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Thymic-derived tolerizing dendritic cells are upregulated in the spleen upon treatment with intravenous immunoglobulin in a murine model of immune thrombocytopenia AU - Kapur, Rick

Aslam, Rukhsana ; Kim, Michael ; Guo, Li ; Ni, Heyu ; Segel, George B. and Semple, John W. LU (2017) In Platelets 28(5). p.521-524
Abstract
AbstractImmune thrombocytopenia (ITP) is an autoimmune bleeding disorder characterized by low platelet counts. First-line treatment includes intravenous immunoglobulin (IVIg), however, its working mechanism remains incompletely understood. We investigated splenic and thymic dendritic cell (DC) subsets upon IVIg treatment in a well-characterized active murine model of ITP. During active disease, there was a significant peripheral deficiency of splenic tolerizing SIRPα+ DCs which could be rescued by IVIg therapy, increasing platelet counts. These splenic tolerizing DC changes were associated with an abrogation of the thymic-retention of tolerizing DCs, suggesting that IVIg may raise platelet counts in ITP by modulating peripheral numbers of... (More)
AbstractImmune thrombocytopenia (ITP) is an autoimmune bleeding disorder characterized by low platelet counts. First-line treatment includes intravenous immunoglobulin (IVIg), however, its working mechanism remains incompletely understood. We investigated splenic and thymic dendritic cell (DC) subsets upon IVIg treatment in a well-characterized active murine model of ITP. During active disease, there was a significant peripheral deficiency of splenic tolerizing SIRPα+ DCs which could be rescued by IVIg therapy, increasing platelet counts. These splenic tolerizing DC changes were associated with an abrogation of the thymic-retention of tolerizing DCs, suggesting that IVIg may raise platelet counts in ITP by modulating peripheral numbers of tolerizing DCs. (Less)
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author
publishing date
type
Contribution to journal
publication status
published
in
Platelets
volume
28
issue
5
pages
521 - 524
publisher
Taylor & Francis
external identifiers
  • scopus:84997241493
ISSN
0953-7104
DOI
10.1080/09537104.2016.1246718
language
English
LU publication?
no
additional info
doi: 10.1080/09537104.2016.1246718
id
9ef886fb-4e90-45af-ac05-96636e877808
date added to LUP
2019-02-08 10:52:57
date last changed
2020-02-12 09:53:19
@article{9ef886fb-4e90-45af-ac05-96636e877808,
  abstract     = {AbstractImmune thrombocytopenia (ITP) is an autoimmune bleeding disorder characterized by low platelet counts. First-line treatment includes intravenous immunoglobulin (IVIg), however, its working mechanism remains incompletely understood. We investigated splenic and thymic dendritic cell (DC) subsets upon IVIg treatment in a well-characterized active murine model of ITP. During active disease, there was a significant peripheral deficiency of splenic tolerizing SIRPα+ DCs which could be rescued by IVIg therapy, increasing platelet counts. These splenic tolerizing DC changes were associated with an abrogation of the thymic-retention of tolerizing DCs, suggesting that IVIg may raise platelet counts in ITP by modulating peripheral numbers of tolerizing DCs.},
  author       = {Aslam, Rukhsana and Kim, Michael and Guo, Li and Ni, Heyu and Segel, George B. and Semple, John W.},
  issn         = {0953-7104},
  language     = {eng},
  month        = {07},
  number       = {5},
  pages        = {521--524},
  publisher    = {Taylor & Francis},
  series       = {Platelets},
  title        = {Thymic-derived tolerizing dendritic cells are upregulated in the spleen upon treatment with intravenous immunoglobulin in a murine model of immune thrombocytopenia AU  - Kapur, Rick},
  url          = {http://dx.doi.org/10.1080/09537104.2016.1246718},
  doi          = {10.1080/09537104.2016.1246718},
  volume       = {28},
  year         = {2017},
}