chinmo-mutant spermatogonial stem cells cause mitotic drive by evicting non-mutant neighbors from the niche
Tseng, Chen-Yuan ; Burel, Michael ; Cammer, Michael ; Harsh, Sneh ; Flaherty, Maria Sol ; Baumgartner, Stefan LU
and Bach, Erika A
(2022)
In Developmental Cell
57(1).
p.7-94
- Abstract
Niches maintain a finite pool of stem cells via restricted space and short-range signals. Stem cells compete for limited niche resources, but the mechanisms regulating competition are poorly understood. Using the Drosophila testis model, we show that germline stem cells (GSCs) lacking the transcription factor Chinmo gain a competitive advantage for niche access. Surprisingly, chinmo-/- GSCs rely on a new mechanism of competition in which they secrete the extracellular matrix protein Perlecan to selectively evict non-mutant GSCs and then upregulate Perlecan-binding proteins to remain in the altered niche. Over time, the GSC pool can be entirely replaced with chinmo-/- cells. As a consequence, the mutant chinmo allele acts as a gene drive... (More)
Niches maintain a finite pool of stem cells via restricted space and short-range signals. Stem cells compete for limited niche resources, but the mechanisms regulating competition are poorly understood. Using the Drosophila testis model, we show that germline stem cells (GSCs) lacking the transcription factor Chinmo gain a competitive advantage for niche access. Surprisingly, chinmo-/- GSCs rely on a new mechanism of competition in which they secrete the extracellular matrix protein Perlecan to selectively evict non-mutant GSCs and then upregulate Perlecan-binding proteins to remain in the altered niche. Over time, the GSC pool can be entirely replaced with chinmo-/- cells. As a consequence, the mutant chinmo allele acts as a gene drive element; the majority of offspring inherit the allele despite the heterozygous genotype of the parent. Our results suggest that the influence of GSC competition may extend beyond individual stem cell niche dynamics to population-level allelic drift and evolution.
(Less)
- author
- Tseng, Chen-Yuan
; Burel, Michael
; Cammer, Michael
; Harsh, Sneh
; Flaherty, Maria Sol
; Baumgartner, Stefan
LU
and Bach, Erika A
- organization
- publishing date
- 2022-01-10
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Developmental Cell
- volume
- 57
- issue
- 1
- pages
- 7 - 94
- publisher
- Cell Press
- external identifiers
-
- pmid:34942115
- scopus:85123245425
- ISSN
- 1534-5807
- DOI
- 10.1016/j.devcel.2021.12.004
- language
- English
- LU publication?
- yes
- additional info
- Copyright © 2021 Elsevier Inc. All rights reserved.
- id
- 9f09517a-e5dd-4590-8af1-4cd14245a32a
- date added to LUP
- 2022-02-03 11:25:18
- date last changed
- 2024-04-10 05:12:00
@article{9f09517a-e5dd-4590-8af1-4cd14245a32a,
abstract = {{<p>Niches maintain a finite pool of stem cells via restricted space and short-range signals. Stem cells compete for limited niche resources, but the mechanisms regulating competition are poorly understood. Using the Drosophila testis model, we show that germline stem cells (GSCs) lacking the transcription factor Chinmo gain a competitive advantage for niche access. Surprisingly, chinmo-/- GSCs rely on a new mechanism of competition in which they secrete the extracellular matrix protein Perlecan to selectively evict non-mutant GSCs and then upregulate Perlecan-binding proteins to remain in the altered niche. Over time, the GSC pool can be entirely replaced with chinmo-/- cells. As a consequence, the mutant chinmo allele acts as a gene drive element; the majority of offspring inherit the allele despite the heterozygous genotype of the parent. Our results suggest that the influence of GSC competition may extend beyond individual stem cell niche dynamics to population-level allelic drift and evolution.</p>}},
author = {{Tseng, Chen-Yuan and Burel, Michael and Cammer, Michael and Harsh, Sneh and Flaherty, Maria Sol and Baumgartner, Stefan and Bach, Erika A}},
issn = {{1534-5807}},
language = {{eng}},
month = {{01}},
number = {{1}},
pages = {{7--94}},
publisher = {{Cell Press}},
series = {{Developmental Cell}},
title = {{<i>chinmo</i>-mutant spermatogonial stem cells cause mitotic drive by evicting non-mutant neighbors from the niche}},
url = {{http://dx.doi.org/10.1016/j.devcel.2021.12.004}},
doi = {{10.1016/j.devcel.2021.12.004}},
volume = {{57}},
year = {{2022}},
}