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Effects of high-intensity focused ultrasound on the intervertebral disc: A potential therapy for disc herniations

Forslund, Carina LU ; Persson, Johan K LU ; Strömqvist, Björn LU ; Lidgren, Lars LU and McCarthy, Ian LU (2006) In Journal of Clinical Ultrasound 34(7). p.330-338
Abstract
Purpose. To determine the potential application of high-intensity focused ultrasound for the minimally invasive treatment of herniated intervertebral discs by developing a probe that produces sufficiently high temperature locally to shrink collagen fibers (65-75 degrees C). Materials and Methods. A 5-mm ultrasound probe was produced with a geometric focal length of 15 mm. The probe produced 2.5 W of acoustic power and was operated at a frequency of 4.1 MHz. Measurements of temperature increase were performed in discs from bovine tails. In vivo experiments were performed to assess histologic changes in the disc as well as in nerve root and muscle. Results. Sufficient temperature increase to produce collagen shrinkage was observed close to... (More)
Purpose. To determine the potential application of high-intensity focused ultrasound for the minimally invasive treatment of herniated intervertebral discs by developing a probe that produces sufficiently high temperature locally to shrink collagen fibers (65-75 degrees C). Materials and Methods. A 5-mm ultrasound probe was produced with a geometric focal length of 15 mm. The probe produced 2.5 W of acoustic power and was operated at a frequency of 4.1 MHz. Measurements of temperature increase were performed in discs from bovine tails. In vivo experiments were performed to assess histologic changes in the disc as well as in nerve root and muscle. Results. Sufficient temperature increase to produce collagen shrinkage was observed close to the focus of the ultrasound. Temperature measurements in vertebral end plates showed a temperature increase of only 4 degrees C after 60-second exposure of the disc. In vivo experiments revealed histologic changes in the disc consistent with collagen shrinkage, with no adverse effects seen in surrounding tissues. Conclusions. The experiments demonstrated the feasibility of high-intensity focused ultrasound in the treatment of contained herniated discs. This technique has several advantages over other thermal treatment modalities. (C) 2006 Wiley Periodicals, Inc. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
thermal therapy, HIFU, disc herniation
in
Journal of Clinical Ultrasound
volume
34
issue
7
pages
330 - 338
publisher
John Wiley & Sons
external identifiers
  • wos:000240521400003
  • scopus:33748069438
ISSN
0091-2751
DOI
10.1002/jcu.20242
language
English
LU publication?
yes
id
9ed50d89-e51d-4ece-b13d-ed9b5b241d98 (old id 394097)
date added to LUP
2007-10-02 21:01:05
date last changed
2019-02-20 07:56:25
@article{9ed50d89-e51d-4ece-b13d-ed9b5b241d98,
  abstract     = {Purpose. To determine the potential application of high-intensity focused ultrasound for the minimally invasive treatment of herniated intervertebral discs by developing a probe that produces sufficiently high temperature locally to shrink collagen fibers (65-75 degrees C). Materials and Methods. A 5-mm ultrasound probe was produced with a geometric focal length of 15 mm. The probe produced 2.5 W of acoustic power and was operated at a frequency of 4.1 MHz. Measurements of temperature increase were performed in discs from bovine tails. In vivo experiments were performed to assess histologic changes in the disc as well as in nerve root and muscle. Results. Sufficient temperature increase to produce collagen shrinkage was observed close to the focus of the ultrasound. Temperature measurements in vertebral end plates showed a temperature increase of only 4 degrees C after 60-second exposure of the disc. In vivo experiments revealed histologic changes in the disc consistent with collagen shrinkage, with no adverse effects seen in surrounding tissues. Conclusions. The experiments demonstrated the feasibility of high-intensity focused ultrasound in the treatment of contained herniated discs. This technique has several advantages over other thermal treatment modalities. (C) 2006 Wiley Periodicals, Inc.},
  author       = {Forslund, Carina and Persson, Johan K and Strömqvist, Björn and Lidgren, Lars and McCarthy, Ian},
  issn         = {0091-2751},
  keyword      = {thermal therapy,HIFU,disc herniation},
  language     = {eng},
  number       = {7},
  pages        = {330--338},
  publisher    = {John Wiley & Sons},
  series       = {Journal of Clinical Ultrasound},
  title        = {Effects of high-intensity focused ultrasound on the intervertebral disc: A potential therapy for disc herniations},
  url          = {http://dx.doi.org/10.1002/jcu.20242},
  volume       = {34},
  year         = {2006},
}