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Cachexia: a problem of energetic inefficiency

Argilés, Josep M; Fontes-Oliveira, Cibely Cristine LU ; Toledo, Miriam; López-Soriano, Francisco J and Busquets, Sílvia (2014) In Journal of Cachexia, Sarcopenia and Muscle 5(4). p.86-279
Abstract

An alteration of energy balance is the immediate cause of the so-called cachexia. Although alterations of energy intake are often associated with cachexia, it has lately became clear that an increased energy expenditure is the main cause of wasting associated with different types of pathological conditions, such as cancer, infections or chronic heart failure among others. Different types of molecular mechanisms contribute to energy expenditure and, therefore, involuntary body weight loss; among them, adenosine triphosphate (ATP) consumption by sarcoplasmic reticulum Ca(2+) pumps could represent a key mechanism. In other cases, an increase in energy inefficiency will further contribute to energy imbalance.

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author
publishing date
type
Contribution to journal
publication status
published
keywords
Journal Article
in
Journal of Cachexia, Sarcopenia and Muscle
volume
5
issue
4
pages
86 - 279
publisher
Wiley-Blackwell
external identifiers
  • scopus:84951560724
ISSN
2190-5991
DOI
10.1007/s13539-014-0154-x
language
English
LU publication?
no
id
a04a80a1-8def-44ee-a3b5-7d46ac6520f6
date added to LUP
2017-02-28 16:09:39
date last changed
2017-11-05 05:14:36
@article{a04a80a1-8def-44ee-a3b5-7d46ac6520f6,
  abstract     = {<p>An alteration of energy balance is the immediate cause of the so-called cachexia. Although alterations of energy intake are often associated with cachexia, it has lately became clear that an increased energy expenditure is the main cause of wasting associated with different types of pathological conditions, such as cancer, infections or chronic heart failure among others. Different types of molecular mechanisms contribute to energy expenditure and, therefore, involuntary body weight loss; among them, adenosine triphosphate (ATP) consumption by sarcoplasmic reticulum Ca(2+) pumps could represent a key mechanism. In other cases, an increase in energy inefficiency will further contribute to energy imbalance.</p>},
  author       = {Argilés, Josep M and Fontes-Oliveira, Cibely Cristine and Toledo, Miriam and López-Soriano, Francisco J and Busquets, Sílvia},
  issn         = {2190-5991},
  keyword      = {Journal Article},
  language     = {eng},
  number       = {4},
  pages        = {86--279},
  publisher    = {Wiley-Blackwell},
  series       = {Journal of Cachexia, Sarcopenia and Muscle},
  title        = {Cachexia: a problem of energetic inefficiency},
  url          = {http://dx.doi.org/10.1007/s13539-014-0154-x},
  volume       = {5},
  year         = {2014},
}