In vitro studies on the effect of in vivo zinc deficiency on the formation of glycos-aminoglycans in rat costal cartilage
Lohmander, Stefan LU
; Friberg, Ulf
and Bergman, Bo
(1972)
In Acta Odontologica Scandinavica
30(1).
p.89-96
- Abstract
The effects of in vivo zinc deficiency and restricted food intake, on the in vitro synthesis of glycosaminoglycans of rib cartilage were studied in the rat. 35S-sulfate and 14C-glucosamine were used as precursors. The glycosaminoglycans were separated on microcolumns and specific radioactivities determined for the different fractions. Chemical analyses showed that zinc deficiency or reduced food intake did not cause any qualitative or quantitative changes in the glycosaminoglycans. The radioassays indicated that zinc deficiency and reduced food intake, alone or combined, caused a somewhat lowered synthetic rate of chondroitin sulfate. In the discussion it is underlined that it seems difficult to determine... (More)
The effects of in vivo zinc deficiency and restricted food intake, on the in vitro synthesis of glycosaminoglycans of rib cartilage were studied in the rat. 35S-sulfate and 14C-glucosamine were used as precursors. The glycosaminoglycans were separated on microcolumns and specific radioactivities determined for the different fractions. Chemical analyses showed that zinc deficiency or reduced food intake did not cause any qualitative or quantitative changes in the glycosaminoglycans. The radioassays indicated that zinc deficiency and reduced food intake, alone or combined, caused a somewhat lowered synthetic rate of chondroitin sulfate. In the discussion it is underlined that it seems difficult to determine conclusively the importance of zinc for the formation of the mucopolysaccharides through further in vivo deficiency studies, because of the difficulties to control and evaluate the inanition factor.
(Less)
- author
- Lohmander, Stefan
LU
; Friberg, Ulf
and Bergman, Bo
- organization
- publishing date
- 1972
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Cartilage, Deficiency diseases, Rats, Zinc
- in
- Acta Odontologica Scandinavica
- volume
- 30
- issue
- 1
- pages
- 8 pages
- publisher
- Taylor & Francis
- external identifiers
-
- pmid:4260934
- scopus:0015311646
- ISSN
- 0001-6357
- DOI
- 10.3109/00016357209004594
- language
- English
- LU publication?
- yes
- id
- a0700c30-8274-4460-8f27-8fabb7b7130f
- date added to LUP
- 2016-05-04 12:36:16
- date last changed
- 2024-01-04 02:33:20
@article{a0700c30-8274-4460-8f27-8fabb7b7130f,
abstract = {{<p>The effects of in vivo zinc deficiency and restricted food intake, on the in vitro synthesis of glycosaminoglycans of rib cartilage were studied in the rat. <sup>35</sup>S-sulfate and <sup>14</sup>C-glucosamine were used as precursors. The glycosaminoglycans were separated on microcolumns and specific radioactivities determined for the different fractions. Chemical analyses showed that zinc deficiency or reduced food intake did not cause any qualitative or quantitative changes in the glycosaminoglycans. The radioassays indicated that zinc deficiency and reduced food intake, alone or combined, caused a somewhat lowered synthetic rate of chondroitin sulfate. In the discussion it is underlined that it seems difficult to determine conclusively the importance of zinc for the formation of the mucopolysaccharides through further in vivo deficiency studies, because of the difficulties to control and evaluate the inanition factor.</p>}},
author = {{Lohmander, Stefan and Friberg, Ulf and Bergman, Bo}},
issn = {{0001-6357}},
keywords = {{Cartilage; Deficiency diseases; Rats; Zinc}},
language = {{eng}},
number = {{1}},
pages = {{89--96}},
publisher = {{Taylor & Francis}},
series = {{Acta Odontologica Scandinavica}},
title = {{In vitro studies on the effect of in vivo zinc deficiency on the formation of glycos-aminoglycans in rat costal cartilage}},
url = {{http://dx.doi.org/10.3109/00016357209004594}},
doi = {{10.3109/00016357209004594}},
volume = {{30}},
year = {{1972}},
}