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Serum cystatin C as a determinant of glomerular filtration rate in children

Helin, I ; Axenram, M and Grubb, A LU orcid (1998) In Clinical Nephrology 49(4). p.221-225
Abstract

The serum levels of cystatin C and creatinine were determined in a population comprising 69 children, 1-16 years old, and including children with both normal and reduced glomerular filtration rate (GFR) as determined by Cr-EDTA clearance measurement. The overall correlation between the reciprocal cystatin C concentration and GFR was significantly stronger (p < 0.05) than that between the reciprocal creatinine concentration and GFR and this was true also for the subpopulation of children with reduced GFR. Receiver-operating characteristic analysis also indicated superior diagnostic accuracy of serum cystatin C compared to that of serum creatinine for reduced GFR. The serum cystatin C reference values (mean +/- 1.96 SD) determined for... (More)

The serum levels of cystatin C and creatinine were determined in a population comprising 69 children, 1-16 years old, and including children with both normal and reduced glomerular filtration rate (GFR) as determined by Cr-EDTA clearance measurement. The overall correlation between the reciprocal cystatin C concentration and GFR was significantly stronger (p < 0.05) than that between the reciprocal creatinine concentration and GFR and this was true also for the subpopulation of children with reduced GFR. Receiver-operating characteristic analysis also indicated superior diagnostic accuracy of serum cystatin C compared to that of serum creatinine for reduced GFR. The serum cystatin C reference values (mean +/- 1.96 SD) determined for children over one year of age was 0.63-1.33 mg/l, which is similar to that previously determined for adults. Serum cystatin C appears to be an attractive alternative to creatinine for estimation of GFR not only in adults, but also in children.

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type
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publication status
published
subject
keywords
Adolescent, Adult, Child, Child, Preschool, Chromium Radioisotopes, Creatinine/blood, Cystatin C, Cystatins/blood, Cysteine Proteinase Inhibitors/blood, Edetic Acid, Female, Glomerular Filtration Rate/physiology, Humans, Immunoassay, Infant, Kidney Diseases/blood, Male, ROC Curve, Sensitivity and Specificity
in
Clinical Nephrology
volume
49
issue
4
pages
221 - 225
publisher
Dustri-Verlag
external identifiers
  • pmid:9582551
  • scopus:0031919535
ISSN
0301-0430
language
English
LU publication?
yes
id
a0afa066-c19d-44c1-a47a-5296ce629bf7
date added to LUP
2021-10-29 13:11:25
date last changed
2024-05-04 16:38:28
@article{a0afa066-c19d-44c1-a47a-5296ce629bf7,
  abstract     = {{<p>The serum levels of cystatin C and creatinine were determined in a population comprising 69 children, 1-16 years old, and including children with both normal and reduced glomerular filtration rate (GFR) as determined by Cr-EDTA clearance measurement. The overall correlation between the reciprocal cystatin C concentration and GFR was significantly stronger (p &lt; 0.05) than that between the reciprocal creatinine concentration and GFR and this was true also for the subpopulation of children with reduced GFR. Receiver-operating characteristic analysis also indicated superior diagnostic accuracy of serum cystatin C compared to that of serum creatinine for reduced GFR. The serum cystatin C reference values (mean +/- 1.96 SD) determined for children over one year of age was 0.63-1.33 mg/l, which is similar to that previously determined for adults. Serum cystatin C appears to be an attractive alternative to creatinine for estimation of GFR not only in adults, but also in children.</p>}},
  author       = {{Helin, I and Axenram, M and Grubb, A}},
  issn         = {{0301-0430}},
  keywords     = {{Adolescent; Adult; Child; Child, Preschool; Chromium Radioisotopes; Creatinine/blood; Cystatin C; Cystatins/blood; Cysteine Proteinase Inhibitors/blood; Edetic Acid; Female; Glomerular Filtration Rate/physiology; Humans; Immunoassay; Infant; Kidney Diseases/blood; Male; ROC Curve; Sensitivity and Specificity}},
  language     = {{eng}},
  number       = {{4}},
  pages        = {{221--225}},
  publisher    = {{Dustri-Verlag}},
  series       = {{Clinical Nephrology}},
  title        = {{Serum cystatin C as a determinant of glomerular filtration rate in children}},
  volume       = {{49}},
  year         = {{1998}},
}