Thymic-derived tolerizing dendritic cells are upregulated in the spleen upon treatment with intravenous immunoglobulin in a murine model of immune thrombocytopenia AU - Kapur, Rick
(2017) In Platelets 28(5). p.521-524- Abstract
- AbstractImmune thrombocytopenia (ITP) is an autoimmune bleeding disorder characterized by low platelet counts. First-line treatment includes intravenous immunoglobulin (IVIg), however, its working mechanism remains incompletely understood. We investigated splenic and thymic dendritic cell (DC) subsets upon IVIg treatment in a well-characterized active murine model of ITP. During active disease, there was a significant peripheral deficiency of splenic tolerizing SIRPα+ DCs which could be rescued by IVIg therapy, increasing platelet counts. These splenic tolerizing DC changes were associated with an abrogation of the thymic-retention of tolerizing DCs, suggesting that IVIg may raise platelet counts in ITP by modulating peripheral numbers of... (More)
- AbstractImmune thrombocytopenia (ITP) is an autoimmune bleeding disorder characterized by low platelet counts. First-line treatment includes intravenous immunoglobulin (IVIg), however, its working mechanism remains incompletely understood. We investigated splenic and thymic dendritic cell (DC) subsets upon IVIg treatment in a well-characterized active murine model of ITP. During active disease, there was a significant peripheral deficiency of splenic tolerizing SIRPα+ DCs which could be rescued by IVIg therapy, increasing platelet counts. These splenic tolerizing DC changes were associated with an abrogation of the thymic-retention of tolerizing DCs, suggesting that IVIg may raise platelet counts in ITP by modulating peripheral numbers of tolerizing DCs. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/9ef886fb-4e90-45af-ac05-96636e877808
- author
- Aslam, Rukhsana ; Kim, Michael ; Guo, Li ; Ni, Heyu ; Segel, George B. and Semple, John W. LU
- publishing date
- 2017-07-04
- type
- Contribution to journal
- publication status
- published
- in
- Platelets
- volume
- 28
- issue
- 5
- pages
- 521 - 524
- publisher
- Taylor & Francis
- external identifiers
-
- scopus:84997241493
- ISSN
- 0953-7104
- DOI
- 10.1080/09537104.2016.1246718
- language
- English
- LU publication?
- no
- additional info
- doi: 10.1080/09537104.2016.1246718
- id
- 9ef886fb-4e90-45af-ac05-96636e877808
- date added to LUP
- 2019-02-08 10:52:57
- date last changed
- 2022-04-25 21:26:28
@article{9ef886fb-4e90-45af-ac05-96636e877808,
abstract = {{AbstractImmune thrombocytopenia (ITP) is an autoimmune bleeding disorder characterized by low platelet counts. First-line treatment includes intravenous immunoglobulin (IVIg), however, its working mechanism remains incompletely understood. We investigated splenic and thymic dendritic cell (DC) subsets upon IVIg treatment in a well-characterized active murine model of ITP. During active disease, there was a significant peripheral deficiency of splenic tolerizing SIRPα+ DCs which could be rescued by IVIg therapy, increasing platelet counts. These splenic tolerizing DC changes were associated with an abrogation of the thymic-retention of tolerizing DCs, suggesting that IVIg may raise platelet counts in ITP by modulating peripheral numbers of tolerizing DCs.}},
author = {{Aslam, Rukhsana and Kim, Michael and Guo, Li and Ni, Heyu and Segel, George B. and Semple, John W.}},
issn = {{0953-7104}},
language = {{eng}},
month = {{07}},
number = {{5}},
pages = {{521--524}},
publisher = {{Taylor & Francis}},
series = {{Platelets}},
title = {{Thymic-derived tolerizing dendritic cells are upregulated in the spleen upon treatment with intravenous immunoglobulin in a murine model of immune thrombocytopenia AU - Kapur, Rick}},
url = {{http://dx.doi.org/10.1080/09537104.2016.1246718}},
doi = {{10.1080/09537104.2016.1246718}},
volume = {{28}},
year = {{2017}},
}