Validation of a Parent-Reported Diagnostic Instrument in a U.S. Referral Population : The Childhood Eczema Questionnaire
(2017) In Pediatric Dermatology 34(4). p.398-401- Abstract
Background/Objectives: There is a paucity of validated tools for diagnosing atopic dermatitis (AD) in very young children that do not rely on clinical evaluation. The Childhood Eczema Questionnaire (CEQ)-a diagnostic tool for AD in children younger than 2 years that a caretaker can complete-was recently validated in Sweden. The objective of this study was to validate the tool in a U.S. population. As a substudy, we added an additional question that was independently assessed. Methods: Children younger than 2 years old were recruited from a dermatology clinic. Their caretakers completed a questionnaire containing the original tool's three questions as well as a fourth question that increased the time frame measured from 1 week to 6... (More)
Background/Objectives: There is a paucity of validated tools for diagnosing atopic dermatitis (AD) in very young children that do not rely on clinical evaluation. The Childhood Eczema Questionnaire (CEQ)-a diagnostic tool for AD in children younger than 2 years that a caretaker can complete-was recently validated in Sweden. The objective of this study was to validate the tool in a U.S. population. As a substudy, we added an additional question that was independently assessed. Methods: Children younger than 2 years old were recruited from a dermatology clinic. Their caretakers completed a questionnaire containing the original tool's three questions as well as a fourth question that increased the time frame measured from 1 week to 6 months. Questionnaires with all "yes" answers were considered positive and were compared with a dermatologist diagnosis of AD. Results: A total of 283 subjects were recruited. The first three questions (the original CEQ) predicted a positive diagnosis of AD with a sensitivity of 0.72 (95% confidence interval [CI] 0.58, 0.82) and a specificity of 0.93 (95% CI 0.87, 0.95). In a separate analysis we included the first two questions and the fourth question and found that the sensitivity increased to 0.82 (95% CI 0.69, 0.90) with a specificity of 0.89 (95% CI 0.83, 0.93). Conclusion: This study validates a novel parental questionnaire for the diagnosis of AD in children younger than 2 years in a U.S. clinic population.
(Less)
- author
- Leitenberger, Sabra ; Hajar, Tamar ; Simpson, Eric L. ; von Kobyletzki, Laura LU and Hanifin, Jon M.
- organization
- publishing date
- 2017-05-19
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Pediatric Dermatology
- volume
- 34
- issue
- 4
- pages
- 398 - 401
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:28523849
- wos:000405121100026
- scopus:85019372451
- ISSN
- 0736-8046
- DOI
- 10.1111/pde.13139
- language
- English
- LU publication?
- yes
- id
- 9fcfa35b-08e7-4b7e-97b1-ed5e4cdf03d4
- date added to LUP
- 2017-06-15 10:04:59
- date last changed
- 2024-02-29 16:44:27
@article{9fcfa35b-08e7-4b7e-97b1-ed5e4cdf03d4,
abstract = {{<p>Background/Objectives: There is a paucity of validated tools for diagnosing atopic dermatitis (AD) in very young children that do not rely on clinical evaluation. The Childhood Eczema Questionnaire (CEQ)-a diagnostic tool for AD in children younger than 2 years that a caretaker can complete-was recently validated in Sweden. The objective of this study was to validate the tool in a U.S. population. As a substudy, we added an additional question that was independently assessed. Methods: Children younger than 2 years old were recruited from a dermatology clinic. Their caretakers completed a questionnaire containing the original tool's three questions as well as a fourth question that increased the time frame measured from 1 week to 6 months. Questionnaires with all "yes" answers were considered positive and were compared with a dermatologist diagnosis of AD. Results: A total of 283 subjects were recruited. The first three questions (the original CEQ) predicted a positive diagnosis of AD with a sensitivity of 0.72 (95% confidence interval [CI] 0.58, 0.82) and a specificity of 0.93 (95% CI 0.87, 0.95). In a separate analysis we included the first two questions and the fourth question and found that the sensitivity increased to 0.82 (95% CI 0.69, 0.90) with a specificity of 0.89 (95% CI 0.83, 0.93). Conclusion: This study validates a novel parental questionnaire for the diagnosis of AD in children younger than 2 years in a U.S. clinic population.</p>}},
author = {{Leitenberger, Sabra and Hajar, Tamar and Simpson, Eric L. and von Kobyletzki, Laura and Hanifin, Jon M.}},
issn = {{0736-8046}},
language = {{eng}},
month = {{05}},
number = {{4}},
pages = {{398--401}},
publisher = {{Wiley-Blackwell}},
series = {{Pediatric Dermatology}},
title = {{Validation of a Parent-Reported Diagnostic Instrument in a U.S. Referral Population : The Childhood Eczema Questionnaire}},
url = {{http://dx.doi.org/10.1111/pde.13139}},
doi = {{10.1111/pde.13139}},
volume = {{34}},
year = {{2017}},
}