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Tumor-associated fibrosis : a unique mechanism promoting ovarian cancer metastasis and peritoneal dissemination

Fujimoto, Hiroki ; Yoshihara, Masato ; Rodgers, Raymond ; Iyoshi, Shohei ; Mogi, Kazumasa ; Miyamoto, Emiri ; Hayakawa, Sae ; Hayashi, Maia ; Nomura, Satoshi and Kitami, Kazuhisa , et al. (2024) In Cancer and Metastasis Reviews
Abstract

Epithelial ovarian cancer (EOC) is often diagnosed in advanced stage with peritoneal dissemination. Recent studies indicate that aberrant accumulation of collagen fibers in tumor stroma has a variety of effects on tumor progression. We refer to remodeled fibrous stroma with altered expression of collagen molecules, increased stiffness, and highly oriented collagen fibers as tumor-associated fibrosis (TAF). TAF contributes to EOC cell invasion and metastasis in the intraperitoneal cavity. However, an understanding of molecular events involved is only just beginning to emerge. Further development in this field will lead to new strategies to treat EOC. In this review, we focus on the recent findings on how the TAF contributes to EOC... (More)

Epithelial ovarian cancer (EOC) is often diagnosed in advanced stage with peritoneal dissemination. Recent studies indicate that aberrant accumulation of collagen fibers in tumor stroma has a variety of effects on tumor progression. We refer to remodeled fibrous stroma with altered expression of collagen molecules, increased stiffness, and highly oriented collagen fibers as tumor-associated fibrosis (TAF). TAF contributes to EOC cell invasion and metastasis in the intraperitoneal cavity. However, an understanding of molecular events involved is only just beginning to emerge. Further development in this field will lead to new strategies to treat EOC. In this review, we focus on the recent findings on how the TAF contributes to EOC malignancy. Furthermore, we will review the recent initiatives and future therapeutic strategies for targeting TAF in EOC.

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organization
publishing date
type
Contribution to journal
publication status
epub
subject
keywords
Extracellular matrix, Fibrosis, Mesothelial, Metastasis, Ovarian cancer
in
Cancer and Metastasis Reviews
publisher
Springer
external identifiers
  • pmid:38546906
  • scopus:85188902858
ISSN
0167-7659
DOI
10.1007/s10555-024-10169-8
language
English
LU publication?
yes
id
a09ec8f5-0e53-4c62-92c7-b4ae24366635
date added to LUP
2024-04-18 11:58:23
date last changed
2024-04-19 03:00:08
@article{a09ec8f5-0e53-4c62-92c7-b4ae24366635,
  abstract     = {{<p>Epithelial ovarian cancer (EOC) is often diagnosed in advanced stage with peritoneal dissemination. Recent studies indicate that aberrant accumulation of collagen fibers in tumor stroma has a variety of effects on tumor progression. We refer to remodeled fibrous stroma with altered expression of collagen molecules, increased stiffness, and highly oriented collagen fibers as tumor-associated fibrosis (TAF). TAF contributes to EOC cell invasion and metastasis in the intraperitoneal cavity. However, an understanding of molecular events involved is only just beginning to emerge. Further development in this field will lead to new strategies to treat EOC. In this review, we focus on the recent findings on how the TAF contributes to EOC malignancy. Furthermore, we will review the recent initiatives and future therapeutic strategies for targeting TAF in EOC.</p>}},
  author       = {{Fujimoto, Hiroki and Yoshihara, Masato and Rodgers, Raymond and Iyoshi, Shohei and Mogi, Kazumasa and Miyamoto, Emiri and Hayakawa, Sae and Hayashi, Maia and Nomura, Satoshi and Kitami, Kazuhisa and Uno, Kaname and Sugiyama, Mai and Koya, Yoshihiro and Yamakita, Yoshihiko and Nawa, Akihiro and Enomoto, Atsushi and Ricciardelli, Carmela and Kajiyama, Hiroaki}},
  issn         = {{0167-7659}},
  keywords     = {{Extracellular matrix; Fibrosis; Mesothelial; Metastasis; Ovarian cancer}},
  language     = {{eng}},
  publisher    = {{Springer}},
  series       = {{Cancer and Metastasis Reviews}},
  title        = {{Tumor-associated fibrosis : a unique mechanism promoting ovarian cancer metastasis and peritoneal dissemination}},
  url          = {{http://dx.doi.org/10.1007/s10555-024-10169-8}},
  doi          = {{10.1007/s10555-024-10169-8}},
  year         = {{2024}},
}