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Leukemia inhibitory factor null mice : Unhampered in vitro outgrowth of sensory axons but reduced stimulatory potential by nerve segments

Ekström, Per A R LU ; Kerekes, Nóra LU and Hökfelt, Tomas (2000) In Neuroscience Letters 281(2-3). p.107-110
Abstract

Leukemia inhibitory factor (LIF) is locally up-regulated after peripheral nerve injury and may be involved in the subsequent regeneration. Here, adult mice with or without LIF gene deletions were used to study the role of LIF in regeneration. The results show that axonal regeneration in vitro from dorsal root ganglia (DRGs) was unaffected by LIF deletion. However, segments from wild type mice promoted DRG axonal outgrowth better than segments from LIF deleted animals when in vivo-injured sciatic nerve segments were co-cultured with DRGs from normal adult mice. Addition of LIF could not restore the deficit. This suggests that LIF is engaged in the local regulation of regeneration but not in the regenerative events occuring at the cell... (More)

Leukemia inhibitory factor (LIF) is locally up-regulated after peripheral nerve injury and may be involved in the subsequent regeneration. Here, adult mice with or without LIF gene deletions were used to study the role of LIF in regeneration. The results show that axonal regeneration in vitro from dorsal root ganglia (DRGs) was unaffected by LIF deletion. However, segments from wild type mice promoted DRG axonal outgrowth better than segments from LIF deleted animals when in vivo-injured sciatic nerve segments were co-cultured with DRGs from normal adult mice. Addition of LIF could not restore the deficit. This suggests that LIF is engaged in the local regulation of regeneration but not in the regenerative events occuring at the cell body level. (C) 2000 Elsevier Science Ireland Ltd.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Conditioning lesion, Dorsal root ganglia, Knock-out, Neurite outgrowth, Regeneration, Stimulation
in
Neuroscience Letters
volume
281
issue
2-3
pages
4 pages
publisher
Elsevier
external identifiers
  • scopus:0033999591
ISSN
0304-3940
DOI
10.1016/S0304-3940(00)00816-8
language
English
LU publication?
yes
id
a02214d3-a136-4bad-af81-a9f03634c053
date added to LUP
2016-12-07 14:44:43
date last changed
2017-06-02 12:38:37
@article{a02214d3-a136-4bad-af81-a9f03634c053,
  abstract     = {<p>Leukemia inhibitory factor (LIF) is locally up-regulated after peripheral nerve injury and may be involved in the subsequent regeneration. Here, adult mice with or without LIF gene deletions were used to study the role of LIF in regeneration. The results show that axonal regeneration in vitro from dorsal root ganglia (DRGs) was unaffected by LIF deletion. However, segments from wild type mice promoted DRG axonal outgrowth better than segments from LIF deleted animals when in vivo-injured sciatic nerve segments were co-cultured with DRGs from normal adult mice. Addition of LIF could not restore the deficit. This suggests that LIF is engaged in the local regulation of regeneration but not in the regenerative events occuring at the cell body level. (C) 2000 Elsevier Science Ireland Ltd.</p>},
  author       = {Ekström, Per A R and Kerekes, Nóra and Hökfelt, Tomas},
  issn         = {0304-3940},
  keyword      = {Conditioning lesion,Dorsal root ganglia,Knock-out,Neurite outgrowth,Regeneration,Stimulation},
  language     = {eng},
  month        = {03},
  number       = {2-3},
  pages        = {107--110},
  publisher    = {Elsevier},
  series       = {Neuroscience Letters},
  title        = {Leukemia inhibitory factor null mice : Unhampered in vitro outgrowth of sensory axons but reduced stimulatory potential by nerve segments},
  url          = {http://dx.doi.org/10.1016/S0304-3940(00)00816-8},
  volume       = {281},
  year         = {2000},
}