Manifestation of panuveitis after intraocular surgery in a child with blau syndrome
(2021) In Middle East African Journal of Ophthalmology 28(3). p.196-198- Abstract
Blau syndrome (BS) is a rare granulomatous disease with autosomal dominant inheritance. It is characterized by a triad of dermatitis, arthritis, and recurrent uveitis. This case presents the onset of panuveitis in BS after intraocular surgery. A 10-year-old boy presented to the outpatient clinic with retinal detachment in the left eye after 6 years following early-onset cataract surgery. Bilateral panuveitis occurred 3 weeks after surgical repair and resulted in a total visual loss in the left eye and was persistent to conventional treatment in the right eye. Genetic testing revealed a mutation in NOD2 gene. The addition of adalimumab to the treatment regimen resulted in long-term uveitis control and maintenance of 20/70 vision in the... (More)
Blau syndrome (BS) is a rare granulomatous disease with autosomal dominant inheritance. It is characterized by a triad of dermatitis, arthritis, and recurrent uveitis. This case presents the onset of panuveitis in BS after intraocular surgery. A 10-year-old boy presented to the outpatient clinic with retinal detachment in the left eye after 6 years following early-onset cataract surgery. Bilateral panuveitis occurred 3 weeks after surgical repair and resulted in a total visual loss in the left eye and was persistent to conventional treatment in the right eye. Genetic testing revealed a mutation in NOD2 gene. The addition of adalimumab to the treatment regimen resulted in long-term uveitis control and maintenance of 20/70 vision in the right eye. We propose that NOD2-mediated inflammatory cascade can be activated by intraocular surgery and results in the manifestation of BS.
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- author
- Magliyah, Moustafa ; Khan, Abdullah ; Alshamrani, Mohammed ; Schatz, Patrik LU and Dhibi, Hassan
- organization
- publishing date
- 2021-07
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Blau syndrome, intraocular surgery, NOD2, panuveitis
- in
- Middle East African Journal of Ophthalmology
- volume
- 28
- issue
- 3
- pages
- 3 pages
- publisher
- Wolters Kluwer
- external identifiers
-
- pmid:35125805
- scopus:85122648080
- ISSN
- 0974-9233
- DOI
- 10.4103/meajo.meajo_15_21
- language
- English
- LU publication?
- yes
- id
- a0cec052-d2a4-46d4-84e6-d88583464a77
- date added to LUP
- 2022-03-08 14:32:57
- date last changed
- 2024-03-31 01:09:47
@article{a0cec052-d2a4-46d4-84e6-d88583464a77, abstract = {{<p>Blau syndrome (BS) is a rare granulomatous disease with autosomal dominant inheritance. It is characterized by a triad of dermatitis, arthritis, and recurrent uveitis. This case presents the onset of panuveitis in BS after intraocular surgery. A 10-year-old boy presented to the outpatient clinic with retinal detachment in the left eye after 6 years following early-onset cataract surgery. Bilateral panuveitis occurred 3 weeks after surgical repair and resulted in a total visual loss in the left eye and was persistent to conventional treatment in the right eye. Genetic testing revealed a mutation in NOD2 gene. The addition of adalimumab to the treatment regimen resulted in long-term uveitis control and maintenance of 20/70 vision in the right eye. We propose that NOD2-mediated inflammatory cascade can be activated by intraocular surgery and results in the manifestation of BS.</p>}}, author = {{Magliyah, Moustafa and Khan, Abdullah and Alshamrani, Mohammed and Schatz, Patrik and Dhibi, Hassan}}, issn = {{0974-9233}}, keywords = {{Blau syndrome; intraocular surgery; NOD2; panuveitis}}, language = {{eng}}, number = {{3}}, pages = {{196--198}}, publisher = {{Wolters Kluwer}}, series = {{Middle East African Journal of Ophthalmology}}, title = {{Manifestation of panuveitis after intraocular surgery in a child with blau syndrome}}, url = {{http://dx.doi.org/10.4103/meajo.meajo_15_21}}, doi = {{10.4103/meajo.meajo_15_21}}, volume = {{28}}, year = {{2021}}, }