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Propofol increased the interleukin-6 to interleukin-10 ratio more than isoflurane after surgery in long-term alcoholic patients

Von Dossow, V ; Baur, S ; Sander, M ; Tønnesen, H LU ; Marks, C ; Paschen, C ; Berger, G and Spies, C D (2007) In Journal of International Medical Research 35(3). p.395-405
Abstract
This study investigated the effect of an anaesthetic regimen on the immune response in 40 long-term alcoholic patients undergoing surgery. Patients were randomly allocated to receive either propofol or isoflurane during surgery. Plasma cytokines interleukin (IL)-6 and IL-10 were measured at defined times and rates of post-operative infections were documented. The IL-6/IL-10 ratio significantly increased with propofol compared with isoflurane on day 1 after surgery and the IL-10 level significantly increased with isoflurane on day 1 after surgery. The overall post-operative infection rate was significantly higher in isoflurane-treated patients. Our findings indicate that propofol anaesthesia might be the more favourable regimen, with the... (More)
This study investigated the effect of an anaesthetic regimen on the immune response in 40 long-term alcoholic patients undergoing surgery. Patients were randomly allocated to receive either propofol or isoflurane during surgery. Plasma cytokines interleukin (IL)-6 and IL-10 were measured at defined times and rates of post-operative infections were documented. The IL-6/IL-10 ratio significantly increased with propofol compared with isoflurane on day 1 after surgery and the IL-10 level significantly increased with isoflurane on day 1 after surgery. The overall post-operative infection rate was significantly higher in isoflurane-treated patients. Our findings indicate that propofol anaesthesia might be the more favourable regimen, with the IL-6/IL-10 ratio indicating an attenuation of the immune imbalance after surgery in long-term alcoholic patients. These results support the undertaking of a properly powered clinical trial to determine if propofol anaesthesia can reduce the postoperative infection rate in this special patient population. (Less)
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publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of International Medical Research
volume
35
issue
3
pages
11 pages
publisher
SAGE Publications
external identifiers
  • scopus:34250841763
ISSN
0300-0605
DOI
10.1177/147323000703500315
language
English
LU publication?
no
id
9eab85b4-a8b4-4680-936f-9a7d1a5bc761
date added to LUP
2018-12-06 15:50:25
date last changed
2022-01-31 07:44:18
@article{9eab85b4-a8b4-4680-936f-9a7d1a5bc761,
  abstract     = {{This study investigated the effect of an anaesthetic regimen on the immune response in 40 long-term alcoholic patients undergoing surgery. Patients were randomly allocated to receive either propofol or isoflurane during surgery. Plasma cytokines interleukin (IL)-6 and IL-10 were measured at defined times and rates of post-operative infections were documented. The IL-6/IL-10 ratio significantly increased with propofol compared with isoflurane on day 1 after surgery and the IL-10 level significantly increased with isoflurane on day 1 after surgery. The overall post-operative infection rate was significantly higher in isoflurane-treated patients. Our findings indicate that propofol anaesthesia might be the more favourable regimen, with the IL-6/IL-10 ratio indicating an attenuation of the immune imbalance after surgery in long-term alcoholic patients. These results support the undertaking of a properly powered clinical trial to determine if propofol anaesthesia can reduce the postoperative infection rate in this special patient population.}},
  author       = {{Von Dossow, V and Baur, S and Sander, M and Tønnesen, H and Marks, C and Paschen, C and Berger, G and Spies, C D}},
  issn         = {{0300-0605}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{395--405}},
  publisher    = {{SAGE Publications}},
  series       = {{Journal of International Medical Research}},
  title        = {{Propofol increased the interleukin-6 to interleukin-10 ratio more than isoflurane after surgery in long-term alcoholic patients}},
  url          = {{http://dx.doi.org/10.1177/147323000703500315}},
  doi          = {{10.1177/147323000703500315}},
  volume       = {{35}},
  year         = {{2007}},
}