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Increased intestinal marker absorption due to regional permeability changes and decreased intestinal transit during sepsis in the rat

Wang, Q. ; Pantzar, N. ; Jeppsson, B. LU ; Weström, B. R. LU and Karlsson, B. W. LU (1994) In Scandinavian Journal of Gastroenterology 29(11). p.1001-1008
Abstract

Wang Q, Pantzar N. Jeppsson B, Weström BR, Karlsson BW. Increased intestinal marker absorption due to regional permeability changes and decreased intestinal transit during sepsis in the rat. Scand J Gastroenterol 1994;29:1001-1008. Background: The intestinal barrier properties are impaired during inflammation and sepsis, but the mechanisms behind this are unknown and were therefore investigated during experimental sepsis in rats. Methods: The different-sized intestinal absorption markers 51Cr-labeled ethylenediaminetetraacetic acid (EDTA) and ovalbumin were gavaged to rats made septic by intra-abdominal bacterial implantation and to sham-operated rats. Regional tissue permeability was measured in diffusion chambers, and... (More)

Wang Q, Pantzar N. Jeppsson B, Weström BR, Karlsson BW. Increased intestinal marker absorption due to regional permeability changes and decreased intestinal transit during sepsis in the rat. Scand J Gastroenterol 1994;29:1001-1008. Background: The intestinal barrier properties are impaired during inflammation and sepsis, but the mechanisms behind this are unknown and were therefore investigated during experimental sepsis in rats. Methods: The different-sized intestinal absorption markers 51Cr-labeled ethylenediaminetetraacetic acid (EDTA) and ovalbumin were gavaged to rats made septic by intra-abdominal bacterial implantation and to sham-operated rats. Regional tissue permeability was measured in diffusion chambers, and intestinal transit was evaluated by intestinal accumulation of gavaged 51Cr-EDTA. Results: In comparison with the sham-operated rats, septic rats had higher 51Cr-EDTA levels in blood and urine and showed a prolonged intestinal transit. Septic rats also had a lower tissue permeability to both markers in the small intestines but higher permeability to ovalbumin in the colon. Rats receiving morphine to decrease intestinal motility showed similar changes, with a decreased intestinal transit and increased marker absorption. Conclusions: The results suggest that the increased intestinal absorption during sepsis was due to regional permeability changes and prolonged intestinal transit.

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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Diffusion chamber, Intestine, Morphine, Ovalbumin, Permeability, Rat, Sepsis, Transit
in
Scandinavian Journal of Gastroenterology
volume
29
issue
11
pages
8 pages
publisher
Taylor & Francis
external identifiers
  • pmid:7871365
  • scopus:0028046118
ISSN
0036-5521
DOI
10.3109/00365529409094877
language
English
LU publication?
yes
id
a03e472b-cce4-4d31-9537-93ec91af1ca2
date added to LUP
2024-12-05 15:35:47
date last changed
2025-04-10 07:59:56
@article{a03e472b-cce4-4d31-9537-93ec91af1ca2,
  abstract     = {{<p>Wang Q, Pantzar N. Jeppsson B, Weström BR, Karlsson BW. Increased intestinal marker absorption due to regional permeability changes and decreased intestinal transit during sepsis in the rat. Scand J Gastroenterol 1994;29:1001-1008. Background: The intestinal barrier properties are impaired during inflammation and sepsis, but the mechanisms behind this are unknown and were therefore investigated during experimental sepsis in rats. Methods: The different-sized intestinal absorption markers <sup>51</sup>Cr-labeled ethylenediaminetetraacetic acid (EDTA) and ovalbumin were gavaged to rats made septic by intra-abdominal bacterial implantation and to sham-operated rats. Regional tissue permeability was measured in diffusion chambers, and intestinal transit was evaluated by intestinal accumulation of gavaged <sup>51</sup>Cr-EDTA. Results: In comparison with the sham-operated rats, septic rats had higher <sup>51</sup>Cr-EDTA levels in blood and urine and showed a prolonged intestinal transit. Septic rats also had a lower tissue permeability to both markers in the small intestines but higher permeability to ovalbumin in the colon. Rats receiving morphine to decrease intestinal motility showed similar changes, with a decreased intestinal transit and increased marker absorption. Conclusions: The results suggest that the increased intestinal absorption during sepsis was due to regional permeability changes and prolonged intestinal transit.</p>}},
  author       = {{Wang, Q. and Pantzar, N. and Jeppsson, B. and Weström, B. R. and Karlsson, B. W.}},
  issn         = {{0036-5521}},
  keywords     = {{Diffusion chamber; Intestine; Morphine; Ovalbumin; Permeability; Rat; Sepsis; Transit}},
  language     = {{eng}},
  number       = {{11}},
  pages        = {{1001--1008}},
  publisher    = {{Taylor & Francis}},
  series       = {{Scandinavian Journal of Gastroenterology}},
  title        = {{Increased intestinal marker absorption due to regional permeability changes and decreased intestinal transit during sepsis in the rat}},
  url          = {{http://dx.doi.org/10.3109/00365529409094877}},
  doi          = {{10.3109/00365529409094877}},
  volume       = {{29}},
  year         = {{1994}},
}