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100 million years of multigene family evolution : Origin and evolution of the avian MHC class IIB

Goebel, Julien; Promerová, Marta; Bonadonna, Francesco; McCoy, Karen D.; Serbielle, Céline; Strandh, Maria LU ; Yannic, Glenn; Burri, Reto and Fumagalli, Luca (2017) In BMC Genomics 18(1).
Abstract

Background: Gene duplication has led to a most remarkable adaptation involved in vertebrates' host-pathogen arms-race, the major histocompatibility complex (MHC). However, MHC duplication history is as yet poorly understood in non-mammalian vertebrates, including birds. Results: Here, we provide evidence for the evolution of two ancient avian MHC class IIB (MHCIIB) lineages by a duplication event prior to the radiation of all extant birds >100 million years ago, and document the role of concerted evolution in eroding the footprints of the avian MHCIIB duplication history. Conclusions: Our results suggest that eroded footprints of gene duplication histories may mimic birth-death evolution and that in the avian MHC the presence of the... (More)

Background: Gene duplication has led to a most remarkable adaptation involved in vertebrates' host-pathogen arms-race, the major histocompatibility complex (MHC). However, MHC duplication history is as yet poorly understood in non-mammalian vertebrates, including birds. Results: Here, we provide evidence for the evolution of two ancient avian MHC class IIB (MHCIIB) lineages by a duplication event prior to the radiation of all extant birds >100 million years ago, and document the role of concerted evolution in eroding the footprints of the avian MHCIIB duplication history. Conclusions: Our results suggest that eroded footprints of gene duplication histories may mimic birth-death evolution and that in the avian MHC the presence of the two lineages may have been masked by elevated rates of concerted evolution in several taxa. Through the presence of a range of intermediate evolutionary stages along the homogenizing process of concerted evolution, the avian MHCIIB provides a remarkable illustration of the erosion of multigene family duplication history.

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Please use this url to cite or link to this publication:
author
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Birds, Birth-death evolution, Concerted evolution, Gene conversion, Gene duplication, Major histocompatibility complex, Recombination
in
BMC Genomics
volume
18
issue
1
publisher
BMC Genomics
external identifiers
  • scopus:85020646288
ISSN
1471-2164
DOI
10.1186/s12864-017-3839-7
language
English
LU publication?
no
id
9fe0a651-e46c-42b6-b19d-597462cd1739
date added to LUP
2017-07-04 10:29:56
date last changed
2018-04-22 04:30:20
@article{9fe0a651-e46c-42b6-b19d-597462cd1739,
  abstract     = {<p>Background: Gene duplication has led to a most remarkable adaptation involved in vertebrates' host-pathogen arms-race, the major histocompatibility complex (MHC). However, MHC duplication history is as yet poorly understood in non-mammalian vertebrates, including birds. Results: Here, we provide evidence for the evolution of two ancient avian MHC class IIB (MHCIIB) lineages by a duplication event prior to the radiation of all extant birds &gt;100 million years ago, and document the role of concerted evolution in eroding the footprints of the avian MHCIIB duplication history. Conclusions: Our results suggest that eroded footprints of gene duplication histories may mimic birth-death evolution and that in the avian MHC the presence of the two lineages may have been masked by elevated rates of concerted evolution in several taxa. Through the presence of a range of intermediate evolutionary stages along the homogenizing process of concerted evolution, the avian MHCIIB provides a remarkable illustration of the erosion of multigene family duplication history.</p>},
  articleno    = {460},
  author       = {Goebel, Julien and Promerová, Marta and Bonadonna, Francesco and McCoy, Karen D. and Serbielle, Céline and Strandh, Maria and Yannic, Glenn and Burri, Reto and Fumagalli, Luca},
  issn         = {1471-2164},
  keyword      = {Birds,Birth-death evolution,Concerted evolution,Gene conversion,Gene duplication,Major histocompatibility complex,Recombination},
  language     = {eng},
  month        = {06},
  number       = {1},
  publisher    = {BMC Genomics},
  series       = {BMC Genomics},
  title        = {100 million years of multigene family evolution : Origin and evolution of the avian MHC class IIB},
  url          = {http://dx.doi.org/10.1186/s12864-017-3839-7},
  volume       = {18},
  year         = {2017},
}