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Cardiovascular changes in patients with mild-to-moderate chronic kidney disease compared with healthy subjects : a 5-year follow-up study

Asp, Anna M. ; Wallquist, Carin LU ; Rickenlund, Anette ; Hylander, Britta ; Jacobson, Stefan H. ; Caidahl, Kenneth and Eriksson, Maria J. (2019) In Clinical Physiology and Functional Imaging
Abstract

Background: There is limited knowledge about how cardiovascular parameters change over time in patients with mild-to-moderate chronic kidney disease (CKD). We studied several cardiovascular biomarkers over a 5-year period in patients with mild-to-moderate CKD and in healthy controls. Methods: Fifty-four patients with CKD stages 2–3 and 54 controls were included. The CKD patients were closely monitored and well controlled for hypertension and other cardiovascular risk factors. Ambulatory blood pressure (BP) monitoring, ankle–brachial index (ABI), carotid and cardiac ultrasound (including measurement of the left ventricular mass index (LVMI)), and biochemical analyses were evaluated. Results: Renal function decreased in both groups, with... (More)

Background: There is limited knowledge about how cardiovascular parameters change over time in patients with mild-to-moderate chronic kidney disease (CKD). We studied several cardiovascular biomarkers over a 5-year period in patients with mild-to-moderate CKD and in healthy controls. Methods: Fifty-four patients with CKD stages 2–3 and 54 controls were included. The CKD patients were closely monitored and well controlled for hypertension and other cardiovascular risk factors. Ambulatory blood pressure (BP) monitoring, ankle–brachial index (ABI), carotid and cardiac ultrasound (including measurement of the left ventricular mass index (LVMI)), and biochemical analyses were evaluated. Results: Renal function decreased in both groups, with no significant difference in the change over time. In the CKD patients, none of the BP variables increased over time, but in the controls, average 24-h and daytime systolic BP increased significantly. ABI increased slightly in the CKD patients (P<0·001), but not in the controls (P = 0·963), and phosphate had a significant positive effect on ABI. Although in the CKD patients, there was no significant increase over time in common carotid artery diameter (P = 0·274), there was a small but significant increase in the controls (P = 0·001). LVMI increased significantly over time in both groups. Conclusions: In our study of patients with mild-to-moderate CKD, the progression of cardiovascular changes over time was relatively slow. Good BP control and treatment of other risk factors may have contributed to slow the progress of cardiovascular involvement, which emphasizes the importance of dedicated care in this population.

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author
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publishing date
type
Contribution to journal
publication status
epub
subject
keywords
ankle–brachial index, arterial remodelling, arterial stiffness, blood pressure, carotid ultrasound, left ventricular hypertrophy, renal insufficiency, transthoracic echocardiography
in
Clinical Physiology and Functional Imaging
publisher
Wiley Online Library
external identifiers
  • pmid:31701609
  • scopus:85075436580
ISSN
1475-0961
DOI
10.1111/cpf.12607
language
English
LU publication?
no
id
a030d471-25b4-45f1-b185-abe06656989c
date added to LUP
2019-12-11 11:04:24
date last changed
2020-01-13 02:35:49
@article{a030d471-25b4-45f1-b185-abe06656989c,
  abstract     = {<p>Background: There is limited knowledge about how cardiovascular parameters change over time in patients with mild-to-moderate chronic kidney disease (CKD). We studied several cardiovascular biomarkers over a 5-year period in patients with mild-to-moderate CKD and in healthy controls. Methods: Fifty-four patients with CKD stages 2–3 and 54 controls were included. The CKD patients were closely monitored and well controlled for hypertension and other cardiovascular risk factors. Ambulatory blood pressure (BP) monitoring, ankle–brachial index (ABI), carotid and cardiac ultrasound (including measurement of the left ventricular mass index (LVMI)), and biochemical analyses were evaluated. Results: Renal function decreased in both groups, with no significant difference in the change over time. In the CKD patients, none of the BP variables increased over time, but in the controls, average 24-h and daytime systolic BP increased significantly. ABI increased slightly in the CKD patients (P&lt;0·001), but not in the controls (P = 0·963), and phosphate had a significant positive effect on ABI. Although in the CKD patients, there was no significant increase over time in common carotid artery diameter (P = 0·274), there was a small but significant increase in the controls (P = 0·001). LVMI increased significantly over time in both groups. Conclusions: In our study of patients with mild-to-moderate CKD, the progression of cardiovascular changes over time was relatively slow. Good BP control and treatment of other risk factors may have contributed to slow the progress of cardiovascular involvement, which emphasizes the importance of dedicated care in this population.</p>},
  author       = {Asp, Anna M. and Wallquist, Carin and Rickenlund, Anette and Hylander, Britta and Jacobson, Stefan H. and Caidahl, Kenneth and Eriksson, Maria J.},
  issn         = {1475-0961},
  language     = {eng},
  month        = {11},
  publisher    = {Wiley Online Library},
  series       = {Clinical Physiology and Functional Imaging},
  title        = {Cardiovascular changes in patients with mild-to-moderate chronic kidney disease compared with healthy subjects : a 5-year follow-up study},
  url          = {http://dx.doi.org/10.1111/cpf.12607},
  doi          = {10.1111/cpf.12607},
  year         = {2019},
}