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The androgen receptor gene CAG repeat in relation to 4-year changes in androgen-sensitive endpoints in community-dwelling older European men

Eendebak, Robert J A H; Huhtaniemi, Ilpo T.; Pye, Stephen R.; Ahern, Tomas; W O'Neill, Terence; Bartfai, György; Casanueva, Felipe F.; Maggi, Mario; Forti, Gianni and Alston, Robert D., et al. (2016) In European Journal of Endocrinology 175(6). p.583-593
Abstract

Context: The androgen receptor (AR) gene exon 1 CAG repeat length has been proposed to be a determinant of between-individual variations in androgen action in target tissues, which might regulate phenotypic differences of human ageing. However, findings on its phenotypic effects are inconclusive. Objective: To assess whether the AR CAG repeat length is associated with longitudinal changes in endpoints that are influenced by testosterone (T) levels in middle-Aged and elderly European men. Design: Multinational European observational prospective cohort study. Participants: A total of 1887 men (mean ± s.d. age: 63 ± 11 years; median follow up: 4.3 years) from centres of eight European countries comprised the analysis sample after exclusion... (More)

Context: The androgen receptor (AR) gene exon 1 CAG repeat length has been proposed to be a determinant of between-individual variations in androgen action in target tissues, which might regulate phenotypic differences of human ageing. However, findings on its phenotypic effects are inconclusive. Objective: To assess whether the AR CAG repeat length is associated with longitudinal changes in endpoints that are influenced by testosterone (T) levels in middle-Aged and elderly European men. Design: Multinational European observational prospective cohort study. Participants: A total of 1887 men (mean ± s.d. age: 63 ± 11 years; median follow up: 4.3 years) from centres of eight European countries comprised the analysis sample after exclusion of those with diagnosed diseases of the hypothalamic-pituitary-testicular (HPT) axis. Main outcome measures: Longitudinal associations between the AR CAG repeat and changes in androgen-sensitive endpoints (ASEs) and medical conditions were assessed using regression analysis adjusting for age and centre. The AR CAG repeat length was treated as both a continuous and a categorical (6-20; 21-23; 24-39 repeats) predictor. Additional analysis investigated whether results were independent of baseline T or oestradiol (E2) levels. Results: The AR CAG repeat, when used as a continuous or a categorical predictor, was not associated with longitudinal changes in ASEs or medical conditions after adjustments. These results were independent of T and E2 levels.

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European Journal of Endocrinology
volume
175
issue
6
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11 pages
publisher
Society of the European Journal of Endocrinology
external identifiers
  • scopus:85000838224
  • wos:000386915600015
ISSN
0804-4643
DOI
10.1530/EJE-16-0447
language
English
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yes
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9ed84d39-a171-4364-836e-cb92b67c02b7
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2016-12-19 07:27:52
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2017-11-05 05:11:15
@article{9ed84d39-a171-4364-836e-cb92b67c02b7,
  abstract     = {<p>Context: The androgen receptor (AR) gene exon 1 CAG repeat length has been proposed to be a determinant of between-individual variations in androgen action in target tissues, which might regulate phenotypic differences of human ageing. However, findings on its phenotypic effects are inconclusive. Objective: To assess whether the AR CAG repeat length is associated with longitudinal changes in endpoints that are influenced by testosterone (T) levels in middle-Aged and elderly European men. Design: Multinational European observational prospective cohort study. Participants: A total of 1887 men (mean ± s.d. age: 63 ± 11 years; median follow up: 4.3 years) from centres of eight European countries comprised the analysis sample after exclusion of those with diagnosed diseases of the hypothalamic-pituitary-testicular (HPT) axis. Main outcome measures: Longitudinal associations between the AR CAG repeat and changes in androgen-sensitive endpoints (ASEs) and medical conditions were assessed using regression analysis adjusting for age and centre. The AR CAG repeat length was treated as both a continuous and a categorical (6-20; 21-23; 24-39 repeats) predictor. Additional analysis investigated whether results were independent of baseline T or oestradiol (E2) levels. Results: The AR CAG repeat, when used as a continuous or a categorical predictor, was not associated with longitudinal changes in ASEs or medical conditions after adjustments. These results were independent of T and E<sub>2</sub> levels.</p>},
  author       = {Eendebak, Robert J A H and Huhtaniemi, Ilpo T. and Pye, Stephen R. and Ahern, Tomas and W O'Neill, Terence and Bartfai, György and Casanueva, Felipe F. and Maggi, Mario and Forti, Gianni and Alston, Robert D. and Giwercman, Aleksander and Han, Thang S. and Kula, Krzysztof and Lean, Michael E J and Punab, Margus and Pendleton, Neil and Keevil, Brian G. and Vanderschueren, Dirk and Rutter, Martin K. and Tampubolon, Gindo and Goodacre, Royston and Wu, Frederick C W},
  issn         = {0804-4643},
  language     = {eng},
  month        = {12},
  number       = {6},
  pages        = {583--593},
  publisher    = {Society of the European Journal of Endocrinology},
  series       = {European Journal of Endocrinology},
  title        = {The androgen receptor gene CAG repeat in relation to 4-year changes in androgen-sensitive endpoints in community-dwelling older European men},
  url          = {http://dx.doi.org/10.1530/EJE-16-0447},
  volume       = {175},
  year         = {2016},
}