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Localisation of secretory leucocyte proteinase inhibitor mRNA in nasal mucosa

Westin, Ulla LU ; Fryksmark, Ulla; Polling, Åsa and Ohlsson, Kjell (1994) In Acta Oto-Laryngologica 114(2). p.199-202
Abstract

Human secretory leucocyte proteinase inhibitor (SLPI) is a low-molecular weight, acid-stable inhibitor of polymorphnuclear granulocyte elastase and cathepsin G. Previous reports have demonstrated the existence of SLPI in the respiratory tract, salivary glands and cervical mucosa. Positive staining for SLPI using immunohistochemical techniques has been reported in serous glands in nasal mucosa. We now confirm this observation and show, using in situ hybridization, that the pattern of expression of mRNA corresponds to the distribution of the encoded protein, SLPI. This, together with the high concentration of SLPI in nasal secretions, confirms the hypothesis of a local production of SLPI in the mucous membranes. © 1994 Informa UK Ltd All... (More)

Human secretory leucocyte proteinase inhibitor (SLPI) is a low-molecular weight, acid-stable inhibitor of polymorphnuclear granulocyte elastase and cathepsin G. Previous reports have demonstrated the existence of SLPI in the respiratory tract, salivary glands and cervical mucosa. Positive staining for SLPI using immunohistochemical techniques has been reported in serous glands in nasal mucosa. We now confirm this observation and show, using in situ hybridization, that the pattern of expression of mRNA corresponds to the distribution of the encoded protein, SLPI. This, together with the high concentration of SLPI in nasal secretions, confirms the hypothesis of a local production of SLPI in the mucous membranes. © 1994 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
MRNA, Nasal mucosa, Protease inhibitor, Serous glands, SLPI
in
Acta Oto-Laryngologica
volume
114
issue
2
pages
199 - 202
publisher
Taylor & Francis
external identifiers
  • scopus:0028353950
ISSN
0001-6489
DOI
10.3109/00016489409126042
language
English
LU publication?
yes
id
9ee75d19-cd9e-4b8b-adef-f60238242e2e
date added to LUP
2017-02-13 16:12:22
date last changed
2017-02-13 16:12:22
@article{9ee75d19-cd9e-4b8b-adef-f60238242e2e,
  abstract     = {<p>Human secretory leucocyte proteinase inhibitor (SLPI) is a low-molecular weight, acid-stable inhibitor of polymorphnuclear granulocyte elastase and cathepsin G. Previous reports have demonstrated the existence of SLPI in the respiratory tract, salivary glands and cervical mucosa. Positive staining for SLPI using immunohistochemical techniques has been reported in serous glands in nasal mucosa. We now confirm this observation and show, using in situ hybridization, that the pattern of expression of mRNA corresponds to the distribution of the encoded protein, SLPI. This, together with the high concentration of SLPI in nasal secretions, confirms the hypothesis of a local production of SLPI in the mucous membranes. © 1994 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.</p>},
  author       = {Westin, Ulla and Fryksmark, Ulla and Polling, Åsa and Ohlsson, Kjell},
  issn         = {0001-6489},
  keyword      = {MRNA,Nasal mucosa,Protease inhibitor,Serous glands,SLPI},
  language     = {eng},
  number       = {2},
  pages        = {199--202},
  publisher    = {Taylor & Francis},
  series       = {Acta Oto-Laryngologica},
  title        = {Localisation of secretory leucocyte proteinase inhibitor mRNA in nasal mucosa},
  url          = {http://dx.doi.org/10.3109/00016489409126042},
  volume       = {114},
  year         = {1994},
}