Tumor-associated fibrosis : a unique mechanism promoting ovarian cancer metastasis and peritoneal dissemination
(2024) In Cancer and Metastasis Reviews- Abstract
Epithelial ovarian cancer (EOC) is often diagnosed in advanced stage with peritoneal dissemination. Recent studies indicate that aberrant accumulation of collagen fibers in tumor stroma has a variety of effects on tumor progression. We refer to remodeled fibrous stroma with altered expression of collagen molecules, increased stiffness, and highly oriented collagen fibers as tumor-associated fibrosis (TAF). TAF contributes to EOC cell invasion and metastasis in the intraperitoneal cavity. However, an understanding of molecular events involved is only just beginning to emerge. Further development in this field will lead to new strategies to treat EOC. In this review, we focus on the recent findings on how the TAF contributes to EOC... (More)
Epithelial ovarian cancer (EOC) is often diagnosed in advanced stage with peritoneal dissemination. Recent studies indicate that aberrant accumulation of collagen fibers in tumor stroma has a variety of effects on tumor progression. We refer to remodeled fibrous stroma with altered expression of collagen molecules, increased stiffness, and highly oriented collagen fibers as tumor-associated fibrosis (TAF). TAF contributes to EOC cell invasion and metastasis in the intraperitoneal cavity. However, an understanding of molecular events involved is only just beginning to emerge. Further development in this field will lead to new strategies to treat EOC. In this review, we focus on the recent findings on how the TAF contributes to EOC malignancy. Furthermore, we will review the recent initiatives and future therapeutic strategies for targeting TAF in EOC.
(Less)
- author
- organization
- publishing date
- 2024
- type
- Contribution to journal
- publication status
- epub
- subject
- keywords
- Extracellular matrix, Fibrosis, Mesothelial, Metastasis, Ovarian cancer
- in
- Cancer and Metastasis Reviews
- publisher
- Springer
- external identifiers
-
- pmid:38546906
- scopus:85188902858
- ISSN
- 0167-7659
- DOI
- 10.1007/s10555-024-10169-8
- language
- English
- LU publication?
- yes
- id
- a09ec8f5-0e53-4c62-92c7-b4ae24366635
- date added to LUP
- 2024-04-18 11:58:23
- date last changed
- 2024-04-19 03:00:08
@article{a09ec8f5-0e53-4c62-92c7-b4ae24366635, abstract = {{<p>Epithelial ovarian cancer (EOC) is often diagnosed in advanced stage with peritoneal dissemination. Recent studies indicate that aberrant accumulation of collagen fibers in tumor stroma has a variety of effects on tumor progression. We refer to remodeled fibrous stroma with altered expression of collagen molecules, increased stiffness, and highly oriented collagen fibers as tumor-associated fibrosis (TAF). TAF contributes to EOC cell invasion and metastasis in the intraperitoneal cavity. However, an understanding of molecular events involved is only just beginning to emerge. Further development in this field will lead to new strategies to treat EOC. In this review, we focus on the recent findings on how the TAF contributes to EOC malignancy. Furthermore, we will review the recent initiatives and future therapeutic strategies for targeting TAF in EOC.</p>}}, author = {{Fujimoto, Hiroki and Yoshihara, Masato and Rodgers, Raymond and Iyoshi, Shohei and Mogi, Kazumasa and Miyamoto, Emiri and Hayakawa, Sae and Hayashi, Maia and Nomura, Satoshi and Kitami, Kazuhisa and Uno, Kaname and Sugiyama, Mai and Koya, Yoshihiro and Yamakita, Yoshihiko and Nawa, Akihiro and Enomoto, Atsushi and Ricciardelli, Carmela and Kajiyama, Hiroaki}}, issn = {{0167-7659}}, keywords = {{Extracellular matrix; Fibrosis; Mesothelial; Metastasis; Ovarian cancer}}, language = {{eng}}, publisher = {{Springer}}, series = {{Cancer and Metastasis Reviews}}, title = {{Tumor-associated fibrosis : a unique mechanism promoting ovarian cancer metastasis and peritoneal dissemination}}, url = {{http://dx.doi.org/10.1007/s10555-024-10169-8}}, doi = {{10.1007/s10555-024-10169-8}}, year = {{2024}}, }