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Comparison of contrast-to-noise ratios of transmission and dark-field signal in grating-based X-ray imaging for healthy murine lung tissue

Schwab, Felix ; Schleede, Simone ; Hahn, Dieter ; Bech, Martin LU orcid ; Herzen, Julia ; Auweter, Sigrid ; Bamberg, Fabian ; Achterhold, Klaus ; Yildirim, Ali Oe. and Bohla, Alexander , et al. (2013) In Zeitschrift für Medizinische Physik 23(3). p.236-242
Abstract
Purpose: An experimental comparison of the contrast-to-noise ratio (CNR) between transmission and dark-field signals in grating-based X-ray imaging for ex-vivo murine lung tissue. Materials and Methods: Lungs from three healthy mice were imaged ex vivo using a laser-driven compact synchrotron X-ray source. Background noise of transmission and dark-field signal was quantified by measuring the standard deviation in a region of interest (ROI) placed in a homogeneous area outside the specimen. Image contrast was quantified by measuring the signal range in rectangular ROIs placed in central and peripheral lung parenchyma. The relative contrast gain (RCG) of dark-field over transmission images was calculated as CNRDF /CNRT. Results: In all... (More)
Purpose: An experimental comparison of the contrast-to-noise ratio (CNR) between transmission and dark-field signals in grating-based X-ray imaging for ex-vivo murine lung tissue. Materials and Methods: Lungs from three healthy mice were imaged ex vivo using a laser-driven compact synchrotron X-ray source. Background noise of transmission and dark-field signal was quantified by measuring the standard deviation in a region of interest (ROI) placed in a homogeneous area outside the specimen. Image contrast was quantified by measuring the signal range in rectangular ROIs placed in central and peripheral lung parenchyma. The relative contrast gain (RCG) of dark-field over transmission images was calculated as CNRDF /CNRT. Results: In all images, there was a trend for contrast-to-noise ratios of dark-field images (CNRDF) to be higher than for transmission images (CNRT) for all ROIs (median 61 vs. 38, p = 0.10), but the difference was statistically significant only for peripheral ROIs (61 vs. 32, p = 0.03). Median RCG was >1 for all Rats (1.84). RCG values were significantly smaller for central ROIs than for peripheral ROIs (1.34 vs. 2.43, p = 0.03). Conclusion: The contrast-to-noise ratio of dark-field images compares more favorably to the contrast-to-noise ratio of transmission images for peripheral lung regions as compared to central regions. For any specific specimen, a calculation of the RCG allows comparing which X-ray modality (dark-field or transmission imaging) produces better contrast-to-noise characteristics in a well-defined ROI. (Less)
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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Image contrast, lung imaging, X-ray phase-contrast imaging, X-ray, dark-field imaging
in
Zeitschrift für Medizinische Physik
volume
23
issue
3
pages
236 - 242
publisher
Elsevier
external identifiers
  • wos:000324081300009
  • scopus:84881556200
  • pmid:23219282
ISSN
1876-4436
DOI
10.1016/j.zemedi.2012.11.003
language
English
LU publication?
yes
id
9e700271-388e-42c1-b4cc-accc2cc657b5 (old id 4112906)
date added to LUP
2016-04-01 09:52:37
date last changed
2022-02-09 20:31:33
@article{9e700271-388e-42c1-b4cc-accc2cc657b5,
  abstract     = {{Purpose: An experimental comparison of the contrast-to-noise ratio (CNR) between transmission and dark-field signals in grating-based X-ray imaging for ex-vivo murine lung tissue. Materials and Methods: Lungs from three healthy mice were imaged ex vivo using a laser-driven compact synchrotron X-ray source. Background noise of transmission and dark-field signal was quantified by measuring the standard deviation in a region of interest (ROI) placed in a homogeneous area outside the specimen. Image contrast was quantified by measuring the signal range in rectangular ROIs placed in central and peripheral lung parenchyma. The relative contrast gain (RCG) of dark-field over transmission images was calculated as CNRDF /CNRT. Results: In all images, there was a trend for contrast-to-noise ratios of dark-field images (CNRDF) to be higher than for transmission images (CNRT) for all ROIs (median 61 vs. 38, p = 0.10), but the difference was statistically significant only for peripheral ROIs (61 vs. 32, p = 0.03). Median RCG was >1 for all Rats (1.84). RCG values were significantly smaller for central ROIs than for peripheral ROIs (1.34 vs. 2.43, p = 0.03). Conclusion: The contrast-to-noise ratio of dark-field images compares more favorably to the contrast-to-noise ratio of transmission images for peripheral lung regions as compared to central regions. For any specific specimen, a calculation of the RCG allows comparing which X-ray modality (dark-field or transmission imaging) produces better contrast-to-noise characteristics in a well-defined ROI.}},
  author       = {{Schwab, Felix and Schleede, Simone and Hahn, Dieter and Bech, Martin and Herzen, Julia and Auweter, Sigrid and Bamberg, Fabian and Achterhold, Klaus and Yildirim, Ali Oe. and Bohla, Alexander and Eickelberg, Oliver and Loewen, Rod and Gifford, Martin and Ruth, Ronald and Reiser, Maximilian F. and Nikolaou, Konstantin and Pfeiffer, Franz and Meinel, Felix G.}},
  issn         = {{1876-4436}},
  keywords     = {{Image contrast; lung imaging; X-ray phase-contrast imaging; X-ray; dark-field imaging}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{236--242}},
  publisher    = {{Elsevier}},
  series       = {{Zeitschrift für Medizinische Physik}},
  title        = {{Comparison of contrast-to-noise ratios of transmission and dark-field signal in grating-based X-ray imaging for healthy murine lung tissue}},
  url          = {{http://dx.doi.org/10.1016/j.zemedi.2012.11.003}},
  doi          = {{10.1016/j.zemedi.2012.11.003}},
  volume       = {{23}},
  year         = {{2013}},
}