Psychological, pharmacological, and combined treatments for binge eating disorder : A systematic review and metaanalysis
Ghaderi, Ata ; Odeberg, Jenny ; Gustafsson, Sanna ; Rastam, Maria LU
; Brolund, Agneta
; Pettersson, Agneta
and Parling, Thomas
(2018)
In PeerJ
2018(6).
- Abstract
Objective: To systematically review the efficacy of psychological, pharmacological, and combined treatments for binge eating disorder (BED). Method: Systematic search and meta-analysis. Results: We found 45 unique studies with low/medium risk of bias, and moderate support for the efficacy of cognitive behavior therapy (CBT) and CBT guided selfhelp (with moderate quality of evidence), and modest support for interpersonal psychotherapy (IPT), selective serotonin reuptake inhibitors (SSRI), and lisdexamfetamine (with low quality of evidence) in the treatment of adults with BED in terms of cessation of or reduction in the frequency of binge eating. The results on weight loss were disappointing. Only lisdexamfetamine showed a very modest... (More)
Objective: To systematically review the efficacy of psychological, pharmacological, and combined treatments for binge eating disorder (BED). Method: Systematic search and meta-analysis. Results: We found 45 unique studies with low/medium risk of bias, and moderate support for the efficacy of cognitive behavior therapy (CBT) and CBT guided selfhelp (with moderate quality of evidence), and modest support for interpersonal psychotherapy (IPT), selective serotonin reuptake inhibitors (SSRI), and lisdexamfetamine (with low quality of evidence) in the treatment of adults with BED in terms of cessation of or reduction in the frequency of binge eating. The results on weight loss were disappointing. Only lisdexamfetamine showed a very modest effect on weight loss (low quality of evidence).While there is limited support for the longterm effect of psychological treatments, we have currently no data to ascertain the long-term effect of drug treatments. Some undesired side effects are more common in drug treatment compared to placebo, while the side effects of psychological treatments are unknown. Direct comparisons between pharmaceutical and psychological treatments are lacking as well as data to generalize these results to adolescents. Conclusion: We found moderate support for the efficacy of CBT and guided selfhelp for the treatment of BED. However, IPT, SSRI, and lisdexamfetamine received only modest support in terms of cessation of or reduction in the frequency of binge eating. The lack of long-term follow-ups is alarming, especially with regard to medication. Long-term follow-ups, standardized assessments including measures of quality of life, and the study of underrepresented populations should be a priority for future research.
(Less)
- author
- Ghaderi, Ata
; Odeberg, Jenny
; Gustafsson, Sanna
; Rastam, Maria
LU
; Brolund, Agneta
; Pettersson, Agneta
and Parling, Thomas
- organization
- publishing date
- 2018-01-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Binge eating disorder, Eating disorder, Lisdexamfetamine, Meta-analysis, Psychotherapy, SSRI
- in
- PeerJ
- volume
- 2018
- issue
- 6
- article number
- e5113
- publisher
- PeerJ
- external identifiers
-
- scopus:85048936525
- pmid:29942715
- ISSN
- 2167-8359
- DOI
- 10.7717/peerj.5113
- language
- English
- LU publication?
- yes
- id
- a01716e0-e262-4199-a1a2-8d4cb94daba0
- date added to LUP
- 2018-07-06 14:31:45
- date last changed
- 2024-06-10 14:50:33
@article{a01716e0-e262-4199-a1a2-8d4cb94daba0,
abstract = {{<p>Objective: To systematically review the efficacy of psychological, pharmacological, and combined treatments for binge eating disorder (BED). Method: Systematic search and meta-analysis. Results: We found 45 unique studies with low/medium risk of bias, and moderate support for the efficacy of cognitive behavior therapy (CBT) and CBT guided selfhelp (with moderate quality of evidence), and modest support for interpersonal psychotherapy (IPT), selective serotonin reuptake inhibitors (SSRI), and lisdexamfetamine (with low quality of evidence) in the treatment of adults with BED in terms of cessation of or reduction in the frequency of binge eating. The results on weight loss were disappointing. Only lisdexamfetamine showed a very modest effect on weight loss (low quality of evidence).While there is limited support for the longterm effect of psychological treatments, we have currently no data to ascertain the long-term effect of drug treatments. Some undesired side effects are more common in drug treatment compared to placebo, while the side effects of psychological treatments are unknown. Direct comparisons between pharmaceutical and psychological treatments are lacking as well as data to generalize these results to adolescents. Conclusion: We found moderate support for the efficacy of CBT and guided selfhelp for the treatment of BED. However, IPT, SSRI, and lisdexamfetamine received only modest support in terms of cessation of or reduction in the frequency of binge eating. The lack of long-term follow-ups is alarming, especially with regard to medication. Long-term follow-ups, standardized assessments including measures of quality of life, and the study of underrepresented populations should be a priority for future research.</p>}},
author = {{Ghaderi, Ata and Odeberg, Jenny and Gustafsson, Sanna and Rastam, Maria and Brolund, Agneta and Pettersson, Agneta and Parling, Thomas}},
issn = {{2167-8359}},
keywords = {{Binge eating disorder; Eating disorder; Lisdexamfetamine; Meta-analysis; Psychotherapy; SSRI}},
language = {{eng}},
month = {{01}},
number = {{6}},
publisher = {{PeerJ}},
series = {{PeerJ}},
title = {{Psychological, pharmacological, and combined treatments for binge eating disorder : A systematic review and metaanalysis}},
url = {{http://dx.doi.org/10.7717/peerj.5113}},
doi = {{10.7717/peerj.5113}},
volume = {{2018}},
year = {{2018}},
}