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Early ageing in middle-aged men is associated with adverse social factors and increased mortality risk: The Malmö Preventive Project.

Tell, David and Nilsson, Peter LU (2006) In Scandinavian Journal of Public Health 34(4). p.346-352
Abstract
Aims: This study examined whether middle-aged men exhibiting markers of early ageing showed a different pattern of social factors, lifestyle, and biological variables compared with controls, and whether early ageing was associated with an increased mortality risk. Subjects and methods: We used a subgroup of 5,722 middle-aged men (mean age 47 years), investigated twice, from the Malmö Preventive Project (MPP), a screening programme attended by a total of 22,444 men between 1974 and 1992. Markers of biological ageing, such as decreased lung function, increased pulse pressure, and decreased height, were used to identify early aged subjects and a control group. These were followed up by use of local and national registers for a mean of 22... (More)
Aims: This study examined whether middle-aged men exhibiting markers of early ageing showed a different pattern of social factors, lifestyle, and biological variables compared with controls, and whether early ageing was associated with an increased mortality risk. Subjects and methods: We used a subgroup of 5,722 middle-aged men (mean age 47 years), investigated twice, from the Malmö Preventive Project (MPP), a screening programme attended by a total of 22,444 men between 1974 and 1992. Markers of biological ageing, such as decreased lung function, increased pulse pressure, and decreased height, were used to identify early aged subjects and a control group. These were followed up by use of local and national registers for a mean of 22 years. Cox's proportional regression was used to estimate multivariate relative risks (RR) for mortality with 95% confidence intervals (CI). Results: Men with early ageing were more often smokers, living alone, or less likely to be non-manual workers than control subjects. These men also had an increased age-adjusted mortality relative risk, RR 1.29 (95% CI 1.10-1.52). After adjustment for social and lifestyle factor there was still a significant difference in mortality between the two groups, RR 1.19 (95% CI 1.00-1.42). Conclusion: Early biological ageing in middle-aged men is associated with an increased mortality risk during long-term follow-up that cannot be fully explained by social background characteristics or adverse lifestyle. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
lung function, height, Ageing, men, pulse pressure, social class, smoking
in
Scandinavian Journal of Public Health
volume
34
issue
4
pages
346 - 352
publisher
SAGE Publications Inc.
external identifiers
  • pmid:16861184
  • wos:000239593300003
  • scopus:33746478602
ISSN
1651-1905
DOI
10.1080/14034940500489834
language
English
LU publication?
yes
id
a06e0812-e521-4fbf-af2f-033ba8228a32 (old id 158856)
date added to LUP
2016-04-01 17:02:57
date last changed
2019-11-13 03:42:10
@article{a06e0812-e521-4fbf-af2f-033ba8228a32,
  abstract     = {Aims: This study examined whether middle-aged men exhibiting markers of early ageing showed a different pattern of social factors, lifestyle, and biological variables compared with controls, and whether early ageing was associated with an increased mortality risk. Subjects and methods: We used a subgroup of 5,722 middle-aged men (mean age 47 years), investigated twice, from the Malmö Preventive Project (MPP), a screening programme attended by a total of 22,444 men between 1974 and 1992. Markers of biological ageing, such as decreased lung function, increased pulse pressure, and decreased height, were used to identify early aged subjects and a control group. These were followed up by use of local and national registers for a mean of 22 years. Cox's proportional regression was used to estimate multivariate relative risks (RR) for mortality with 95% confidence intervals (CI). Results: Men with early ageing were more often smokers, living alone, or less likely to be non-manual workers than control subjects. These men also had an increased age-adjusted mortality relative risk, RR 1.29 (95% CI 1.10-1.52). After adjustment for social and lifestyle factor there was still a significant difference in mortality between the two groups, RR 1.19 (95% CI 1.00-1.42). Conclusion: Early biological ageing in middle-aged men is associated with an increased mortality risk during long-term follow-up that cannot be fully explained by social background characteristics or adverse lifestyle.},
  author       = {Tell, David and Nilsson, Peter},
  issn         = {1651-1905},
  language     = {eng},
  number       = {4},
  pages        = {346--352},
  publisher    = {SAGE Publications Inc.},
  series       = {Scandinavian Journal of Public Health},
  title        = {Early ageing in middle-aged men is associated with adverse social factors and increased mortality risk: The Malmö Preventive Project.},
  url          = {http://dx.doi.org/10.1080/14034940500489834},
  doi          = {10.1080/14034940500489834},
  volume       = {34},
  year         = {2006},
}