18F-FDG PET/CT for planning external beam radiotherapy alters therapy in 11% of 581 patients
Birk Christensen, Charlotte ; Loft-Jakobsen, Annika ; Munck af Rosenschöld, Per LU
; Højgaard, Liselotte
; Roed, Henrik
and Berthelsen, Anne K.
(2018)
In Clinical Physiology and Functional Imaging
38(2).
p.278-284
- Abstract
Background: 18F-FDG PET/CT (FDG PET/CT) used in radiotherapy planning for extra-cerebral malignancy may reveal metastases to distant sites that may affect the choice of therapy. Aim: To investigate the role of FDG PET/CT on treatment strategy changes induced by the use of PET/CT as part of the radiotherapy planning. ‘A major change of treatment strategy’ was defined as either including more lesions in the gross tumour volume (GTV) distant from the primary tumour or a change in treatment modalities. Methods: The study includes 581 consecutive patients who underwent an FDG PET/CT scan for radiotherapy planning in our institution in the year 2008. All PET/CT scans were performed with the patient in treatment position with the... (More)
Background: 18F-FDG PET/CT (FDG PET/CT) used in radiotherapy planning for extra-cerebral malignancy may reveal metastases to distant sites that may affect the choice of therapy. Aim: To investigate the role of FDG PET/CT on treatment strategy changes induced by the use of PET/CT as part of the radiotherapy planning. ‘A major change of treatment strategy’ was defined as either including more lesions in the gross tumour volume (GTV) distant from the primary tumour or a change in treatment modalities. Methods: The study includes 581 consecutive patients who underwent an FDG PET/CT scan for radiotherapy planning in our institution in the year 2008. All PET/CT scans were performed with the patient in treatment position with the use of immobilization devices according to the intended radiotherapy treatment. All scans were evaluated by a nuclear medicine physician together with a radiologist to delineate PET-positive GTV (GTV-PET). Results: For 63 of the patients (11%), the PET/CT simulation scans resulted in a major change in treatment strategy because of the additional diagnostic information. Changes were most frequently observed in patients with lung cancer (20%) or upper gastrointestinal cancer (12%). In 65% of the patients for whom the PET/CT simulation scan revealed unexpected dissemination, radiotherapy was given – changed (n = 38) or unchanged (n = 13) according to the findings on the FDG PET/CT. Conclusion: Unexpected dissemination on the FDG PET/CT scanning performed for radiotherapy planning caused a change in treatment strategy in 11% of 581 patients.
(Less)
- author
- Birk Christensen, Charlotte
; Loft-Jakobsen, Annika
; Munck af Rosenschöld, Per
LU
; Højgaard, Liselotte
; Roed, Henrik
and Berthelsen, Anne K.
- publishing date
- 2018-03-01
- type
- Contribution to journal
- publication status
- published
- keywords
- PET-gross tumour volume, positron emission tomography, simulation scan, solid tumours, treatment planning
- in
- Clinical Physiology and Functional Imaging
- volume
- 38
- issue
- 2
- pages
- 7 pages
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- scopus:85012067051
- pmid:28168798
- ISSN
- 1475-0961
- DOI
- 10.1111/cpf.12411
- language
- English
- LU publication?
- no
- id
- 9f738f42-85d7-4aca-8384-4f47b331a6b8
- date added to LUP
- 2020-07-28 08:58:42
- date last changed
- 2024-05-01 15:24:29
@article{9f738f42-85d7-4aca-8384-4f47b331a6b8,
abstract = {{<p>Background: <sup>18</sup>F-FDG PET/CT (FDG PET/CT) used in radiotherapy planning for extra-cerebral malignancy may reveal metastases to distant sites that may affect the choice of therapy. Aim: To investigate the role of FDG PET/CT on treatment strategy changes induced by the use of PET/CT as part of the radiotherapy planning. ‘A major change of treatment strategy’ was defined as either including more lesions in the gross tumour volume (GTV) distant from the primary tumour or a change in treatment modalities. Methods: The study includes 581 consecutive patients who underwent an FDG PET/CT scan for radiotherapy planning in our institution in the year 2008. All PET/CT scans were performed with the patient in treatment position with the use of immobilization devices according to the intended radiotherapy treatment. All scans were evaluated by a nuclear medicine physician together with a radiologist to delineate PET-positive GTV (GTV-PET). Results: For 63 of the patients (11%), the PET/CT simulation scans resulted in a major change in treatment strategy because of the additional diagnostic information. Changes were most frequently observed in patients with lung cancer (20%) or upper gastrointestinal cancer (12%). In 65% of the patients for whom the PET/CT simulation scan revealed unexpected dissemination, radiotherapy was given – changed (n = 38) or unchanged (n = 13) according to the findings on the FDG PET/CT. Conclusion: Unexpected dissemination on the FDG PET/CT scanning performed for radiotherapy planning caused a change in treatment strategy in 11% of 581 patients.</p>}},
author = {{Birk Christensen, Charlotte and Loft-Jakobsen, Annika and Munck af Rosenschöld, Per and Højgaard, Liselotte and Roed, Henrik and Berthelsen, Anne K.}},
issn = {{1475-0961}},
keywords = {{PET-gross tumour volume; positron emission tomography; simulation scan; solid tumours; treatment planning}},
language = {{eng}},
month = {{03}},
number = {{2}},
pages = {{278--284}},
publisher = {{John Wiley & Sons Inc.}},
series = {{Clinical Physiology and Functional Imaging}},
title = {{<sup>18</sup>F-FDG PET/CT for planning external beam radiotherapy alters therapy in 11% of 581 patients}},
url = {{http://dx.doi.org/10.1111/cpf.12411}},
doi = {{10.1111/cpf.12411}},
volume = {{38}},
year = {{2018}},
}