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Dynamic Guiding of Motor-Driven Microtubules on Electrically Heated, Smart Polymer Tracks

Schroeder, Viktor ; Korten, Till ; Linke, Heiner ; Diez, Stefan and Maximov, Ivan LU (2013) In Nano Letters 13(7). p.3434-3438
Abstract
Biomolecular motor systems are attractive for future nanotechnological devices because they can replace nanofluidics by directed transport. However, the lack of methods to externally control motor-driven transport along complex paths limits their range of applications. Based on a thermo-responsive polymer, we developed a novel technique to guide microtubules propelled by kinesin-1 motors on a planar surface. Using electrically heated gold microstructures, the polymers were locally collapsed, creating dynamically switchable tracks that successfully guided microtubule movement.
Please use this url to cite or link to this publication:
author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Microtubule, kinesin, poly(N-isopropylacrylamide) (PNIPAM), directional, guiding, Y-junction
in
Nano Letters
volume
13
issue
7
pages
3434 - 3438
publisher
The American Chemical Society (ACS)
external identifiers
  • wos:000321884300070
  • scopus:84880156150
  • pmid:23750886
ISSN
1530-6992
DOI
10.1021/nl402004s
language
English
LU publication?
yes
id
9f1379ef-90d1-430a-b153-7e10d4fd4a9c (old id 3974081)
date added to LUP
2016-04-01 13:05:37
date last changed
2023-10-14 21:54:17
@article{9f1379ef-90d1-430a-b153-7e10d4fd4a9c,
  abstract     = {{Biomolecular motor systems are attractive for future nanotechnological devices because they can replace nanofluidics by directed transport. However, the lack of methods to externally control motor-driven transport along complex paths limits their range of applications. Based on a thermo-responsive polymer, we developed a novel technique to guide microtubules propelled by kinesin-1 motors on a planar surface. Using electrically heated gold microstructures, the polymers were locally collapsed, creating dynamically switchable tracks that successfully guided microtubule movement.}},
  author       = {{Schroeder, Viktor and Korten, Till and Linke, Heiner and Diez, Stefan and Maximov, Ivan}},
  issn         = {{1530-6992}},
  keywords     = {{Microtubule; kinesin; poly(N-isopropylacrylamide) (PNIPAM); directional; guiding; Y-junction}},
  language     = {{eng}},
  number       = {{7}},
  pages        = {{3434--3438}},
  publisher    = {{The American Chemical Society (ACS)}},
  series       = {{Nano Letters}},
  title        = {{Dynamic Guiding of Motor-Driven Microtubules on Electrically Heated, Smart Polymer Tracks}},
  url          = {{http://dx.doi.org/10.1021/nl402004s}},
  doi          = {{10.1021/nl402004s}},
  volume       = {{13}},
  year         = {{2013}},
}