Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Energetics of the DNA-Filled Head

Evilevitch, Alex LU orcid (2021) 4. p.1-8
Abstract
Mechanical changes within cells and viruses have been shown to be of great importance for various mechano-signaling processes. In phage and herpesviruses, strong confinement of double-stranded DNA inside the capsid generates tens of atmospheres of pressure. This confinement leads to electrostatic sliding friction between neighboring DNA strands. This affects the mobility of the encapsidated genome which directly impacts the dynamics of viral DNA ejection during infection. When a cell is infected by multiple virions, the dynamics of release of viral genomes into a cell leads to competitive interactions between viral genomes, which in turn influences viral gene expression. This affects cell’s “decision” between lysogeny (dormant state where... (More)
Mechanical changes within cells and viruses have been shown to be of great importance for various mechano-signaling processes. In phage and herpesviruses, strong confinement of double-stranded DNA inside the capsid generates tens of atmospheres of pressure. This confinement leads to electrostatic sliding friction between neighboring DNA strands. This affects the mobility of the encapsidated genome which directly impacts the dynamics of viral DNA ejection during infection. When a cell is infected by multiple virions, the dynamics of release of viral genomes into a cell leads to competitive interactions between viral genomes, which in turn influences viral gene expression. This affects cell’s “decision” between lysogeny (dormant state where virus does not replicate) and cell lysis caused by lytic virus replication. This article reviews the energetics, structure and mobility of the intra-capsid genome, influenced by changes in physiological parameters (temperature and ionic conditions) that are important for viral replication. The mechano-regulation of DNA ejection dynamics is also analyzed and placed in the context of viral replication dynamics. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
host publication
Reference Module in Life Sciences
volume
4
pages
1 - 8
publisher
Elsevier
DOI
10.1016/B978-0-12-809633-8.21519-7
language
English
LU publication?
yes
id
9e259916-85bb-49d8-80e6-b4d791b3b187
date added to LUP
2020-05-20 23:24:21
date last changed
2021-04-17 23:17:26
@inbook{9e259916-85bb-49d8-80e6-b4d791b3b187,
  abstract     = {{Mechanical changes within cells and viruses have been shown to be of great importance for various mechano-signaling processes. In phage and herpesviruses, strong confinement of double-stranded DNA inside the capsid generates tens of atmospheres of pressure. This confinement leads to electrostatic sliding friction between neighboring DNA strands. This affects the mobility of the encapsidated genome which directly impacts the dynamics of viral DNA ejection during infection. When a cell is infected by multiple virions, the dynamics of release of viral genomes into a cell leads to competitive interactions between viral genomes, which in turn influences viral gene expression. This affects cell’s “decision” between lysogeny (dormant state where virus does not replicate) and cell lysis caused by lytic virus replication. This article reviews the energetics, structure and mobility of the intra-capsid genome, influenced by changes in physiological parameters (temperature and ionic conditions) that are important for viral replication. The mechano-regulation of DNA ejection dynamics is also analyzed and placed in the context of viral replication dynamics.}},
  author       = {{Evilevitch, Alex}},
  booktitle    = {{Reference Module in Life Sciences}},
  language     = {{eng}},
  pages        = {{1--8}},
  publisher    = {{Elsevier}},
  title        = {{Energetics of the DNA-Filled Head}},
  url          = {{http://dx.doi.org/10.1016/B978-0-12-809633-8.21519-7}},
  doi          = {{10.1016/B978-0-12-809633-8.21519-7}},
  volume       = {{4}},
  year         = {{2021}},
}