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Validation of a Parent-Reported Diagnostic Instrument in a U.S. Referral Population : The Childhood Eczema Questionnaire

Leitenberger, Sabra ; Hajar, Tamar ; Simpson, Eric L. ; von Kobyletzki, Laura LU and Hanifin, Jon M. (2017) In Pediatric Dermatology 34(4). p.398-401
Abstract

Background/Objectives: There is a paucity of validated tools for diagnosing atopic dermatitis (AD) in very young children that do not rely on clinical evaluation. The Childhood Eczema Questionnaire (CEQ)-a diagnostic tool for AD in children younger than 2 years that a caretaker can complete-was recently validated in Sweden. The objective of this study was to validate the tool in a U.S. population. As a substudy, we added an additional question that was independently assessed. Methods: Children younger than 2 years old were recruited from a dermatology clinic. Their caretakers completed a questionnaire containing the original tool's three questions as well as a fourth question that increased the time frame measured from 1 week to 6... (More)

Background/Objectives: There is a paucity of validated tools for diagnosing atopic dermatitis (AD) in very young children that do not rely on clinical evaluation. The Childhood Eczema Questionnaire (CEQ)-a diagnostic tool for AD in children younger than 2 years that a caretaker can complete-was recently validated in Sweden. The objective of this study was to validate the tool in a U.S. population. As a substudy, we added an additional question that was independently assessed. Methods: Children younger than 2 years old were recruited from a dermatology clinic. Their caretakers completed a questionnaire containing the original tool's three questions as well as a fourth question that increased the time frame measured from 1 week to 6 months. Questionnaires with all "yes" answers were considered positive and were compared with a dermatologist diagnosis of AD. Results: A total of 283 subjects were recruited. The first three questions (the original CEQ) predicted a positive diagnosis of AD with a sensitivity of 0.72 (95% confidence interval [CI] 0.58, 0.82) and a specificity of 0.93 (95% CI 0.87, 0.95). In a separate analysis we included the first two questions and the fourth question and found that the sensitivity increased to 0.82 (95% CI 0.69, 0.90) with a specificity of 0.89 (95% CI 0.83, 0.93). Conclusion: This study validates a novel parental questionnaire for the diagnosis of AD in children younger than 2 years in a U.S. clinic population.

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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Pediatric Dermatology
volume
34
issue
4
pages
398 - 401
publisher
John Wiley & Sons Inc.
external identifiers
  • pmid:28523849
  • wos:000405121100026
  • scopus:85019372451
ISSN
0736-8046
DOI
10.1111/pde.13139
language
English
LU publication?
yes
id
9fcfa35b-08e7-4b7e-97b1-ed5e4cdf03d4
date added to LUP
2017-06-15 10:04:59
date last changed
2025-01-07 15:27:17
@article{9fcfa35b-08e7-4b7e-97b1-ed5e4cdf03d4,
  abstract     = {{<p>Background/Objectives: There is a paucity of validated tools for diagnosing atopic dermatitis (AD) in very young children that do not rely on clinical evaluation. The Childhood Eczema Questionnaire (CEQ)-a diagnostic tool for AD in children younger than 2 years that a caretaker can complete-was recently validated in Sweden. The objective of this study was to validate the tool in a U.S. population. As a substudy, we added an additional question that was independently assessed. Methods: Children younger than 2 years old were recruited from a dermatology clinic. Their caretakers completed a questionnaire containing the original tool's three questions as well as a fourth question that increased the time frame measured from 1 week to 6 months. Questionnaires with all "yes" answers were considered positive and were compared with a dermatologist diagnosis of AD. Results: A total of 283 subjects were recruited. The first three questions (the original CEQ) predicted a positive diagnosis of AD with a sensitivity of 0.72 (95% confidence interval [CI] 0.58, 0.82) and a specificity of 0.93 (95% CI 0.87, 0.95). In a separate analysis we included the first two questions and the fourth question and found that the sensitivity increased to 0.82 (95% CI 0.69, 0.90) with a specificity of 0.89 (95% CI 0.83, 0.93). Conclusion: This study validates a novel parental questionnaire for the diagnosis of AD in children younger than 2 years in a U.S. clinic population.</p>}},
  author       = {{Leitenberger, Sabra and Hajar, Tamar and Simpson, Eric L. and von Kobyletzki, Laura and Hanifin, Jon M.}},
  issn         = {{0736-8046}},
  language     = {{eng}},
  month        = {{05}},
  number       = {{4}},
  pages        = {{398--401}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{Pediatric Dermatology}},
  title        = {{Validation of a Parent-Reported Diagnostic Instrument in a U.S. Referral Population : The Childhood Eczema Questionnaire}},
  url          = {{http://dx.doi.org/10.1111/pde.13139}},
  doi          = {{10.1111/pde.13139}},
  volume       = {{34}},
  year         = {{2017}},
}