Associations of Interleukin-5 With Plaque Development and Cardiovascular Events
Knutsson, Anki LU ; Björkbacka, Harry LU
; Dunér, Pontus
LU
; Engström, Gunnar
LU
; Binder, Christoph J.
; Nilsson, Anna Hultgårdh
LU
and Nilsson, Jan
LU
(2019)
In JACC: Basic to Translational Science
4(8).
p.891-902
- Abstract
Experimental studies have suggested an atheroprotective role of interleukin (IL)-5 through the stimulation of natural immunoglobulin M antibody expression. In the present study we show that there are no associations between baseline levels of IL-5 and risk for development of coronary events or stroke during a 15.7 ± 6.3 years follow-up of 696 subjects randomly sampled from the Malmö Diet and Cancer study. However, presence of a plaque at the carotid bifurcation was associated with lower IL-5 and IL-5 deficiency resulted in increased plaque development at sites of oscillatory blood flow in Apoe−/− mice suggesting a protective role for IL-5 in plaque development.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/9e38b917-ec10-48bb-8e5d-df924453ff41
- author
- Knutsson, Anki
LU
; Björkbacka, Harry
LU
; Dunér, Pontus
LU
; Engström, Gunnar
LU
; Binder, Christoph J.
; Nilsson, Anna Hultgårdh
LU
and Nilsson, Jan
LU
- organization
-
- Vessel Wall Biology (research group)
- Cardiovascular Research - Cellular Metabolism and Inflammation (research group)
- EXODIAB: Excellence of Diabetes Research in Sweden
- Cardiovascular Research - Matrix and Inflammation in Atherosclerosis (research group)
- Cardiovascular Research - Epidemiology (research group)
- EpiHealth: Epidemiology for Health
- Cardiovascular Research - Immunity and Atherosclerosis (research group)
- publishing date
- 2019
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- atherosclerosis, interleukin 5, myocardial infarction, stroke
- in
- JACC: Basic to Translational Science
- volume
- 4
- issue
- 8
- pages
- 12 pages
- publisher
- Elsevier
- external identifiers
-
- pmid:31909299
- scopus:85076709493
- ISSN
- 2452-302X
- DOI
- 10.1016/j.jacbts.2019.07.002
- language
- English
- LU publication?
- yes
- id
- 9e38b917-ec10-48bb-8e5d-df924453ff41
- date added to LUP
- 2020-01-07 13:03:56
- date last changed
- 2024-05-01 03:12:19
@article{9e38b917-ec10-48bb-8e5d-df924453ff41,
abstract = {{<p>Experimental studies have suggested an atheroprotective role of interleukin (IL)-5 through the stimulation of natural immunoglobulin M antibody expression. In the present study we show that there are no associations between baseline levels of IL-5 and risk for development of coronary events or stroke during a 15.7 ± 6.3 years follow-up of 696 subjects randomly sampled from the Malmö Diet and Cancer study. However, presence of a plaque at the carotid bifurcation was associated with lower IL-5 and IL-5 deficiency resulted in increased plaque development at sites of oscillatory blood flow in Apoe<sup>−/−</sup> mice suggesting a protective role for IL-5 in plaque development.</p>}},
author = {{Knutsson, Anki and Björkbacka, Harry and Dunér, Pontus and Engström, Gunnar and Binder, Christoph J. and Nilsson, Anna Hultgårdh and Nilsson, Jan}},
issn = {{2452-302X}},
keywords = {{atherosclerosis; interleukin 5; myocardial infarction; stroke}},
language = {{eng}},
number = {{8}},
pages = {{891--902}},
publisher = {{Elsevier}},
series = {{JACC: Basic to Translational Science}},
title = {{Associations of Interleukin-5 With Plaque Development and Cardiovascular Events}},
url = {{http://dx.doi.org/10.1016/j.jacbts.2019.07.002}},
doi = {{10.1016/j.jacbts.2019.07.002}},
volume = {{4}},
year = {{2019}},
}