
  • scopus:85102992761
ISSN
2077-0383
DOI
10.3390/jcm9041112
language
English
LU publication?
no
id
9dc6c93c-484c-4d08-8929-27a9fec2526e
date added to LUP
2023-05-01 14:14:12
date last changed
2025-04-04 14:57:49
@article{9dc6c93c-484c-4d08-8929-27a9fec2526e,
  abstract     = {{Magnetic Resonance Imaging (MRI) of the Optic Nerve is difficult due to the fine extended nature of the structure, strong local magnetic field distortions induced by anatomy, and large motion artefacts associated with eye movement. To address these problems we used a Zero Echo Time (ZTE) MRI sequence with an Adiabatic SPectral Inversion Recovery (ASPIR) fat suppression pulse which also imbues the images with Magnetisation Transfer contrast. We investigated an application of the sequence for imaging the optic nerve in subjects with Leber’s hereditary optic neuropathy (LHON). Of particular note is the sequence’s near-silent operation, which can enhance image quality of the optic nerve by reducing the occurrence of involuntary saccades induced during Magnetic Resonance (MR) scanning.}},
  author       = {{Grochowski, Cezary and Symms, Mark and Jonak, Kamil and Krukow, Paweł and Wood, Tobias C and Ljungberg, Emil and Enseñat, Joaquim and Nowomiejska, Katarzyna and Rejdak, Robert and Maciejewski, Ryszard and Barker, Gareth J.}},
  issn         = {{2077-0383}},
  language     = {{eng}},
  month        = {{04}},
  number       = {{4}},
  publisher    = {{MDPI AG}},
  series       = {{Journal of Clinical Medicine}},
  title        = {{The Evaluation of Optic Nerves Using 7 Tesla “Silent” Zero Echo Time Imaging in Patients with Leber’s Hereditary Optic Neuropathy with or without Idebenone Treatment}},
  url          = {{http://dx.doi.org/10.3390/jcm9041112}},
  doi          = {{10.3390/jcm9041112}},
  volume       = {{9}},
  year         = {{2020}},
}