Predictive value of islet cell and insulin autoantibodies for type 1 (insulin-dependent) diabetes mellitus in a population-based study of newly-diagnosed diabetic and matched control children
(1992) In Diabetologia 35(11). p.73-1068- Abstract
Most studies evaluating immune markers for prediction of Type 1 (insulin-dependent) diabetes mellitus have focused on first degree relatives, although only 10% of newly-diagnosed patients have an affected first degree relative. The Swedish Childhood Diabetes Register identifies 99% of all diabetic children at diagnosis. In this population-based study, islet cell antibodies and insulin autoantibodies in 0-14-year-old Swedish consecutively-diagnosed patients and control subjects were analysed to define their sensitivity and specificity. Over 16 months (1986-1987), 515 Swedish children developed diabetes. Plasma samples were obtained from 494 (96%) patients, and 420 matched control children. Among patients, the frequency of islet cell... (More)
Most studies evaluating immune markers for prediction of Type 1 (insulin-dependent) diabetes mellitus have focused on first degree relatives, although only 10% of newly-diagnosed patients have an affected first degree relative. The Swedish Childhood Diabetes Register identifies 99% of all diabetic children at diagnosis. In this population-based study, islet cell antibodies and insulin autoantibodies in 0-14-year-old Swedish consecutively-diagnosed patients and control subjects were analysed to define their sensitivity and specificity. Over 16 months (1986-1987), 515 Swedish children developed diabetes. Plasma samples were obtained from 494 (96%) patients, and 420 matched control children. Among patients, the frequency of islet cell antibodies was 84% (415 of 494), insulin autoantibodies 43% (145 of 334); 40% (135 of 334) were positive for both and 88% (294 of 334) were positive for one or both. Among control children, 3% (14 of 420) had islet cell antibodies, 1% (4 of 390) insulin autoantibodies, and 4% (16 of 390) had either autoantibody marker. The predictive value of finding a patient with the disease was only 7% since 4% of the control children were antibody-positive and the cumulative incidence rate up to 15 years of age is 0.38%. None of the autoantibody-positive (n = 21) or negative control children developed diabetes during 3 to 5 years of follow-up. Longitudinal investigations of islet cell or insulin-autoantibody-positive healthy children are necessary to accurately determine the conversion rate from marker positivity to disease onset.
(Less)
- author
- Landin-Olsson, M LU ; Palmer, J P ; Lernmark, A LU ; Blom, L LU ; Sundkvist, G LU ; Nyström, L and Dahlquist, G
- organization
- publishing date
- 1992
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Adolescent, Autoantibodies/analysis, Biomarkers/analysis, Child, Child, Preschool, Diabetes Mellitus, Type 1/diagnosis, Follow-Up Studies, Humans, Incidence, Infant, Insulin Antibodies/analysis, Islets of Langerhans/immunology, Longitudinal Studies, Population, Predictive Value of Tests, Sweden/epidemiology
- in
- Diabetologia
- volume
- 35
- issue
- 11
- pages
- 73 - 1068
- publisher
- Springer
- external identifiers
-
- pmid:1473617
- scopus:0026697868
- ISSN
- 0012-186X
- DOI
- 10.1007/BF02221683
- language
- English
- LU publication?
- yes
- id
- 9ef41b7e-6d7b-408c-a814-9c701fb63bf8
- date added to LUP
- 2021-09-21 15:23:49
- date last changed
- 2024-03-13 08:29:42
@article{9ef41b7e-6d7b-408c-a814-9c701fb63bf8, abstract = {{<p>Most studies evaluating immune markers for prediction of Type 1 (insulin-dependent) diabetes mellitus have focused on first degree relatives, although only 10% of newly-diagnosed patients have an affected first degree relative. The Swedish Childhood Diabetes Register identifies 99% of all diabetic children at diagnosis. In this population-based study, islet cell antibodies and insulin autoantibodies in 0-14-year-old Swedish consecutively-diagnosed patients and control subjects were analysed to define their sensitivity and specificity. Over 16 months (1986-1987), 515 Swedish children developed diabetes. Plasma samples were obtained from 494 (96%) patients, and 420 matched control children. Among patients, the frequency of islet cell antibodies was 84% (415 of 494), insulin autoantibodies 43% (145 of 334); 40% (135 of 334) were positive for both and 88% (294 of 334) were positive for one or both. Among control children, 3% (14 of 420) had islet cell antibodies, 1% (4 of 390) insulin autoantibodies, and 4% (16 of 390) had either autoantibody marker. The predictive value of finding a patient with the disease was only 7% since 4% of the control children were antibody-positive and the cumulative incidence rate up to 15 years of age is 0.38%. None of the autoantibody-positive (n = 21) or negative control children developed diabetes during 3 to 5 years of follow-up. Longitudinal investigations of islet cell or insulin-autoantibody-positive healthy children are necessary to accurately determine the conversion rate from marker positivity to disease onset.</p>}}, author = {{Landin-Olsson, M and Palmer, J P and Lernmark, A and Blom, L and Sundkvist, G and Nyström, L and Dahlquist, G}}, issn = {{0012-186X}}, keywords = {{Adolescent; Autoantibodies/analysis; Biomarkers/analysis; Child; Child, Preschool; Diabetes Mellitus, Type 1/diagnosis; Follow-Up Studies; Humans; Incidence; Infant; Insulin Antibodies/analysis; Islets of Langerhans/immunology; Longitudinal Studies; Population; Predictive Value of Tests; Sweden/epidemiology}}, language = {{eng}}, number = {{11}}, pages = {{73--1068}}, publisher = {{Springer}}, series = {{Diabetologia}}, title = {{Predictive value of islet cell and insulin autoantibodies for type 1 (insulin-dependent) diabetes mellitus in a population-based study of newly-diagnosed diabetic and matched control children}}, url = {{http://dx.doi.org/10.1007/BF02221683}}, doi = {{10.1007/BF02221683}}, volume = {{35}}, year = {{1992}}, }