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A survey on thromboprophylaxis and coagulation assessment in children and young adults with acute lymphoblastic leukaemia (ALL) in the Nordic and Baltic countries : Different practices of assessment and management

Andersson, Nadine G. LU ; Rathe, Mathias ; Mølle, Ingolf ; Jarvis, Kirsten Brunswig ; Hoffmann, Marianne ; Huurre, Anu ; Joelsson, Joel ; Albertsen, Birgitte Klug ; Lohi, Olli and Långström, Satu , et al. (2022) In British Journal of Haematology 199(1). p.117-121
Abstract

Patients undergoing treatment for acute lymphoblastic leukaemia (ALL) are at risk of coagulopathy, especially thromboembolism. We conducted a survey on practices in the assessment and management of coagulopathy during the new ALLTogether protocol in 29 (17 paediatric, 12 adult) Nordic and Baltic cancer centres. While 92% of adult centres used thromboprophylaxis with low-molecular-weight heparin, no paediatric centre did. Almost all providers performed baseline coagulation studies, but only 59% continued the assessment. Fibrinogen replacement was conducted in 59%, and antithrombin replacement in 28% of the centres. The survey highlights the need for guidelines in the management of coagulopathy during ALL therapy.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
ALL, antithrombin, childhood leukaemia, paediatric haemostasis, paediatric thrombosis, thrombosis
in
British Journal of Haematology
volume
199
issue
1
pages
5 pages
publisher
Wiley-Blackwell
external identifiers
  • pmid:35922061
  • scopus:85135264603
ISSN
0007-1048
DOI
10.1111/bjh.18397
language
English
LU publication?
yes
id
9e13d780-9b6b-4064-93a5-4283a5f48bcc
date added to LUP
2022-11-29 14:38:04
date last changed
2024-04-14 17:46:15
@article{9e13d780-9b6b-4064-93a5-4283a5f48bcc,
  abstract     = {{<p>Patients undergoing treatment for acute lymphoblastic leukaemia (ALL) are at risk of coagulopathy, especially thromboembolism. We conducted a survey on practices in the assessment and management of coagulopathy during the new ALLTogether protocol in 29 (17 paediatric, 12 adult) Nordic and Baltic cancer centres. While 92% of adult centres used thromboprophylaxis with low-molecular-weight heparin, no paediatric centre did. Almost all providers performed baseline coagulation studies, but only 59% continued the assessment. Fibrinogen replacement was conducted in 59%, and antithrombin replacement in 28% of the centres. The survey highlights the need for guidelines in the management of coagulopathy during ALL therapy.</p>}},
  author       = {{Andersson, Nadine G. and Rathe, Mathias and Mølle, Ingolf and Jarvis, Kirsten Brunswig and Hoffmann, Marianne and Huurre, Anu and Joelsson, Joel and Albertsen, Birgitte Klug and Lohi, Olli and Långström, Satu and Overgaard, Ulrik and Saulyte Trakymiene, Sonata and Vepsäläinen, Kaisa and Vogt, Hartmut and Ranta, Susanna}},
  issn         = {{0007-1048}},
  keywords     = {{ALL; antithrombin; childhood leukaemia; paediatric haemostasis; paediatric thrombosis; thrombosis}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{117--121}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{British Journal of Haematology}},
  title        = {{A survey on thromboprophylaxis and coagulation assessment in children and young adults with acute lymphoblastic leukaemia (ALL) in the Nordic and Baltic countries : Different practices of assessment and management}},
  url          = {{http://dx.doi.org/10.1111/bjh.18397}},
  doi          = {{10.1111/bjh.18397}},
  volume       = {{199}},
  year         = {{2022}},
}