Modeling of Kidney Hemodynamics : Probability-Based Topology of an Arterial Network
Postnov, Dmitry D. ; Marsh, Donald J. ; Postnov, Dmitry E. ; Braunstein, Thomas H. ; Holstein-Rathlou, Niels Henrik ; Martens, Erik A. LU
and Sosnovtseva, Olga
(2016)
In PLoS Computational Biology
12(7).
- Abstract
Through regulation of the extracellular fluid volume, the kidneys provide important long-term regulation of blood pressure. At the level of the individual functional unit (the nephron), pressure and flow control involves two different mechanisms that both produce oscillations. The nephrons are arranged in a complex branching structure that delivers blood to each nephron and, at the same time, provides a basis for an interaction between adjacent nephrons. The functional consequences of this interaction are not understood, and at present it is not possible to address this question experimentally. We provide experimental data and a new modeling approach to clarify this problem. To resolve details of microvascular structure, we collected 3D... (More)
Through regulation of the extracellular fluid volume, the kidneys provide important long-term regulation of blood pressure. At the level of the individual functional unit (the nephron), pressure and flow control involves two different mechanisms that both produce oscillations. The nephrons are arranged in a complex branching structure that delivers blood to each nephron and, at the same time, provides a basis for an interaction between adjacent nephrons. The functional consequences of this interaction are not understood, and at present it is not possible to address this question experimentally. We provide experimental data and a new modeling approach to clarify this problem. To resolve details of microvascular structure, we collected 3D data from more than 150 afferent arterioles in an optically cleared rat kidney. Using these results together with published micro-computed tomography (μCT) data we develop an algorithm for generating the renal arterial network. We then introduce a mathematical model describing blood flow dynamics and nephron to nephron interaction in the network. The model includes an implementation of electrical signal propagation along a vascular wall. Simulation results show that the renal arterial architecture plays an important role in maintaining adequate pressure levels and the self-sustained dynamics of nephrons.
(Less)
- author
- Postnov, Dmitry D.
; Marsh, Donald J.
; Postnov, Dmitry E.
; Braunstein, Thomas H.
; Holstein-Rathlou, Niels Henrik
; Martens, Erik A.
LU
and Sosnovtseva, Olga
- publishing date
- 2016-07
- type
- Contribution to journal
- publication status
- published
- in
- PLoS Computational Biology
- volume
- 12
- issue
- 7
- article number
- e1004922
- publisher
- Public Library of Science (PLoS)
- external identifiers
-
- pmid:27447287
- scopus:84980037535
- ISSN
- 1553-734X
- DOI
- 10.1371/journal.pcbi.1004922
- language
- English
- LU publication?
- no
- additional info
- Publisher Copyright: © 2016 Postnov et al. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.
- id
- 9e3ed918-b613-4ac1-98d8-e2d585ba379d
- date added to LUP
- 2021-03-19 21:25:08
- date last changed
- 2024-04-20 04:11:22
@article{9e3ed918-b613-4ac1-98d8-e2d585ba379d,
abstract = {{<p>Through regulation of the extracellular fluid volume, the kidneys provide important long-term regulation of blood pressure. At the level of the individual functional unit (the nephron), pressure and flow control involves two different mechanisms that both produce oscillations. The nephrons are arranged in a complex branching structure that delivers blood to each nephron and, at the same time, provides a basis for an interaction between adjacent nephrons. The functional consequences of this interaction are not understood, and at present it is not possible to address this question experimentally. We provide experimental data and a new modeling approach to clarify this problem. To resolve details of microvascular structure, we collected 3D data from more than 150 afferent arterioles in an optically cleared rat kidney. Using these results together with published micro-computed tomography (μCT) data we develop an algorithm for generating the renal arterial network. We then introduce a mathematical model describing blood flow dynamics and nephron to nephron interaction in the network. The model includes an implementation of electrical signal propagation along a vascular wall. Simulation results show that the renal arterial architecture plays an important role in maintaining adequate pressure levels and the self-sustained dynamics of nephrons.</p>}},
author = {{Postnov, Dmitry D. and Marsh, Donald J. and Postnov, Dmitry E. and Braunstein, Thomas H. and Holstein-Rathlou, Niels Henrik and Martens, Erik A. and Sosnovtseva, Olga}},
issn = {{1553-734X}},
language = {{eng}},
number = {{7}},
publisher = {{Public Library of Science (PLoS)}},
series = {{PLoS Computational Biology}},
title = {{Modeling of Kidney Hemodynamics : Probability-Based Topology of an Arterial Network}},
url = {{http://dx.doi.org/10.1371/journal.pcbi.1004922}},
doi = {{10.1371/journal.pcbi.1004922}},
volume = {{12}},
year = {{2016}},
}