Bacterial attachment to uro-epithelial cells : mechanisms and consequences.
(1997) In Advances in dental research 11(1). p.50-58- Abstract
Microbial attachment to mucosal surfaces is a first step in mucosal infection. Specific interactions between microbial surface ligands and host receptors influence the distribution of microbes in their sites of infection. Adhesion has often been regarded as a sufficient end point, explaining tissue tropism and bacterial persistence at mucosal sites. Adherence, however, is also a virulence factor through which microbes gain access to host tissues, upset the integrity of the mucosal barrier, and cause disease. The induction of mucosal inflammation is one aspect of this process. Bacterial attachment to mucosal surfaces activates the production of pro-inflammatory cytokines that cause both local and systemic inflammation. Epithelial cells... (More)
Microbial attachment to mucosal surfaces is a first step in mucosal infection. Specific interactions between microbial surface ligands and host receptors influence the distribution of microbes in their sites of infection. Adhesion has often been regarded as a sufficient end point, explaining tissue tropism and bacterial persistence at mucosal sites. Adherence, however, is also a virulence factor through which microbes gain access to host tissues, upset the integrity of the mucosal barrier, and cause disease. The induction of mucosal inflammation is one aspect of this process. Bacterial attachment to mucosal surfaces activates the production of pro-inflammatory cytokines that cause both local and systemic inflammation. Epithelial cells are one source of these cytokines. The binding of fimbrial lectins to epithelial cell receptors triggers transmembrane signaling events that upregulate cytokine-specific mRNA and increase cytokine secretion. P fimbriae that bind the globoseries of glycolipids cause the release of ceramides and activation of the ceramide signaling pathway which contributes to the IL-6 response. Spread of cytokines and other pro-inflammatory mediators from the local site contributes to the symptoms and signs of infection.
(Less)
- author
- Connell, H. LU ; Hedlund, M. LU ; Agace, W. LU and Svanborg, C. LU
- organization
- publishing date
- 1997-01-01
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Advances in dental research
- volume
- 11
- issue
- 1
- pages
- 50 - 58
- publisher
- International Association for Dental Research
- external identifiers
-
- pmid:9524442
- scopus:0031107555
- ISSN
- 0895-9374
- DOI
- 10.1177/08959374970110011701
- language
- English
- LU publication?
- yes
- id
- a025e677-a5cb-46c0-9bca-caee69f4d956
- date added to LUP
- 2019-05-30 13:51:31
- date last changed
- 2024-04-02 06:14:03
@article{a025e677-a5cb-46c0-9bca-caee69f4d956,
abstract = {{<p>Microbial attachment to mucosal surfaces is a first step in mucosal infection. Specific interactions between microbial surface ligands and host receptors influence the distribution of microbes in their sites of infection. Adhesion has often been regarded as a sufficient end point, explaining tissue tropism and bacterial persistence at mucosal sites. Adherence, however, is also a virulence factor through which microbes gain access to host tissues, upset the integrity of the mucosal barrier, and cause disease. The induction of mucosal inflammation is one aspect of this process. Bacterial attachment to mucosal surfaces activates the production of pro-inflammatory cytokines that cause both local and systemic inflammation. Epithelial cells are one source of these cytokines. The binding of fimbrial lectins to epithelial cell receptors triggers transmembrane signaling events that upregulate cytokine-specific mRNA and increase cytokine secretion. P fimbriae that bind the globoseries of glycolipids cause the release of ceramides and activation of the ceramide signaling pathway which contributes to the IL-6 response. Spread of cytokines and other pro-inflammatory mediators from the local site contributes to the symptoms and signs of infection.</p>}},
author = {{Connell, H. and Hedlund, M. and Agace, W. and Svanborg, C.}},
issn = {{0895-9374}},
language = {{eng}},
month = {{01}},
number = {{1}},
pages = {{50--58}},
publisher = {{International Association for Dental Research}},
series = {{Advances in dental research}},
title = {{Bacterial attachment to uro-epithelial cells : mechanisms and consequences.}},
url = {{http://dx.doi.org/10.1177/08959374970110011701}},
doi = {{10.1177/08959374970110011701}},
volume = {{11}},
year = {{1997}},
}