Predictive value of islet cell and insulin autoantibodies for type 1 (insulin-dependent) diabetes mellitus in a population-based study of newly-diagnosed diabetic and matched control children
Landin-Olsson, M LU ; Palmer, J P ; Lernmark, A LU
; Blom, L
LU
; Sundkvist, G
LU
; Nyström, L
and Dahlquist, G
(1992)
In Diabetologia
35(11).
p.73-1068
- Abstract
Most studies evaluating immune markers for prediction of Type 1 (insulin-dependent) diabetes mellitus have focused on first degree relatives, although only 10% of newly-diagnosed patients have an affected first degree relative. The Swedish Childhood Diabetes Register identifies 99% of all diabetic children at diagnosis. In this population-based study, islet cell antibodies and insulin autoantibodies in 0-14-year-old Swedish consecutively-diagnosed patients and control subjects were analysed to define their sensitivity and specificity. Over 16 months (1986-1987), 515 Swedish children developed diabetes. Plasma samples were obtained from 494 (96%) patients, and 420 matched control children. Among patients, the frequency of islet cell... (More)
Most studies evaluating immune markers for prediction of Type 1 (insulin-dependent) diabetes mellitus have focused on first degree relatives, although only 10% of newly-diagnosed patients have an affected first degree relative. The Swedish Childhood Diabetes Register identifies 99% of all diabetic children at diagnosis. In this population-based study, islet cell antibodies and insulin autoantibodies in 0-14-year-old Swedish consecutively-diagnosed patients and control subjects were analysed to define their sensitivity and specificity. Over 16 months (1986-1987), 515 Swedish children developed diabetes. Plasma samples were obtained from 494 (96%) patients, and 420 matched control children. Among patients, the frequency of islet cell antibodies was 84% (415 of 494), insulin autoantibodies 43% (145 of 334); 40% (135 of 334) were positive for both and 88% (294 of 334) were positive for one or both. Among control children, 3% (14 of 420) had islet cell antibodies, 1% (4 of 390) insulin autoantibodies, and 4% (16 of 390) had either autoantibody marker. The predictive value of finding a patient with the disease was only 7% since 4% of the control children were antibody-positive and the cumulative incidence rate up to 15 years of age is 0.38%. None of the autoantibody-positive (n = 21) or negative control children developed diabetes during 3 to 5 years of follow-up. Longitudinal investigations of islet cell or insulin-autoantibody-positive healthy children are necessary to accurately determine the conversion rate from marker positivity to disease onset.
(Less)
- author
- Landin-Olsson, M
LU
; Palmer, J P
; Lernmark, A
LU
; Blom, L
LU
; Sundkvist, G
LU
; Nyström, L
and Dahlquist, G
- organization
- publishing date
- 1992
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Adolescent, Autoantibodies/analysis, Biomarkers/analysis, Child, Child, Preschool, Diabetes Mellitus, Type 1/diagnosis, Follow-Up Studies, Humans, Incidence, Infant, Insulin Antibodies/analysis, Islets of Langerhans/immunology, Longitudinal Studies, Population, Predictive Value of Tests, Sweden/epidemiology
- in
- Diabetologia
- volume
- 35
- issue
- 11
- pages
- 73 - 1068
- publisher
- Springer
- external identifiers
-
- scopus:0026697868
- pmid:1473617
- ISSN
- 0012-186X
- DOI
- 10.1007/BF02221683
- language
- English
- LU publication?
- yes
- id
- 9ef41b7e-6d7b-408c-a814-9c701fb63bf8
- date added to LUP
- 2021-09-21 15:23:49
- date last changed
- 2024-03-13 08:29:42
@article{9ef41b7e-6d7b-408c-a814-9c701fb63bf8,
abstract = {{<p>Most studies evaluating immune markers for prediction of Type 1 (insulin-dependent) diabetes mellitus have focused on first degree relatives, although only 10% of newly-diagnosed patients have an affected first degree relative. The Swedish Childhood Diabetes Register identifies 99% of all diabetic children at diagnosis. In this population-based study, islet cell antibodies and insulin autoantibodies in 0-14-year-old Swedish consecutively-diagnosed patients and control subjects were analysed to define their sensitivity and specificity. Over 16 months (1986-1987), 515 Swedish children developed diabetes. Plasma samples were obtained from 494 (96%) patients, and 420 matched control children. Among patients, the frequency of islet cell antibodies was 84% (415 of 494), insulin autoantibodies 43% (145 of 334); 40% (135 of 334) were positive for both and 88% (294 of 334) were positive for one or both. Among control children, 3% (14 of 420) had islet cell antibodies, 1% (4 of 390) insulin autoantibodies, and 4% (16 of 390) had either autoantibody marker. The predictive value of finding a patient with the disease was only 7% since 4% of the control children were antibody-positive and the cumulative incidence rate up to 15 years of age is 0.38%. None of the autoantibody-positive (n = 21) or negative control children developed diabetes during 3 to 5 years of follow-up. Longitudinal investigations of islet cell or insulin-autoantibody-positive healthy children are necessary to accurately determine the conversion rate from marker positivity to disease onset.</p>}},
author = {{Landin-Olsson, M and Palmer, J P and Lernmark, A and Blom, L and Sundkvist, G and Nyström, L and Dahlquist, G}},
issn = {{0012-186X}},
keywords = {{Adolescent; Autoantibodies/analysis; Biomarkers/analysis; Child; Child, Preschool; Diabetes Mellitus, Type 1/diagnosis; Follow-Up Studies; Humans; Incidence; Infant; Insulin Antibodies/analysis; Islets of Langerhans/immunology; Longitudinal Studies; Population; Predictive Value of Tests; Sweden/epidemiology}},
language = {{eng}},
number = {{11}},
pages = {{73--1068}},
publisher = {{Springer}},
series = {{Diabetologia}},
title = {{Predictive value of islet cell and insulin autoantibodies for type 1 (insulin-dependent) diabetes mellitus in a population-based study of newly-diagnosed diabetic and matched control children}},
url = {{http://dx.doi.org/10.1007/BF02221683}},
doi = {{10.1007/BF02221683}},
volume = {{35}},
year = {{1992}},
}